INT5195

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 14.45
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 2
duodenum 2
stomach 2
macrophages 1
erythrocytes 1
Lpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 34 100.00 Very High Very High Very High
Sciatic nerve 3 100.00 Very High Very High Very High
Clonidine 2 99.66 Very High Very High Very High
agonist 2 99.46 Very High Very High Very High
aspirin 8 99.32 Very High Very High Very High
ketamine 3 99.26 Very High Very High Very High
Inflammation 59 98.72 Very High Very High Very High
cytokine 13 98.20 Very High Very High Very High
anesthesia 11 98.12 Very High Very High Very High
noradrenaline 3 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 92 99.76 Very High Very High Very High
Diabetes Mellitus 289 99.58 Very High Very High Very High
Middle Cerebral Artery Infarction 19 99.04 Very High Very High Very High
Body Weight 63 98.88 Very High Very High Very High
INFLAMMATION 64 98.72 Very High Very High Very High
Adhesions 17 98.00 Very High Very High Very High
Injury 78 97.72 Very High Very High Very High
Pain 7 97.20 Very High Very High Very High
Cv General 3 Under Development 1 95.56 Very High Very High Very High
Hyperalgesia 6 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of carnosine and stress are not additive: LPO inhibition induced by carnosine is much more in rats subjected to stress.
Negative_regulation (inhibition) of LPO associated with stress
1) Confidence 0.59 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2923966 Disease Relevance 0.53 Pain Relevance 0.09
The data suggest that the stage of LPO inhibition precedes its activation during stress.
Negative_regulation (inhibition) of LPO associated with stress
2) Confidence 0.59 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3207869 Disease Relevance 0.47 Pain Relevance 0.10
Intravenous injection of synthetic analogues of enkephalins before LPO activation inhibited LPO and resulted in prostacyclin synthesis normalization.
Negative_regulation (inhibited) of LPO associated with enkephalin
3) Confidence 0.58 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1290811 Disease Relevance 0 Pain Relevance 0.17
The "mixed inhibitors" BW755C and phenidone were approximately equipotent inhibitors of LPO activity but BW755C was 10 times more potent than phenidone against CO activity.
Negative_regulation (inhibitors) of LPO
4) Confidence 0.57 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.51 Pain Relevance 0.37
The NSAIDs flurbiprofen and indomethacin inhibited cell recruitment, exudate volume and CO activity with ED50S of approximately 1 mg per kg p.o. but failed to inhibit LPO activity at 10 mg per kg p.o.
Negative_regulation (inhibit) of LPO associated with cinod
5) Confidence 0.57 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.47 Pain Relevance 0.36
The level of LPO was reduced, but not completely halted, by treatment with gabapentin.
Negative_regulation (reduced) of LPO
6) Confidence 0.48 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.06 Pain Relevance 0
In contrast, [Met]enkephalin may be amnestic when administered in the LPO but not in the IMHV.
Negative_regulation (administered) of LPO associated with enkephalin
7) Confidence 0.42 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9109629 Disease Relevance 0 Pain Relevance 1.10
Training decreased [Met]enkephalin concentration in the LPO but not in the IMHV.
Negative_regulation (decreased) of LPO associated with enkephalin
8) Confidence 0.42 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9109629 Disease Relevance 0 Pain Relevance 1.12
Nafazatrom (Bayer 6575), quercetin and NDGA, which inhibit LPO activity in vitro, were inactive against all parameters when dosed at 100 mg per kg p.o.
Negative_regulation (inhibit) of LPO
9) Confidence 0.42 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.46 Pain Relevance 0.35
Stress is shown to induce at first the generalized inhibition of lipid peroxidation (LPO), and then the activation of LPO.
Negative_regulation (inhibition) of LPO associated with stress
10) Confidence 0.38 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3207869 Disease Relevance 0.35 Pain Relevance 0
LPO inhibition was accompanied by accumulation of easy oxidizable brain phospholipids and by depletion of brain cholesterol, during LPO activation brain cholesterol content and cholesterol-phospholipid ratio increased.
Negative_regulation (inhibition) of LPO in brain
11) Confidence 0.38 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3207869 Disease Relevance 0.40 Pain Relevance 0.07
The addition of peptides under study into perfusion solution led to a decrease in LPO primary products level and in thromboxane synthesis.
Negative_regulation (decrease) of LPO
12) Confidence 0.37 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1290811 Disease Relevance 0 Pain Relevance 0.17
In the duodenum of the diabetic+zinc sulfate group, LPO levels also decreased as compared to the diabetic group.
Negative_regulation (decreased) of LPO in duodenum associated with diabetes mellitus
13) Confidence 0.34 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.49 Pain Relevance 0.03
Oxymetazoline, being hydrophilic, was ineffective injected into IMHV, whereas the action of the lipophilic alpha(2)-adrenoceptor agonist clonidine in the IMHV was interpreted as an action at a site more distal in the brain, probably the LPO.
Negative_regulation (interpreted) of LPO in brain associated with agonist and clonidine
14) Confidence 0.34 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12871653 Disease Relevance 0.08 Pain Relevance 0.43
Pretreatment of rats with CQ significantly decreased LPO and increased the antioxidant activities.


Negative_regulation (decreased) of LPO
15) Confidence 0.33 Published 2010 Journal Indian Journal of Pharmacology Section Abstract Doc Link PMC2991701 Disease Relevance 0.14 Pain Relevance 0
Coprostanol and naproxen were more potent to reduce LPO while novobiocin and sulfapyridine were the most potent to induce LPO.
Negative_regulation (reduce) of LPO
16) Confidence 0.32 Published 2006 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 16533621 Disease Relevance 0 Pain Relevance 0.31
When the same doses of octacosanol (50 or 100 mg/kg BW) were given to CCl4-untreated rats, both a significant decrease in LPO concentration and a significant increase in GSH concentration were found in the liver tissue (Fig. 2).
Negative_regulation (decrease) of LPO in liver associated with body weight
17) Confidence 0.32 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.69 Pain Relevance 0.07
Levels of LPO in the injured sciatic nerves were significantly reduced using either early or late treatment, however tirilazad had opposing effects on recovery, prolonging or alleviating thermal hyperalgesia, respectively.
Negative_regulation (reduced) of LPO in sciatic nerves associated with thermal hyperalgesia and sciatic nerve
18) Confidence 0.31 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11498276 Disease Relevance 0.55 Pain Relevance 0.51
In the stomach of the diabetic +zinc sulfate group, LPO and NEG levels decreased as compared to the diabetic group.
Negative_regulation (decreased) of LPO in stomach associated with diabetes mellitus
19) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.47 Pain Relevance 0.05
Administration of zinc sulfate was found to reduce stomach LPO levels in diabetic rats, but in the nondiabetic control groups, it significantly increased the stomach LPO levels (ap<0.0001).
Negative_regulation (reduce) of LPO in stomach associated with diabetes mellitus
20) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.61 Pain Relevance 0.07

General Comments

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