INT51947

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.15
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
forebrain 4
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 5 100.00 Very High Very High Very High
agonist 8 97.28 Very High Very High Very High
antagonist 8 96.80 Very High Very High Very High
cerebral cortex 4 91.36 High High
anesthesia 25 90.72 High High
Clonidine 4 68.16 Quite High
bDMF 5 63.84 Quite High
amygdala 4 41.76 Quite Low
Versed 10 40.76 Quite Low
long-term potentiation 35 38.08 Quite Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 2 85.16 High High
Shock 2 66.24 Quite High
Urological Neuroanatomy 8 50.00 Quite Low
Aids-related Complex 5 35.72 Quite Low
Sleep Disorders 10 14.32 Low Low
Amnesia 20 13.36 Low Low
Depression 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Poisoning 4 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further probe the dose-dependence of c-Fos and Egr-1 transcription on propofol concentration, we exposed the hippocampal slices to increasing concentrations of propofol for 60 min.
Regulation (dependence) of Transcription (transcription) of Egr-1 associated with addiction
1) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.05
Pretreatment of hippocampal slices with RAS, RAF, MEK, ERK or p38-MAPK inhibitors for 60 min did not significantly change the transcription of c-Fos or Egr-1.
Neg (not) Regulation (change) of Transcription (transcription) of Egr-1
2) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
In contrast, propofol caused a time and concentration dependant down regulation of Egr-1 transcription and was completely inhibited at 60 min and remained inhibited for up to 240 min for all concentrations.
Regulation (regulation) of Transcription (transcription) of Egr-1
3) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.03
The present study further investigated the role of the NAergic system in mediating cortical IEG expression and possible topographical changes in expression of NGFI-A mRNA in rat forebrain after alpha 1- and alpha 2-adrenoceptor (AR) agonist and antagonist treatment.
Spec (possible) Regulation (changes) of Transcription (expression) of NGFI-A in forebrain associated with antagonist and agonist
4) Confidence 0.26 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.35
The present study further investigated the role of the NAergic system in mediating cortical IEG expression and possible topographical changes in expression of NGFI-A mRNA in rat forebrain after alpha 1- and alpha 2-adrenoceptor (AR) agonist and antagonist treatment.
Spec (investigated) Regulation (role) of Transcription (expression) of NGFI-A in forebrain associated with antagonist and agonist
5) Confidence 0.26 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.35
The changes in transcription of c-Fos and Egr-1 relied on the p38 mitogen-activated protein kinase (p38-MAPK)/ERK signaling cascade.
Regulation (changes) of Transcription (transcription) of Egr-1
6) Confidence 0.26 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.09
To investigate the effect of propofol on the transcription of c-Fos and Egr-1, we exposed the hippocampal slices to varying concentrations of propofol at increasing time intervals.
Spec (investigate) Regulation (effect) of Transcription (transcription) of Egr-1
7) Confidence 0.26 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
In contrast, for permethrin no change in the expression of c-fos and Egr1 mRNA was observed across dose groups in the qRT-PCR cohort.
Neg (no) Regulation (change) of Transcription (expression) of Egr1
8) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.15 Pain Relevance 0.09

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