INT51921

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Context Info
Confidence 0.73
First Reported 1994
Last Reported 2010
Negated 15
Speculated 11
Reported most in Abstract
Documents 501
Total Number 513
Disease Relevance 229.81
Pain Relevance 157.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
kidney 13
spinal cord 12
microglia 12
spinal 9
brain 9
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2052 100.00 Very High Very High Very High
cINOD 1709 100.00 Very High Very High Very High
cytokine 878 100.00 Very High Very High Very High
COX2 443 100.00 Very High Very High Very High
COX-2 inhibitor 405 100.00 Very High Very High Very High
cOX1 292 100.00 Very High Very High Very High
Spinal cord 112 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
Inflammatory stimuli 78 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2983 100.00 Very High Very High Very High
Cancer 807 100.00 Very High Very High Very High
Functional Bowel Disorder 16 100.00 Very High Very High Very High
Hyperplasia 10 100.00 Very High Very High Very High
Adhesions 7 100.00 Very High Very High Very High
Transitional Cell Carcinoma 5 100.00 Very High Very High Very High
Peptic Ulcer 54 99.96 Very High Very High Very High
Toxicity 269 99.92 Very High Very High Very High
Neuroblastoma 43 99.84 Very High Very High Very High
Volume Depletion And Dehydration 12 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas paracetamol inhibited only COX enzyme activity, caffeine also inhibited COX-2 protein synthesis.
Gene_expression (synthesis) of COX associated with paracetamol
1) Confidence 0.73 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10963764 Disease Relevance 0 Pain Relevance 1.06
In this study, we characterized COX-mediated arachidonic acid metabolism in NMBA-induced rat esophageal tumorigenesis by measuring COX-1 and COX-2 expression and prostaglandin E(2) production.
Gene_expression (expression) of COX
2) Confidence 0.72 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.33 Pain Relevance 0.07
In this study, we characterized COX-mediated arachidonic acid metabolism in NMBA-induced rat esophageal tumorigenesis by measuring COX-1 and COX-2 expression and prostaglandin E(2) production.
Gene_expression (expression) of COX
3) Confidence 0.72 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.32 Pain Relevance 0.07
Twenty-five weeks after the initiation of NMBA treatment, we observed an elevation in COX mRNA and protein expression and prostaglandin E(2) production in NMBA-treated esophageal tissues compared with normal epithelium.
Gene_expression (expression) of COX mRNA in epithelium
4) Confidence 0.72 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.30 Pain Relevance 0.05
Pharmacological characterization of this behavior has implicated the spinal release of excitatory amino acids (EAAs) and cyclooxygenase (COX) products.
Gene_expression (products) of COX in spinal associated with excitatory amino acid
5) Confidence 0.66 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7722627 Disease Relevance 0 Pain Relevance 0.21
All-trans retinoic acid (ATRA), the active metabolite of vitamin A, is involved in the inflammatory reaction and modulates the expression of cyclooxygenase (COX) enzymes and nitric oxide (NO) activity.
Gene_expression (expression) of COX associated with inflammation
6) Confidence 0.64 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16870215 Disease Relevance 0.18 Pain Relevance 0.59
TMCs, unlike other mast cells, do not express cyclooxygenase (COX) - the key enzyme in the production of prostanoids and the main site of action of ASA - thus dismissing a direct local cellular COX-mediated action.
Neg (not) Gene_expression (express) of COX in mast cells associated with aspirin
7) Confidence 0.56 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 16169091 Disease Relevance 0.17 Pain Relevance 1.31
Twenty-five weeks after the initiation of NMBA treatment, we observed an elevation in COX mRNA and protein expression and prostaglandin E(2) production in NMBA-treated esophageal tissues compared with normal epithelium.
Gene_expression (production) of COX mRNA in epithelium
8) Confidence 0.56 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.31 Pain Relevance 0.05
We adjusted all Cox models for variables that (based on the existing literature) could be potential confounders: first degree family history of cancer (yes or no), school education (?
