INT51980

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.89
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.49
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
plasma 1
respiratory 1
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
analgesia 11 99.48 Very High Very High Very High
Inflammation 27 98.84 Very High Very High Very High
substance P 2 98.28 Very High Very High Very High
bradykinin 4 97.60 Very High Very High Very High
tolerance 1 93.52 High High
tail-flick 1 90.96 High High
Endogenous opioid 1 89.76 High High
metalloproteinase 1 82.72 Quite High
Hyperalgesia 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 88 99.00 Very High Very High Very High
INFLAMMATION 29 98.84 Very High Very High Very High
Respiratory Disease 1 96.84 Very High Very High Very High
Targeted Disruption 174 92.48 High High
Stress 3 92.48 High High
Hyperalgesia 3 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 75.00 Quite High
Sepsis 2 73.00 Quite High
Toxicity 5 72.72 Quite High
Nociception 1 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to examine the effect of SCH 32615, an inhibitor of one of the enzymes (enkephalinase) responsible for the degradation of endogenous enkephalins, on pregnancy-induced analgesia in mice.
Protein_catabolism (degradation) of enkephalinase associated with enkephalin and analgesia
1) Confidence 0.89 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7726437 Disease Relevance 0 Pain Relevance 0.52
The purpose of this study was to determine whether surgery evokes analgesia and to examine the effect of SCH 32615, an inhibitor of one of the enzymes (enkephalinase) responsible for the degradation of enkephalins, on this analgesia, in mice.
Protein_catabolism (degradation) of enkephalinase associated with enkephalin and analgesia
2) Confidence 0.89 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7741304 Disease Relevance 0.18 Pain Relevance 0.64
This downregulation of NEP activity may contribute to the inactivation of the tachykinins degradation pathway and to uncontrolled inflammation in ALI/ARDS, and in other neurogenic respiratory diseases [9,24-26].
Protein_catabolism (degradation) of NEP in respiratory associated with inflammation, adult respiratory distress syndrome and respiratory disease
3) Confidence 0.88 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.17 Pain Relevance 0.05
Neutral endopeptidase (EC3.4.24.11, NEP, enkephalinase) is a zinc-metalloendopeptidase, cleaving a variety of substrates like enkephalins, substance P, and bradykinin.
Protein_catabolism (cleaving) of enkephalinase associated with enkephalin, bradykinin and substance p
4) Confidence 0.38 Published 2002 Journal J. Mol. Neurosci. Section Abstract Doc Link 11931342 Disease Relevance 0.48 Pain Relevance 0.78
Neprilysin (or neutral endopeptidase 24.11 = NEP or CD10 or enkephalinase) is thought to be at least partly responsible for the degradation of A?
Protein_catabolism (degradation) of Neprilysin
5) Confidence 0.20 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.59 Pain Relevance 0.07
METHODS: We measured plasma levels of ET-1, C-terminal degradation products of ET-1, and neutral endopeptidase 24.11 (NEP) in 68 patients with acute Q-wave myocardial infarction and 29 control subjects.
Protein_catabolism (degradation) of neutral endopeptidase 24.11 in plasma
6) Confidence 0.02 Published 2001 Journal Ann Emerg Med Section Body Doc Link 11326179 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox