INT51897

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.59
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
brain 1
T29H 1
neurites 1
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 13 100.00 Very High Very High Very High
metalloproteinase 6 92.84 High High
chemokine 1 76.04 Quite High
agonist 1 67.68 Quite High
antagonist 2 26.84 Quite Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 177 100.00 Very High Very High Very High
Adhesions 33 100.00 Very High Very High Very High
Prostate Cancer 10 99.92 Very High Very High Very High
Nasopharynx Cancer 46 96.04 Very High Very High Very High
Lymphatic System Cancer 32 95.44 Very High Very High Very High
Carcinoma 26 94.88 High High
Apoptosis 41 94.76 High High
Jacobsen Distal 11q Deletion Syndrome 1 91.80 High High
Pyloric Stenosis 3 88.00 High High
Cryptorchidism 3 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous work has shown that limbic-system-associated protein (LAMP), CEPU-1/Neurotrimin and OBCAM interact homophilically and heterophilically within the family.
OBCAM Binding (interact) of
1) Confidence 0.43 Published 2004 Journal J. Cell. Sci. Section Abstract Doc Link 15265982 Disease Relevance 0.44 Pain Relevance 0.09
Through these domains, OPCML may bind directly to growth promoting or inhibitory molecules and modulate their functions in tumor cells.
OPCML Binding (bind) of associated with cancer
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.93 Pain Relevance 0
OPCML probably functions as a tumor suppressor through interacting with other IgLONs to form heterodimeric complex [30] involved in signal transduction.
OPCML Binding (interacting) of associated with cancer
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.08 Pain Relevance 0
Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).
OBCAM Binding (binding) of associated with opioid and adhesions
4) Confidence 0.34 Published 1995 Journal Gene Section Title Doc Link 7721093 Disease Relevance 0.36 Pain Relevance 0.20
One member of the family, opioid-binding cell-adhesion molecule (OBCAM), might act as a tumour suppressor.
OBCAM Spec (might) Binding (binding) of associated with cancer, opioid and adhesions
5) Confidence 0.32 Published 2004 Journal J. Cell. Sci. Section Abstract Doc Link 15265982 Disease Relevance 0.44 Pain Relevance 0.10
Furthermore, suppression of oncogenic RAS activity by stable siRNA specific for HRAS(V12) led to the demethylation and re-expression of OPCML in T29H cells, demonstrating that oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML.
OPCML Binding (silencing) of in T29H
6) Confidence 0.32 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.30 Pain Relevance 0.05
Oligodeoxyribonucleotide (oligo) primers derived from rat opioid-binding cell adhesion molecule (OBCAM)-encoding cDNA sequence were used to amplify a 403-bp fragment from a human brain cDNA library using the polymerase chain reaction (PCR).
OBCAM Binding (binding) of in brain associated with opioid and adhesions
7) Confidence 0.30 Published 1995 Journal Gene Section Abstract Doc Link 7721093 Disease Relevance 0.32 Pain Relevance 0.17
OBCAM Opioid binding cell adhesion molecule
OBCAM Binding (binding) of associated with opioid and adhesions
8) Confidence 0.24 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.78 Pain Relevance 0.40
SNX19 (sorting nexin-19), THYN1 (thymocyte nuclear protein 1), OPCML (opioid-binding protein/cell adhesion molecule-like), VPS26B (vacuolar protein sorting 26, yeast, homolog of B), NCAPD3 (non-SMC condensing II complex subunit D3) and NTM (neurotrimin) might be candidate genes, and the encoded proteins are associated with intracellular trafficking, phosphoinositide binding, mitotic chromosome assembly and segregation, outgrowth of neurites, and apoptosis.

8p23.3 deletion

OPCML Binding (associated) of in neurites associated with apoptosis, opioid and adhesions
9) Confidence 0.22 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.95 Pain Relevance 0.10

General Comments

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