Gene_expression (models) of Cox associated with cancer
9) Confidence 0.55 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2965150 Disease Relevance 0.56 Pain Relevance 0.08
Main outcome measure Risk of colorectal cancer in relation to points achieved in the lifestyle index (based on physical activity, waist circumference, smoking, alcohol intake, and diet (dietary fibre, energy percentage from fat, red and processed meat, and fruits and vegetables)) modelled through Cox regression.
Gene_expression (regression) of Cox in fat associated with nicotine addiction, colon cancer and alcohol
10) Confidence 0.55 Published 2010 Journal BMJ : British Medical Journal Section Abstract Doc Link PMC2965150 Disease Relevance 0.74 Pain Relevance 0.05
Data were analysed using Cox regression and multivariate analyses.
Spec (analyses) Gene_expression (regression) of Cox
11) Confidence 0.55 Published 2009 Journal Emerg Med Australas Section Body Doc Link 19254313 Disease Relevance 0 Pain Relevance 0
Evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cycloxygenase (COX) and production of the proinflammatory prostaglandin, PGE2, and thus prevent carcinogenesis in the colon.
Gene_expression (production) of COX in colon associated with inflammation and cinod
12) Confidence 0.55 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 20225762 Disease Relevance 0.40 Pain Relevance 0.24
The expression of COX-2 mRNA and immuno-positive cells was observed in the gastric mucosa of arthritic but not normal rats.
Gene_expression (expression) of COX associated with arthritis
13) Confidence 0.51 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388629 Disease Relevance 0.86 Pain Relevance 0.31
In contrast with other COX gene defects that produce the classical hepatic porphyria presentation, our data suggest that the K404E substitution (either in the homozygous or compound heterozygous state associated with a mutation leading to the absence of functional mRNA or protein) is responsible for the specific hematologic clinical manifestations of harderoporphyria.
Gene_expression (produce) of COX gene associated with hepatic porphyrias
14) Confidence 0.49 Published 1998 Journal Blood Section Abstract Doc Link 9454777 Disease Relevance 0.83 Pain Relevance 0.13
In neuroblastoma it has been shown that the majority of primary tumours and cell lines express high levels of COX-2, whereas normal adrenal medullas from children do not express COX-2.
Neg (not) Gene_expression (express) of COX in adrenal medullas associated with neuroblastoma and cancer
15) Confidence 0.49 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15975708 Disease Relevance 0.98 Pain Relevance 0.38
In neuroblastoma it has been shown that the majority of primary tumours and cell lines express high levels of COX-2, whereas normal adrenal medullas from children do not express COX-2.
Gene_expression (express) of COX in adrenal medullas associated with neuroblastoma and cancer
16) Confidence 0.49 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15975708 Disease Relevance 0.90 Pain Relevance 0.36
BACKGROUND & AIMS: The critical role of cyclooxygenase (COX) products in maintenance of renal function in cirrhosis with ascites discourages the use of nonsteroidal anti-inflammatory drugs in this disease.
Gene_expression (products) of COX associated with pressure and volume under development, inflammation, cirrhosis, cinod and disease
17) Confidence 0.49 Published 1999 Journal Gastroenterology Section Abstract Doc Link 10220509 Disease Relevance 0.62 Pain Relevance 0.22
Sodium valproate, a mood stabilizer, when chronically administered to rats (200 mg/kg i.p. daily for 30 days) significantly reduced the brain protein levels of cyclooxygenase (COX)-1 and COX-2, without altering the mRNA levels of these enzymes.
Gene_expression (levels) of COX in brain
18) Confidence 0.49 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694395 Disease Relevance 0 Pain Relevance 0
TMCs, unlike other mast cells, do not express cyclooxygenase (COX) - the key enzyme in the production of prostanoids and the main site of action of ASA - thus dismissing a direct local cellular COX-mediated action.
Gene_expression (production) of COX in mast cells associated with aspirin
19) Confidence 0.49 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 16169091 Disease Relevance 0.17 Pain Relevance 1.31
Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.
Gene_expression (expression) of COX in stomach
20) Confidence 0.49 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15082878 Disease Relevance 0.05 Pain Relevance 0.04

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