INT51898

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 18.87
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
leukocyte 5
neutrophil 2
brain 1
platelet 1
mesenchymal condensation 1
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 42 100.00 Very High Very High Very High
Opioid 7 99.98 Very High Very High Very High
Inflammation 279 99.68 Very High Very High Very High
sodium channel 3 98.40 Very High Very High Very High
rheumatoid arthritis 122 98.20 Very High Very High Very High
substance P 7 97.52 Very High Very High Very High
Snapping jaw 5 97.44 Very High Very High Very High
Calcitonin gene-related peptide 8 96.84 Very High Very High Very High
Neuropathic pain 5 95.60 Very High Very High Very High
backache 2 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 694 100.00 Very High Very High Very High
Nicotine Addiction 1106 99.92 Very High Very High Very High
INFLAMMATION 332 99.68 Very High Very High Very High
Anaphylaxis 28 99.12 Very High Very High Very High
Cancer 142 99.00 Very High Very High Very High
Hemangioma 3 98.32 Very High Very High Very High
Rheumatoid Arthritis 122 98.20 Very High Very High Very High
Metastasis 28 97.84 Very High Very High Very High
Temporomandibular Joint Syndrome 5 97.44 Very High Very High Very High
Low Back Pain 2 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After local excision, the pathologic diagnosis was atypical epithelioid hemangioma (central epithelioid cells bordered by immature vessels), with immunohistochemical positivity for CD31 and CD34 and negativity for epithelial membrane antigen.
CD31 Binding (positivity) of in vessels associated with hemangioma
1) Confidence 0.36 Published 2009 Journal Urology Section Abstract Doc Link 18342919 Disease Relevance 0.42 Pain Relevance 0.08
Blood vessels were identified by immunoreactivity with platelet-endothelial cell-adhesion molecule (CD31; PECAM).
PECAM Binding (immunoreactivity) of in Blood vessels associated with adhesions
2) Confidence 0.36 Published 1997 Journal J Bone Joint Surg Br Section Abstract Doc Link 9020464 Disease Relevance 0.44 Pain Relevance 0.68
Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).
adhesion molecule Binding (binding) of associated with opioid and adhesions
3) Confidence 0.24 Published 1995 Journal Gene Section Title Doc Link 7721093 Disease Relevance 0.36 Pain Relevance 0.20
Oligodeoxyribonucleotide (oligo) primers derived from rat opioid-binding cell adhesion molecule (OBCAM)-encoding cDNA sequence were used to amplify a 403-bp fragment from a human brain cDNA library using the polymerase chain reaction (PCR).
adhesion molecule Binding (binding) of in brain associated with opioid and adhesions
4) Confidence 0.24 Published 1995 Journal Gene Section Abstract Doc Link 7721093 Disease Relevance 0.32 Pain Relevance 0.17
B, a transcription factor, binds to a consensus site in specific adhesion molecule genes.
adhesion molecule Binding (binds) of associated with adhesions
5) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.93 Pain Relevance 0.12
The influence of tobacco smoking on adhesion molecule profiles

Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci.

adhesion molecule Binding (interactions) of in leukocyte associated with nicotine addiction, inflammation and adhesions
6) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Title Doc Link PMC2669563 Disease Relevance 1.60 Pain Relevance 0.16
However, homophilic interactions of specific adhesion molecules [junctional adhesion molecules (JAM), platelet-endothelial cell adhesion molecule-1 (PECAM-1; CD31), and vascular endothelial cadherin (VE-cadherin; CDH5)] may play important roles in maintaining endothelial-endothelial cell adhesion, and these adhesion molecule interactions are probably disrupted in order to permit leukocyte transmigration [31-34].
adhesion molecule Binding (interactions) of in leukocyte associated with adhesions
7) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.29 Pain Relevance 0.08
B, a transcription factor, binds to a consensus site in specific adhesion molecule genes.
adhesion molecule Binding (binds) of associated with adhesions
8) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.93 Pain Relevance 0.12
The influence of tobacco smoking on adhesion molecule profiles

Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci.

adhesion molecule Binding (interactions) of in leukocyte associated with nicotine addiction, inflammation and adhesions
9) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Title Doc Link PMC2671531 Disease Relevance 1.60 Pain Relevance 0.16
However, homophilic interactions of specific adhesion molecules [junctional adhesion molecules (JAM), platelet-endothelial cell adhesion molecule-1 (PECAM-1; CD31), and vascular endothelial cadherin (VE-cadherin; CDH5)] may play important roles in maintaining endothelial-endothelial cell adhesion, and these adhesion molecule interactions are probably disrupted in order to permit leukocyte transmigration [31-34].
adhesion molecule Binding (interactions) of in leukocyte associated with adhesions
10) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.29 Pain Relevance 0.08
CD146 is a cell adhesion molecule that belongs to the immunoglobulin supergene family and is potentially involved in leukocyte–endothelial interactions [34].
adhesion molecule Binding (interactions) of in leukocyte associated with adhesions
11) Confidence 0.20 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.28 Pain Relevance 0.34
Regulation of neutrophil migration into inflammatory sites reflects interactions between the IL-8 chemokine and the ICAM-1 adhesion molecule.
adhesion molecule Binding (interactions) of in neutrophil associated with chemokine, inflammation and adhesions
12) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.49 Pain Relevance 0.24
For example, markers previously used to prove endothelial identity of putative progenitors, such as CD31, lectin binding or LDL accumulation are now known to be non-specific for the endothelial lineage, but also characteristic for cells of haematopoietic origin] [111,112].
CD31 Binding (binding) of
13) Confidence 0.18 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0 Pain Relevance 0
A number of markers expressed by the MDA-MB-231 cells, including thrombin receptor, TIE-2, CD31, VEGF, and bc-48, have been shown to be associated with endothelial cells [30-34].
CD31 Binding (associated) of in endothelial cells
14) Confidence 0.16 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.72 Pain Relevance 0
(no. 8) SHP-1 is a splice variant of SHP-2, which binds with lesser affinity to PECAM-1 during platelet aggregation [70].
PECAM-1 Binding (affinity) of in platelet
15) Confidence 0.16 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.13 Pain Relevance 0.10
The analysis revealed that the Ciona Adhesion family clustered into five different groups each receiving more than 75 % bootstrap support in (1000 bootstraps) NJ trees (Figure 5).
Adhesion Binding (receiving) of associated with adhesions
16) Confidence 0.06 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 1.00 Pain Relevance 0
One member of the family, opioid-binding cell-adhesion molecule (OBCAM), might act as a tumour suppressor.
adhesion molecule Binding (binding) of associated with cancer, opioid and adhesions
17) Confidence 0.06 Published 2004 Journal J. Cell. Sci. Section Abstract Doc Link 15265982 Disease Relevance 0.44 Pain Relevance 0.10
This adhesion molecule on the cell surface of phagocytic leukocytes may bind to counter-receptors, such as intercellular adhesion molecule-1 (ICAM-1), present on the surface of vascular endothelium.
adhesion molecule Binding (bind) of in vascular endothelium associated with adhesions
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.80 Pain Relevance 0.08
Of note, ERT increased the generation of ROS in vitro, and up-regulated the intracellular adhesion molecule ICAM 1.
adhesion molecule Binding (intracellular) of associated with adhesions
19) Confidence 0.03 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2768700 Disease Relevance 0.88 Pain Relevance 0.03
These data indicate that LAMP is a highly conserved new member of the IgSF which, together with the opioid-binding cell adhesion molecule (OBCAM) and neurotrimin, comprises a new subfamily that has been designated as IgLONs.
adhesion molecule Binding (binding) of associated with opioid and adhesions
20) Confidence 0.03 Published 1996 Journal Gene Section Abstract Doc Link 8666243 Disease Relevance 0.10 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox