INT51944

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 1.96
Pain Relevance 4.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
caudate putamen 4
hippocampal formation 2
brain 2
forebrains 2
dorsal root ganglia 2
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 100.00 Very High Very High Very High
depression 12 99.56 Very High Very High Very High
cerebral cortex 18 98.04 Very High Very High Very High
amygdala 39 97.40 Very High Very High Very High
Dopamine 212 96.88 Very High Very High Very High
agonist 41 95.76 Very High Very High Very High
antagonist 14 95.28 Very High Very High Very High
fluoxetine 1 94.24 High High
Hippocampus 155 94.00 High High
Clonidine 7 91.12 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 87 100.00 Very High Very High Very High
Depression 12 99.56 Very High Very High Very High
Death 3 80.16 Quite High
Frailty 1 79.56 Quite High
Apoptosis 4 76.12 Quite High
Injury 10 67.28 Quite High
Disease 9 53.32 Quite High
Cicatrix 2 39.72 Quite Low
Sleep Disorders 6 34.36 Quite Low
Amnesia 12 33.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Positive_regulation (present) of Transcription (levels) of NGFI-A in caudate putamen associated with antagonist, agonist and amygdala
1) Confidence 0.49 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.70
In contrast, propofol significantly reduced the transcription of Egr-1 in all concentrations including both lower concentration of 5.6 ?
Positive_regulation (concentrations) of Transcription (transcription) of Egr-1
2) Confidence 0.48 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
M propofol resulted in a significantly lower c-Fos (49% ± 12%; P = 0.024, N = 3) and higher Egr-1 (39% ± 7%; P = 0.046, N = 3) gene transcription compared to propofol treatment alone.
Positive_regulation (resulted) of Transcription (transcription) of Egr-1
3) Confidence 0.48 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
minutes after reaching state criterion was the induction kinetics of arc and zif-268 mRNA, characterized by a bell-shaped profile that peaks 30?
Positive_regulation (induction) of Transcription (kinetics) of zif-268 associated with aids-related complex
4) Confidence 0.46 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.19 Pain Relevance 0
minutes to reach maximum arc/zif-268 mRNA levels with reference to the moment when criterion was reached.
Positive_regulation (maximum) of Transcription (levels) of zif-268 associated with aids-related complex
5) Confidence 0.46 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.19 Pain Relevance 0
NGFI-A mRNA expression increased profoundly in the hippocampal formation and the cerebral cortex after all drug treatments, especially after moclobemide treatment (77-122% increase); with the exception of buspirone.
Positive_regulation (increased) of Transcription (expression) of NGFI-A in hippocampal formation associated with cerebral cortex
6) Confidence 0.45 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.29
Methoxyidazoxan enhanced NGFI-A and c-fos mRNA expression after FCL(SD), but reduced c-jun.
Positive_regulation (enhanced) of Transcription (expression) of NGFI-A associated with depression
7) Confidence 0.45 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.60 Pain Relevance 0.67
In this study, we investigated the ability of propofol to induce the transcription of c-Fos and Egr-1 in rat hippocampal brain slices.
Spec (investigated) Positive_regulation (induce) of Transcription (transcription) of Egr-1 in brain
8) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.06 Pain Relevance 0.19
METH administration caused increases in the expression of c-fos, Egr1, and Nor-1 on the intact side.
Positive_regulation (increases) of Transcription (expression) of Egr1
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001483 Disease Relevance 0.05 Pain Relevance 0.52
METH administration caused increases in the expression of c-fos, Egr1, and Nor-1 on the intact side.
Positive_regulation (caused) of Transcription (expression) of Egr1
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001483 Disease Relevance 0.05 Pain Relevance 0.52
The mRNA levels of zif268 were increased in the forebrains of rats in the Ensure cues group (Figure 4).
Positive_regulation (increased) of Transcription (levels) of zif268 in forebrains
11) Confidence 0.31 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.51 Pain Relevance 0.36
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Positive_regulation (present) of in piriform cortex Transcription (levels) of NGFI-A in caudate putamen associated with antagonist, agonist and amygdala
12) Confidence 0.17 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.70
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Positive_regulation (present) of in amygdala Transcription (levels) of NGFI-A in caudate putamen associated with antagonist, agonist and amygdala
13) Confidence 0.17 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.70
Moreover, Heumann and co-workers [54] have observed an increased level of nerve growth factor protein and mRNA in non neuronal cells surrounding the axons of sensory and motor neurons and Levy and co-workers [18] showed increased levels of FGF-2 in the dorsal root ganglia satellite cells surrounding the cell bodies of axotomyzed peripheral sensory neurons.
Positive_regulation (increased) of Transcription (level) of nerve growth factor protein in dorsal root ganglia associated with nerve growth factor
14) Confidence 0.15 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.30 Pain Relevance 0.05

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