INT5194

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 63
Total Number 63
Disease Relevance 26.44
Pain Relevance 8.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 4
brain 4
plasma 3
pancreas 2
nerves 2
Lpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 7 100.00 Very High Very High Very High
Paracetamol 22 99.98 Very High Very High Very High
Spinal cord 7 99.84 Very High Very High Very High
Enkephalin 3 99.84 Very High Very High Very High
emotional pain 10 99.68 Very High Very High Very High
ischemia 70 99.36 Very High Very High Very High
Pain 36 99.30 Very High Very High Very High
Angina 8 98.68 Very High Very High Very High
anesthesia 40 98.52 Very High Very High Very High
Hippocampus 7 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 260 99.82 Very High Very High Very High
Diabetes Mellitus 270 99.80 Very High Very High Very High
Pain 25 99.68 Very High Very High Very High
Poisoning 118 99.58 Very High Very High Very High
Cv General 4 Under Development 14 99.36 Very High Very High Very High
Disease 18 99.30 Very High Very High Very High
Coronary Heart Disease 1 99.20 Very High Very High Very High
Middle Cerebral Artery Infarction 19 99.16 Very High Very High Very High
Gallstones 7 99.14 Very High Very High Very High
Stable Angina Pectoris 2 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The behavioral disorders in dependent animals were accompanied by LPO activation in liver and brain membranes.
Positive_regulation (activation) of LPO in brain
1) Confidence 0.70 Published 1992 Journal Eksp Klin Farmakol Section Abstract Doc Link 1363943 Disease Relevance 0.17 Pain Relevance 0.66
LPO activation was shown to be retained after emotional pain stress for a long enough period of time.
Positive_regulation (activation) of LPO associated with stress, pain and emotional pain
2) Confidence 0.70 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 7470598 Disease Relevance 0.45 Pain Relevance 0.26
UV spectroscopy, polarography and fluorescence of Schiff's bases were used to study the time course of emotional pain stress-induced accumulation of the primary and secondary products of lipoperoxidation (LPO) in different tissues of Wistar rats and to appraise the effect of gamma-hydroxybutyric acid (GHBA) and 4-methyl-2,6-ditretbutylphenol (ionol) on LPO induction.
Positive_regulation (induction) of LPO associated with stress, pain and emotional pain
3) Confidence 0.70 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 7470598 Disease Relevance 0.46 Pain Relevance 0.27
Stress is shown to induce at first the generalized inhibition of lipid peroxidation (LPO), and then the activation of LPO.
Positive_regulation (activation) of LPO associated with stress
4) Confidence 0.70 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3207869 Disease Relevance 0.35 Pain Relevance 0
Intravenous injection of synthetic analogues of enkephalins before LPO activation inhibited LPO and resulted in prostacyclin synthesis normalization.
Positive_regulation (activation) of LPO associated with enkephalin
5) Confidence 0.69 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1290811 Disease Relevance 0 Pain Relevance 0.17
Postoperative complications and severe outcome in patients with gallstone disease are associated with a significant increase in LPO level in serum before reoperation.
Positive_regulation (increase) of LPO associated with postoperative complications, disease and gallstones
6) Confidence 0.60 Published 1998 Journal Vopr. Med. Khim. Section Abstract Doc Link 10599144 Disease Relevance 0.86 Pain Relevance 0.08
These results suggest that SNT was not a strong enough stimulus to deplete all antioxidant content in the spinal cord, since increase in LPO was not detected.
Positive_regulation (increase) of LPO in spinal cord associated with spinal cord
7) Confidence 0.59 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16770731 Disease Relevance 0.46 Pain Relevance 0.41
In addition, there was a significant increase in LPO levels in the diabetic rat brain compared to control rat brains.
Positive_regulation (increase) of LPO in brain
8) Confidence 0.57 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.07 Pain Relevance 0
All parameters of LPO were increased both in the platelets and the plasma.
Positive_regulation (increased) of LPO in plasma
9) Confidence 0.51 Published 1989 Journal Kardiologiia Section Abstract Doc Link 2542685 Disease Relevance 0.36 Pain Relevance 0.26
Also, CCl4 showed a significant increase in serum sialic acid; nitrite levels; total LDH activity and hepatic malondialdehyde (LPO) level compared to normal control value.
Positive_regulation (increase) of LPO
10) Confidence 0.49 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0 Pain Relevance 0
Significant increases in LPO during diabetes show the occurrence of oxidative damage in diabetic rats.
Positive_regulation (increases) of LPO associated with diabetes mellitus
11) Confidence 0.48 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.51 Pain Relevance 0.09
Concomitant treatment of rats with sulphated polysaccharides significantly (P < 0.001) reduced the elevated levels of LPO, 8-OHdG and protein carbonyl close to that of controls, thereby strongly confirming its potential in inhibiting the oxidation of macromolecules like lipids, DNA and proteins.


Positive_regulation (elevated) of LPO
12) Confidence 0.48 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.09 Pain Relevance 0
UV spectroscopy, polarography and fluorescence of Schiff's bases were used to study the time course of emotional pain stress-induced accumulation of the primary and secondary products of lipoperoxidation (LPO) in different tissues of Wistar rats and to appraise the effect of gamma-hydroxybutyric acid (GHBA) and 4-methyl-2,6-ditretbutylphenol (ionol) on LPO induction.
Positive_regulation (accumulation) of LPO associated with stress, pain and emotional pain
13) Confidence 0.47 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 7470598 Disease Relevance 0.44 Pain Relevance 0.26
Carnosine given before stress prevents LPO activation.
Positive_regulation (activation) of LPO associated with stress
14) Confidence 0.47 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2923966 Disease Relevance 0.44 Pain Relevance 0.09
Pretreatment with GHBA or ionol completely reverses LPO activation.
Positive_regulation (activation) of LPO
15) Confidence 0.47 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 7470598 Disease Relevance 0.42 Pain Relevance 0.25
This is evident from increased LPO, 8-OHdG and protein carbonyls; hallmarks of lipid, DNA and protein damage, in the CsA administered Group II animals.
Positive_regulation (increased) of LPO
16) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.31 Pain Relevance 0
The hepatic tissue of CsA treated rats showed a remarkable increase in LPO, 8-OHdG and protein carbonyls, when compared with the control.
Positive_regulation (increase) of LPO
17) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.14 Pain Relevance 0
After painful stress (footshock during 2 hours) LPO products are accumulated in brain and serum, cholesterol: phospholipid ratio increases and the portion of easy oxidizable phospholipids decreases.
Positive_regulation (accumulated) of LPO in brain associated with stress and pain
18) Confidence 0.41 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2923966 Disease Relevance 0.43 Pain Relevance 0.10
In brain and blood serum of rats subjected to continuous footshock as well as to restraint stress LPO products decreased and superoxide scavenging activity increased during the initial period of stress, after 1 hour of footshock LPO indices nearly reached normal values, and after 2 hours of footshock the accumulation of LPO products and decrease of superoxide scavenging activity were seen.
Positive_regulation (accumulation) of LPO in brain associated with stress
19) Confidence 0.41 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3207869 Disease Relevance 0.41 Pain Relevance 0.06
Acetaminophen induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST).
Positive_regulation (induced) of LPO associated with glutamate and paracetamol
20) Confidence 0.39 Published 2008 Journal Pak J Pharm Sci Section Abstract Doc Link 18166521 Disease Relevance 0.17 Pain Relevance 0.39

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