INT51957

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hsd17b1) oxidoreductase activity (Hsd17b1) cytoplasm (Hsd17b1)
Anatomy Link Frequency
substantia gelatinosa 1
Hsd17b1 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 4 99.98 Very High Very High Very High
substantia gelatinosa 4 99.72 Very High Very High Very High
Antinociceptive 2 98.56 Very High Very High Very High
antinociception 4 97.56 Very High Very High Very High
Nicotine 6 97.52 Very High Very High Very High
Spinal cord 3 96.88 Very High Very High Very High
antagonist 9 93.60 High High
Hyperalgesia 2 91.60 High High
Calcium channel 1 90.24 High High
GABAergic 1 90.08 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 91.60 High High
Hypothermia 1 89.48 High High
Targeted Disruption 1 86.96 High High
Nociception 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal injection of DH beta E was also effective in blocking the antinociceptive effect of nicotine.
Negative_regulation (injection) of DH beta E associated with nicotine, antinociceptive and intrathecal
1) Confidence 0.43 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7724704 Disease Relevance 0.09 Pain Relevance 0.80
In whole-cell patch-clamp experiments in spinal cord slice preparation from adult mice, the frequency of miniature inhibitory postsynaptic currents (mIPSCs) observed in substantia gelatinosa (SG) neurons was decreased by mecamylamine and DHbetaE, but not by MLA.
Negative_regulation (decreased) of DHbetaE in substantia gelatinosa associated with substantia gelatinosa and spinal cord
2) Confidence 0.05 Published 2006 Journal Pain Section Abstract Doc Link 16781069 Disease Relevance 0.40 Pain Relevance 0.95

General Comments

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