INT51952

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 2003
Negated 0
Speculated 1
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 0.29
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
hypothalamus 3
brain 2
choroid plexus 1
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
excitatory amino acid 1 100.00 Very High Very High Very High
narcan 5 99.62 Very High Very High Very High
Morphine 15 97.84 Very High Very High Very High
tolerance 3 89.08 High High
Hippocampus 3 87.40 High High
Intracerebroventricular 3 65.20 Quite High
Disease Link Frequency Relevance Heat
Infection 1 96.84 Very High Very High Very High
Stress 3 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased binding of growth hormone in the rat hypothalamus and choroid plexus following morphine treatment.
Negative_regulation (Decreased) of growth hormone Binding (binding) of in hypothalamus associated with morphine
1) Confidence 0.46 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.49
The decrease in growth hormone-binding in these regions of the rat brain was also confirmed by SDS-polyacrylamide gel electrophoresis of cross-linked complexes of the binding entities to 125I-labelled rGH as visualized by autoradiography.
Negative_regulation (decrease) of growth hormone Binding (binding) of in brain
2) Confidence 0.29 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.52
Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress.
Spec (possible) Negative_regulation (inhibits) of gonadotropin-releasing hormone Spec (possible) Binding (interaction) of associated with stress, narcan, opioid, infection and excitatory amino acid
3) Confidence 0.27 Published 2003 Journal J. Neuroendocrinol. Section Title Doc Link 12716406 Disease Relevance 0.29 Pain Relevance 0.31
Decreased binding of growth hormone in the rat hypothalamus and choroid plexus following morphine treatment.
Negative_regulation (Decreased) of growth hormone in choroid plexus Binding (binding) of in hypothalamus associated with morphine
4) Confidence 0.16 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.49

General Comments

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