INT519

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 52
Total Number 65
Disease Relevance 17.65
Pain Relevance 20.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
brain 6
plasma 2
arm 2
liver 1
erythrocytes 1
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 2025 100.00 Very High Very High Very High
Catecholamine 118 100.00 Very High Very High Very High
Potency 39 99.98 Very High Very High Very High
medulla 1 99.88 Very High Very High Very High
Dopamine 827 99.50 Very High Very High Very High
lidocaine 9 99.48 Very High Very High Very High
diabetic neuropathy 1 99.18 Very High Very High Very High
Dorsal horn 1 98.98 Very High Very High Very High
opiate 2 98.82 Very High Very High Very High
agonist 145 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diarrhoea 104 99.80 Very High Very High Very High
Hepatotoxicity 79 99.64 Very High Very High Very High
Sprains And Strains 2 99.60 Very High Very High Very High
Diabetic Neuropathy 1 99.18 Very High Very High Very High
Vomiting 56 98.34 Very High Very High Very High
Disease 1813 98.32 Very High Very High Very High
Celiac Disease 43 98.00 Very High Very High Very High
Heartburn 32 97.20 Very High Very High Very High
Pain 104 97.06 Very High Very High Very High
Abdominal Pain 38 96.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, electrophysiological field potential recordings from the dorsal horn in rats were used to examine the spinal effect of reduced COMT activity.
Spec (examine) Negative_regulation (reduced) of COMT in spinal associated with catechol-o-methyltransferase and dorsal horn
1) Confidence 0.59 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20219633 Disease Relevance 0.26 Pain Relevance 0.69
Inhibition of COMT activity by lidocaine may contribute to this effect.
Negative_regulation (Inhibition) of COMT associated with lidocaine
2) Confidence 0.59 Published 1995 Journal Schweiz Monatsschr Zahnmed Section Abstract Doc Link 7716464 Disease Relevance 0.07 Pain Relevance 0.95
But
               COMT inhibition may also promote the synthesis of more basic LD metabolites, ie, the
               tyrosine aminotransferase-dependent substrates dihydroxyphenylpyruvate acetate and
               trihydroxyphenylacetate. 
Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
3) Confidence 0.59 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.13 Pain Relevance 0.23
These findings warrant a discussion about which COMT inhibitor, EN or tolcapone, is
               more suitable for modulating homocysteine synthesis. 
Negative_regulation (inhibitor) of COMT associated with catechol-o-methyltransferase
4) Confidence 0.59 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.05 Pain Relevance 0.26
Therapy of homocysteine elevation with COMT inhibition
Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
5) Confidence 0.59 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.53 Pain Relevance 0.23
A tendency was also observed in the brain toward a decrease in the activity of DBH and COMT and an increase in the activity of cAMP and cGMP.
Negative_regulation (decrease) of COMT in brain
6) Confidence 0.51 Published 1994 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 7969881 Disease Relevance 0.28 Pain Relevance 0.22
There is accumulating evidence that continuous nigrostriatal
               postsynaptic dopaminergic receptor stimulation may prevent onset of motor
                   complications.14

COMT inhibition and onset of motor complications

Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
7) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.11 Pain Relevance 0.32
This was blocked by COMT inhibition, which was seen as neuroprotective.
Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
8) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0 Pain Relevance 0.37
Thus exclusive
               central COMT inhibition may also force central dopamine degradation to metabolism
               via monoaminooxidase B, which generates oxidative stress. 
Negative_regulation (inhibition) of COMT associated with stress, catechol-o-methyltransferase and dopamine
9) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.18 Pain Relevance 0.38
But COMT inhibition with
               EN increased the recovery rate of the salt [13C]-sodium-octanoate.25,29,30

The anti-acid scenario of COMT inhibition

Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
10) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0 Pain Relevance 0.13
COMT inhibition and 3-OMD metabolism
Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
11) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.09 Pain Relevance 0.19
LD/DDI and COMT inhibition
Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
12) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.22 Pain Relevance 0.28
COMT inhibition and muscle function
Negative_regulation (inhibition) of COMT in muscle associated with catechol-o-methyltransferase
13) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.47 Pain Relevance 0.18
Therefore COMT inhibition may model the environmental pH
               and the physicochemical properties of LD for its duodenal absorption. 
Negative_regulation (inhibition) of COMT associated with catechol-o-methyltransferase
14) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.06 Pain Relevance 0.18
One must realize that 300 mg LD/CD are not comparable to 300 mg LD/CD/EN,
               since the additional COMT inhibition with EN delivers more LD to the brain and thus
               improves the clinical efficacy of LD.
Negative_regulation (inhibition) of COMT in brain associated with catechol-o-methyltransferase
15) Confidence 0.51 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.45 Pain Relevance 0.18
This small prospective trial provided some
               evidence that COMT inhibition lowers homocysteine generation.51 In rats, this was also shown with the peripherally
               acting COMT inhibitor EN.52
               Clinical data of EN in humans are still under discussion. 
Negative_regulation (inhibitor) of COMT associated with catechol-o-methyltransferase
16) Confidence 0.43 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.22 Pain Relevance 0.28
Addition of TTX to Ringer, although abolishing DA output in the absence of L-DOPA, partially reduced it in the presence of L-DOPA+Ro 40-7592 and even more so after L-DOPA without the COMT inhibitor.
Negative_regulation (reduced) of COMT associated with catechol-o-methyltransferase, tetrodotoxin and dopamine
17) Confidence 0.42 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1613509 Disease Relevance 0 Pain Relevance 0.86
Studies have shown that concomitant use of a COMT inhibitor is highly beneficial in controlling the wearing-off phenomenon by improving L-DOPA bioavailability as well as brain entry.
Negative_regulation (inhibitor) of COMT in brain associated with bioavailability
18) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2916818 Disease Relevance 0.10 Pain Relevance 0.05
Tolcapone is a potent, reversible catechol-O-methyltransferase (COMT) inhibitor with both peripheral and central activity.
Negative_regulation (inhibitor) of catechol-O-methyltransferase associated with catechol-o-methyltransferase
19) Confidence 0.38 Published 1998 Journal Mov. Disord. Section Abstract Doc Link 9686768 Disease Relevance 0.25 Pain Relevance 0.25
Tolcapone is a potent, reversible catechol-O-methyltransferase (COMT) inhibitor with both peripheral and central activity.
Negative_regulation (inhibitor) of COMT associated with catechol-o-methyltransferase
20) Confidence 0.38 Published 1998 Journal Mov. Disord. Section Abstract Doc Link 9686768 Disease Relevance 0.25 Pain Relevance 0.25

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