INT51896

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.80
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
vasculature 2
leukocytes 2
neuronal 1
platelets 1
vascular endothelium 1
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 12 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
cytokine 26 99.84 Very High Very High Very High
chemokine 47 99.32 Very High Very High Very High
Inflammation 115 98.60 Very High Very High Very High
Inflammatory response 28 97.74 Very High Very High Very High
abdominal pain 1 92.44 High High
endometriosis 5 86.56 High High
Multiple sclerosis 82 85.56 High High
Potency 2 79.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 237 100.00 Very High Very High Very High
Nicotine Addiction 369 99.92 Very High Very High Very High
INFLAMMATION 147 98.60 Very High Very High Very High
Endometriosis 10 98.56 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 44 97.18 Very High Very High Very High
Diarrhoea 1 93.80 High High
Fever 13 92.72 High High
Abdominal Pain 1 92.44 High High
Emphysema 2 88.80 High High
Infection 26 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).
Localization (localization) of adhesion molecule associated with opioid and adhesions
1) Confidence 0.47 Published 1995 Journal Gene Section Title Doc Link 7721093 Disease Relevance 0.36 Pain Relevance 0.20
As much of the pulmonary tissue destruction in COPD is thought to be due to the recruitment and activation of inflammatory cells, several researchers have examined the influence of smoking on adhesion molecule expression and release by the endothelial cells comprising the pulmonary vasculature, and recruited alveolar inflammatory cells.
Localization (release) of adhesion molecule in vasculature associated with nicotine addiction, inflammation, chronic obstructive pulmonary disease and adhesions
2) Confidence 0.46 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.99 Pain Relevance 0.16
As much of the pulmonary tissue destruction in COPD is thought to be due to the recruitment and activation of inflammatory cells, several researchers have examined the influence of smoking on adhesion molecule expression and release by the endothelial cells comprising the pulmonary vasculature, and recruited alveolar inflammatory cells.
Localization (release) of adhesion molecule in vasculature associated with nicotine addiction, inflammation, chronic obstructive pulmonary disease and adhesions
3) Confidence 0.46 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.99 Pain Relevance 0.16
Our findings, together with evidence reviewed in prior sections, suggest a broader hypothesis, namely, that platelet interaction with leukocytes at the endothelium of the BBB is responsible for the release of PECAM-1 to the circulation, and associated infiltration of leukocytes.
Localization (release) of PECAM-1 in leukocytes
4) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.60 Pain Relevance 0.20
CPB is associated with major qualitative and quantitative alterations of humoral pathways and changes in leukocyte subsets, generating a systemic inflammatory response [2,4,7,31] with interactions between vascular endothelium, platelets and leukocytes including signal exchanges, adhesion molecule expression and secretion of cytokines or chemokines in a multi-step process.
Localization (secretion) of adhesion molecule in leukocytes associated with chemokine, inflammatory response, adhesions and cytokine
5) Confidence 0.12 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.79 Pain Relevance 0.21
CPB is associated with major qualitative and quantitative alterations of humoral pathways and changes in leukocyte subsets, generating a systemic inflammatory response [2,4,7,31] with interactions between vascular endothelium, platelets and leukocytes including signal exchanges, adhesion molecule expression and secretion of cytokines or chemokines in a multi-step process.
Localization (secretion) of adhesion molecule in vascular endothelium associated with chemokine, inflammatory response, adhesions and cytokine
6) Confidence 0.04 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.79 Pain Relevance 0.21
CPB is associated with major qualitative and quantitative alterations of humoral pathways and changes in leukocyte subsets, generating a systemic inflammatory response [2,4,7,31] with interactions between vascular endothelium, platelets and leukocytes including signal exchanges, adhesion molecule expression and secretion of cytokines or chemokines in a multi-step process.
Localization (secretion) of adhesion molecule in platelets associated with chemokine, inflammatory response, adhesions and cytokine
7) Confidence 0.04 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.79 Pain Relevance 0.21
The chicken GPCR dataset was divided into Adhesion, Frizzled, Glutamate, Secretin, Rhodopsin, and Taste 2 families based on the human dataset.
Localization (based) of Adhesion associated with glutamate and adhesions
8) Confidence 0.01 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.10 Pain Relevance 0.05
Pathogenicity has been attributed to several key virulence factors, including the plasmid-borne Yersinia outer proteins that are delivered by a type III secretion system, the invasion adhesion molecule (Inv), and the high pathogenicity island (HPI) [1].
Localization (secretion) of adhesion molecule associated with adhesions
9) Confidence 0.01 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1959361 Disease Relevance 1.15 Pain Relevance 0.09
These results indicate that OBCAM is a synaptic cell adhesion molecule concerning synaptogenesis and its surface localization is dynamically regulated in response to neuronal activity.
Localization (localization) of adhesion molecule in neuronal associated with adhesions
10) Confidence 0.01 Published 2007 Journal Brain Res. Section Abstract Doc Link 17658490 Disease Relevance 0.23 Pain Relevance 0.05
CONCLUSION(s): No difference in cell adhesion molecule localization nor receptors was observed between endometriotic and endometrial samples, except for fibronectin receptors.
Localization (localization) of adhesion molecule associated with endometriosis and adhesions
11) Confidence 0.01 Published 1997 Journal Fertil. Steril. Section Abstract Doc Link 9022601 Disease Relevance 1.02 Pain Relevance 0.24

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