INT51986

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.40
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk2) extracellular space (Pcsk2)
Anatomy Link Frequency
Brains 2
Pcsk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 41 100.00 Very High Very High Very High
analgesia 5 99.82 Very High Very High Very High
Neuropeptide 22 99.72 Very High Very High Very High
Enkephalin 10 99.16 Very High Very High Very High
Pain 4 99.14 Very High Very High Very High
nociceptor 1 99.14 Very High Very High Very High
Somatostatin 6 98.20 Very High Very High Very High
Opioid 11 97.40 Very High Very High Very High
Central nervous system 15 78.80 Quite High
Neurotransmitter 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.96 Very High Very High Very High
Syndrome 3 99.86 Very High Very High Very High
Stress 6 99.46 Very High Very High Very High
Obesity 57 99.22 Very High Very High Very High
Pain 1 98.68 Very High Very High Very High
Nociception 2 92.12 High High
Hypoglycemia 1 53.60 Quite High
Anorexia 14 5.00 Very Low Very Low Very Low
Appetite Loss 10 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brains of heterozygous mice exhibit only half the PC2 activity of wild-type mice; however, the levels of Dyn peptides in these mice are similar to those of wild-type mice, suggesting that a 50% reduction in PC2 activity is not sufficient to significantly reduce prodynorphin processing.
Negative_regulation (reduction) of PC2 in Brains associated with dynorphin
1) Confidence 0.50 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.51
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.
Negative_regulation (lacking) of PC2 associated with stress, neuropeptide and analgesia
2) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16905251 Disease Relevance 0.45 Pain Relevance 1.21
Defective prodynorphin processing in mice lacking prohormone convertase PC2.
Negative_regulation (lacking) of PC2 associated with enkephalin
3) Confidence 0.42 Published 2000 Journal J. Neurochem. Section Title Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.58
The absence of active PC2 resulted in altered cellular levels of NPY, somatostatin-28, and (Met)enkephalin; few changes in VIP or galanin occurred in the tissues examined.
Negative_regulation (absence) of PC2 associated with somatostatin and enkephalin
4) Confidence 0.37 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.79
Enzymological and immunological assays were used to confirm the absence of active PC2 in these mice.
Negative_regulation (absence) of PC2
5) Confidence 0.37 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.50
Synthetic peptides were used to demonstrate that the 7B2 CT-peptide (a) represents a potent inhibitor of PC2 (Ki = 57 nM), (b) can block the conversion of proPC2 to PC2, and (c) can block the PC2-mediated conversion of proenkephalin to smaller peptide fragments.
Negative_regulation (inhibitor) of PC2
6) Confidence 0.35 Published 1995 Journal Biochemistry Section Abstract Doc Link 7727407 Disease Relevance 0.05 Pain Relevance 0
Comparative studies of PC1/3 and PC2 convertases showed that PC1/3 knockout mouse brains had a modest decrease in dynorphin A, and PC2 knockout mice showed a minor decrease in alpha-neoendorphin.
Negative_regulation (decrease) of PC2 in brains associated with targeted disruption and dynorphin
7) Confidence 0.18 Published 2010 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19837164 Disease Relevance 0.35 Pain Relevance 0.48
Subjects with the human genetic obesity disorder, Prader-Willi syndrome, have reduced levels of PC2 in their hypothalami on immunocytochemical assessment [39].
Negative_regulation (reduced) of PC2 associated with syndrome and obesity
8) Confidence 0.08 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.04

General Comments

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