INT51906

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.96 Very High Very High Very High
gABA 6 99.08 Very High Very High Very High
Potency 1 95.32 Very High Very High Very High
headache 2 93.60 High High
abdominal pain 1 89.36 High High
Nerve growth factor 1 89.08 High High
Serotonin 1 87.76 High High
Central nervous system 1 72.48 Quite High
Neurotransmitter 1 67.60 Quite High
Analgesic 1 59.12 Quite High
Disease Link Frequency Relevance Heat
Fatigue 2 98.76 Very High Very High Very High
Hypoglycemia 1 96.84 Very High Very High Very High
Bartter Syndrome 1 96.28 Very High Very High Very High
Congenital Anomalies 1 94.92 High High
Headache 2 93.60 High High
Tremor 1 93.08 High High
Motor Neuron Diseases 2 90.00 High High
Generalized Anxiety Disorder 2 89.84 High High
Abdominal Pain 1 89.36 High High
Vomiting 1 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased expression of beta 2-adrenergic receptors may limit the expected functional improvement.
Negative_regulation (Decreased) of Gene_expression (expression) of beta 2
1) Confidence 0.57 Published 1999 Journal Nervenarzt Section Abstract Doc Link 10637819 Disease Relevance 0.74 Pain Relevance 0.14
Following 4- or 21-day periods of monocular deprivation induced by intravitreal injections of tetrodotoxin, levels of the alpha 1, alpha 2, alpha 4, alpha 5, beta 1, and beta 2 mRNAs were decreased in the deprived geniculate laminae.
Negative_regulation (decreased) of Gene_expression (levels) of beta 2 associated with tetrodotoxin
2) Confidence 0.41 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721992 Disease Relevance 0.16 Pain Relevance 0.10
Sustained decreases in beta 2-microglobulin, neopterin, and p24 antigen levels were seen over the 52-week study.
Negative_regulation (decreases) of Gene_expression (levels) of beta 2
3) Confidence 0.41 Published 1995 Journal J. Infect. Dis. Section Abstract Doc Link 7751691 Disease Relevance 0.60 Pain Relevance 0.18
It also inhibited the function of human nicotinic acetylcholine receptors composed of the alpha4 and beta2 subunits, but this effect was only partial and apparent at high concentrations.
Negative_regulation (inhibited) of Gene_expression (composed) of beta2
4) Confidence 0.41 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17234181 Disease Relevance 0.06 Pain Relevance 0.49

General Comments

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