INT51922

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 12.05
Pain Relevance 8.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
spinal 3
retina 2
liver 1
colon 1
microglia 1
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 15 100.00 Very High Very High Very High
excitatory amino acid 4 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
cytokine 54 99.98 Very High Very High Very High
Inflammation 104 99.80 Very High Very High Very High
Calcitonin gene-related peptide 3 99.76 Very High Very High Very High
cINOD 42 99.18 Very High Very High Very High
intrathecal 70 98.64 Very High Very High Very High
Acute pain 2 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 145 99.80 Very High Very High Very High
Cancer 31 99.40 Very High Very High Very High
Pain 52 98.56 Very High Very High Very High
Necrosis 9 98.38 Very High Very High Very High
Syndrome 2 98.36 Very High Very High Very High
Collagenous Colitis 1 97.64 Very High Very High Very High
Nociception 18 97.48 Very High Very High Very High
Endometriosis 7 97.44 Very High Very High Very High
Disease 74 96.94 Very High Very High Very High
Fibrosis 1 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological characterization of this behavior has implicated the spinal release of excitatory amino acids (EAAs) and cyclooxygenase (COX) products.
Localization (release) of COX in spinal associated with excitatory amino acid
1) Confidence 0.68 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7722627 Disease Relevance 0 Pain Relevance 0.19
The localization of COX and soluble guanylyl cyclase in rat retina was examined using immunohistochemistry.
Spec (examined) Localization (localization) of COX in retina
2) Confidence 0.49 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19625688 Disease Relevance 0.16 Pain Relevance 0.12
The selective cyclooxygenase-2 (COX) inhibitor, celecoxib, and the non-selective COX-1 and COX-2 inhibitor, indomethacin, at microM concentrations, stimulate the release of arachidonic acid from rat liver cells (the C-9 cell line).
Localization (release) of COX in liver associated with cox-2 inhibitor
3) Confidence 0.46 Published 2001 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 11487305 Disease Relevance 0.09 Pain Relevance 0.42
In addition, we immunolocalized COX-1 and COX-2 in the same tumour and normal colonic tissue.
Localization (immunolocalized) of COX associated with cancer
4) Confidence 0.44 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.07 Pain Relevance 0.42
In addition, we immunolocalized COX-1 and COX-2 in the same tumour and normal colonic tissue.
Localization (immunolocalized) of COX associated with cancer
5) Confidence 0.44 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.07 Pain Relevance 0.42
Two forms of COX have been identified: COX-1, which is constitutively expressed in most tissues and organs, and COX-2, which is an inducible enzyme and is localized primarily in inflammatory cells and tissues.
Localization (localized) of COX associated with inflammation
6) Confidence 0.39 Published 1996 Journal Brain Res. Section Abstract Doc Link 8955930 Disease Relevance 0.35 Pain Relevance 0.17
Two forms of COX have been identified: COX-1, which is constitutively expressed in most tissues and organs, and COX-2, which is an inducible enzyme and is localized primarily in inflammatory cells and tissues.
Localization (localized) of COX associated with inflammation
7) Confidence 0.37 Published 1996 Journal Brain Res. Section Abstract Doc Link 8955930 Disease Relevance 0.35 Pain Relevance 0.17
This suggests that NSAIDs therapeutic profile is related to their selectivity for COX isoforms and COX-2 is involved in the initiation but not in the maintenance of nociceptive spinal activation, which depends on COX-1.
Localization (selectivity) of COX in spinal associated with nociception and cinod
8) Confidence 0.35 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19463915 Disease Relevance 0.67 Pain Relevance 0.64
NO-->-(IL-1beta-->+COX-->+PG-->+OT release).
Localization (release) of COX
9) Confidence 0.23 Published 2002 Journal Brain Res. Section Abstract Doc Link 12020869 Disease Relevance 0 Pain Relevance 0.26
Cox-1 immunolabelling was almost exclusively restricted to small diameter DRG neurons (< 1000 microm2), and was extensively colocalized with calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4).
Localization (colocalized) of Cox in neurons associated with calcitonin gene-related peptide
10) Confidence 0.22 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10762321 Disease Relevance 0.07 Pain Relevance 0.14
Effects of NS-398 on activities of these two distinct forms of COX were investigated.
Localization (forms) of COX
11) Confidence 0.18 Published 1994 Journal Prostaglandins Section Abstract Doc Link 8140262 Disease Relevance 0.23 Pain Relevance 0.26
Celecoxib (at low dose) [57,58] and other NSAIDs (and minocycline) inhibit p38MAPK leading to a decrease in COX-2 production, decreased mRNA stability and decreased PGE2 release.
Localization (decrease) of COX associated with cinod
12) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483059 Disease Relevance 0.82 Pain Relevance 0.70
Results from control experiments using other highly selective COX-1 inhibitors (SC-560 and VAS), in addition to resveratrol, indicate that COX-1 isoform is not only important in LPS-induced PGE2 synthesis, but it is also a key source of free radicals in microglia.
Localization (important) of COX in microglia
13) Confidence 0.14 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.20 Pain Relevance 0.03
Vascular reactivity in the presence of the hydrogen peroxide scavenger catalase (1200 U/mL) or an inhibitor of cyclooxygenase (COX) (indomethacin, 10 ?
Localization (presence) of COX
14) Confidence 0.14 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.35 Pain Relevance 0
Measurement of COX-2 and ICAM-1
Localization (Measurement) of COX
15) Confidence 0.10 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2880261 Disease Relevance 0.38 Pain Relevance 0.14
and the appearance of COX-2 and ICAM were statistically not different in each group.


Localization (appearance) of COX
16) Confidence 0.09 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2880261 Disease Relevance 0.61 Pain Relevance 0.03
peptide-induced inflammatory cytokine release; and iNOS, COX-2 and MnSOD expression.


Localization (release) of COX associated with inflammation and cytokine
17) Confidence 0.08 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.47 Pain Relevance 0.33
The PLA2 targeted by alminoprofen is likely the secretory phospholipase A2 (sPLA2) while the COX targeted is the COX-2.
Localization (secretory) of COX
18) Confidence 0.07 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 9933032 Disease Relevance 0.34 Pain Relevance 0.39
By using immunohistochemistry, we have compared the cellular expression and localization of COX-1 and COX-2 in the normal mouse, rat, and human retina.
Localization (localization) of COX in retina
19) Confidence 0.07 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12355421 Disease Relevance 0.39 Pain Relevance 0.17
We isolated a dibenzylbutyrolactone diterpene acid, 7-oxosandaracopimaric acid (OSA), from the ether fraction of Aralia cordata MeOH extract, and studied the effect of OSA on phenylquinone (PQ)-induced writhing syndrome and PQ-induced capillary permeability increase, compound 48/80-induced histamine release by peritoneal mast cells, cycloxygenase (COX) activities, and silica-induced RAW 264.7 cell reactive oxygen species production.
Localization (release) of COX in mast cells associated with syndrome
20) Confidence 0.06 Published 2010 Journal Arch. Pharm. Res. Section Abstract Doc Link 20422358 Disease Relevance 0.61 Pain Relevance 0.24

General Comments

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