INT51912

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.42
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
brainstem 2
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 3 100.00 Very High Very High Very High
Lasting pain 2 99.98 Very High Very High Very High
Pain 1 99.74 Very High Very High Very High
Dopamine 212 99.28 Very High Very High Very High
Enkephalin 10 97.04 Very High Very High Very High
Central nervous system 1 93.96 High High
Antinociceptive 2 90.84 High High
midbrain 5 88.96 High High
Central grey 13 88.60 High High
Neuropeptide 11 82.04 Quite High
Disease Link Frequency Relevance Heat
Pain 2 99.98 Very High Very High Very High
Stress 4 99.80 Very High Very High Very High
Nociception 10 96.04 Very High Very High Very High
Urological Neuroanatomy 13 88.60 High High
Pressure Volume 2 Under Development 1 79.72 Quite High
Arthritis 1 69.92 Quite High
INFLAMMATION 1 68.04 Quite High
Diabetic Nephropathy 1 66.44 Quite High
Volume Depletion And Dehydration 1 25.68 Quite Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, there are concomitant increases in cellular levels of both neurotensin/neuromedin N and proenkephalin mRNAs.
Positive_regulation (increases) of Transcription (levels) of neurotensin/neuromedin N
1) Confidence 0.45 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721997 Disease Relevance 0.08 Pain Relevance 0.04
A clear upregulation of neurotensin mRNA was seen after ether and, to a lesser extent, after immobilization stress, whereas after the two other stressors neurotensin mRNA was undetectable, as in control rats.
Positive_regulation (after) of Transcription (undetectable) of neurotensin associated with stress
2) Confidence 0.45 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8337918 Disease Relevance 0.29 Pain Relevance 0.25
Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception.
Positive_regulation (increases) of Transcription (expression) of neuromedin-N in brainstem associated with nociception, medulla and lasting pain
3) Confidence 0.45 Published 1993 Journal Brain Res. Section Title Doc Link 8518953 Disease Relevance 1.05 Pain Relevance 0.89
Striatal DA depletion also induced significant increases (2.86-fold) in Nts mRNA levels (Figure 3D).
Positive_regulation (increases) of Transcription (levels) of Nts associated with dopamine
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.20
The METH injection caused increases (2.21-fold) in Nts mRNA in the control animals (MC group), confirming previous results, which showed that METH induced a dramatic increase in striatal Nts mRNA levels [41].
Positive_regulation (increase) of Transcription (levels) of Nts
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.11

General Comments

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