INT51895

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.43
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
neurons 1
thymocyte 1
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 11 100.00 Very High Very High Very High
Limbic system 1 93.04 High High
cerebral cortex 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 34 100.00 Very High Very High Very High
Cancer 168 99.16 Very High Very High Very High
Ovarian Cancer 12 97.40 Very High Very High Very High
Jacobsen Distal 11q Deletion Syndrome 1 91.80 High High
Nasopharynx Cancer 69 89.52 High High
Pyloric Stenosis 3 88.00 High High
Cryptorchidism 3 87.20 High High
Platelet Disorder 2 86.40 High High
Apoptosis 4 85.04 High High
Congenital Anomalies 22 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).
Localization (localization) of OBCAM associated with opioid and adhesions
1) Confidence 0.68 Published 1995 Journal Gene Section Title Doc Link 7721093 Disease Relevance 0.36 Pain Relevance 0.20
Frequent methylation of OPCML in multiple primary tumors
Localization (methylation) of OPCML associated with cancer
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.97 Pain Relevance 0
We thus performed multiplex differential genomic DNA PCR to detect OPCML deletion for a region spanning the frequently deleted marker D11S4085 in epithelial ovarian cancer.
Localization (deletion) of OPCML associated with ovarian cancer
3) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
Homozygous deletion of OPCML was examined using multiplex genomic DNA PCR as previously described [7].
Localization (deletion) of OPCML
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.23 Pain Relevance 0
SNX19 (sorting nexin-19), THYN1 (thymocyte nuclear protein 1), OPCML (opioid-binding protein/cell adhesion molecule-like), VPS26B (vacuolar protein sorting 26, yeast, homolog of B), NCAPD3 (non-SMC condensing II complex subunit D3) and NTM (neurotrimin) might be candidate genes, and the encoded proteins are associated with intracellular trafficking, phosphoinositide binding, mitotic chromosome assembly and segregation, outgrowth of neurites, and apoptosis.

8p23.3 deletion

Localization (opioid) of OPCML in thymocyte associated with apoptosis, opioid and adhesions
5) Confidence 0.45 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.87 Pain Relevance 0.10
Dendrite-associated opioid-binding cell adhesion molecule localizes at neurosecretory granules in the hypothalamic magnocellular neurons.
Localization (localizes) of opioid-binding cell adhesion molecule in neurons associated with opioid and adhesions
6) Confidence 0.04 Published 2003 Journal Neuroscience Section Title Doc Link 14596858 Disease Relevance 0.36 Pain Relevance 0.24

General Comments

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