INT5199

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 44
Total Number 45
Disease Relevance 8.66
Pain Relevance 24.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
spinal cord 9
neurons 8
paw 3
medulla 2
striatum 2
Fosl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 1 99.92 Very High Very High Very High
medulla 42 99.88 Very High Very High Very High
Spinal cord 46 99.84 Very High Very High Very High
orphanin 18 99.84 Very High Very High Very High
Gabapentin 16 99.84 Very High Very High Very High
Thermal hyperalgesia 3 99.82 Very High Very High Very High
agonist 75 99.64 Very High Very High Very High
Dopamine 53 99.60 Very High Very High Very High
Dorsal horn neuron 6 99.36 Very High Very High Very High
Glutamate receptor 9 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 10 99.92 Very High Very High Very High
Mesothelioma 220 99.84 Very High Very High Very High
Stress 19 99.84 Very High Very High Very High
Nociception 34 99.82 Very High Very High Very High
Hyperalgesia 8 99.82 Very High Very High Very High
Neuropathic Pain 11 97.96 Very High Very High Very High
Congenital Anomalies 1 97.96 Very High Very High Very High
Hypoalagesia 1 97.60 Very High Very High Very High
Injury 5 95.96 Very High Very High Very High
Facial Pain 1 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional heterogeneity in dopamine release and in the expression of Fos-like proteins within the rat striatal complex.
Gene_expression (expression) of Fos-like associated with dopamine
1) Confidence 0.78 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10103112 Disease Relevance 0.15 Pain Relevance 0.50
In this case, adrenalectomy increased cocaine-induced changes in extracellular dopamine but did not modify the expression of Fos-like proteins.
Gene_expression (expression) of Fos-like associated with dopamine and cocaine
2) Confidence 0.73 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207816 Disease Relevance 0 Pain Relevance 0.72
The reduction of the expression of Fos-like immunoreactivity by exogenous morphine speaks in favour of an opioidergic link in the modulation of orofacial pain in the trigeminal nuclei.
Gene_expression (expression) of Fos-like associated with face pain and morphine
3) Confidence 0.71 Published 1995 Journal Brain Res. Section Abstract Doc Link 7614003 Disease Relevance 0.18 Pain Relevance 0.83
We conclude that the peripheral noxious inputs (which ascend via the ventral half of the spinal cord in this study) can activate the supraspinal descending inhibitory systems, which in turn suppress the synthesis of Fos-like protein in the related dorsal horn neurons.
Gene_expression (synthesis) of Fos-like protein in spinal cord associated with dorsal horn neuron and spinal cord
4) Confidence 0.71 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152541 Disease Relevance 0.05 Pain Relevance 0.21
Basal increase in c-Fos-like expression in superior colliculus of Royal College of Surgeons dystrophic rats can be abolished by intraocular injection of tetrodotoxin.
Gene_expression (expression) of Fos-like in superior colliculus associated with tetrodotoxin
5) Confidence 0.68 Published 2001 Journal Neuroscience Section Title Doc Link 11744251 Disease Relevance 0 Pain Relevance 0.19
However, pre-administration of a higher dose of morphine (3 mg/kg) significantly reduced the total number of Fos-like immunoreactive neurons (28 +/- 8% reduction, P < 0.001, as compared with control carrageenin Fos-like immunoreactive expression), with this effect being equally divided between the superficial and deep laminae (29 +/- 5 and 29 +/- 6% reduction, respectively, P < 0.001, as compared with control carrageenin Fos-like immunoreactive expression, for both).
Gene_expression (expression) of Fos-like in neurons associated with morphine
6) Confidence 0.67 Published 1995 Journal Neuroscience Section Abstract Doc Link 7675199 Disease Relevance 0 Pain Relevance 0.48
However, pre-administration of a higher dose of morphine (3 mg/kg) significantly reduced the total number of Fos-like immunoreactive neurons (28 +/- 8% reduction, P < 0.001, as compared with control carrageenin Fos-like immunoreactive expression), with this effect being equally divided between the superficial and deep laminae (29 +/- 5 and 29 +/- 6% reduction, respectively, P < 0.001, as compared with control carrageenin Fos-like immunoreactive expression, for both).
Gene_expression (expression) of Fos-like in neurons associated with morphine
7) Confidence 0.67 Published 1995 Journal Neuroscience Section Abstract Doc Link 7675199 Disease Relevance 0 Pain Relevance 0.48
By contrast, many enkephalinergic neurons did express Fos-like protein in response to glutamatergic stimulation. 5.
Gene_expression (express) of Fos-like in neurons
8) Confidence 0.65 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0 Pain Relevance 1.33
Both the indirect monoamine agonists and the glutamate receptor agonist stimulated rapid nuclear expression of Fos-like protein in specific classes of striatal neurons.
Gene_expression (expression) of Fos-like in neurons associated with glutamate receptor, agonist and monoamine
9) Confidence 0.65 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1359024 Disease Relevance 0.07 Pain Relevance 1.30
Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum.
Gene_expression (expression) of Fos-like in striatum associated with glutamate, dopamine and agonist
10) Confidence 0.65 Published 1992 Journal J. Neurophysiol. Section Title Doc Link 1359024 Disease Relevance 0.09 Pain Relevance 1.13
Unlike its inhibition of formalin-evoked nociceptive behaviors, the effect of gabapentin on the expression of Fos-like immunoreactivity in the spinal cord was highly dependent on the concentration of formalin.
Gene_expression (expression) of Fos-like in spinal cord associated with nociception, gabapentin and spinal cord
11) Confidence 0.60 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10640314 Disease Relevance 0.41 Pain Relevance 1.04
Formalin injection into the hindpaw of the rat induces the nocifensive flinching behavior and the expression of Fos-like immunoreactivity (Fos-LI) in the spinal cord.
Gene_expression (expression) of Fos-like immunoreactivity in spinal cord associated with spinal cord
12) Confidence 0.60 Published 2002 Journal Life Sci. Section Abstract Doc Link 12052441 Disease Relevance 0 Pain Relevance 0.63
Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat.
Gene_expression (expression) of Fos-like in spinal cord associated with nociception, analgesic, gabapentin and spinal cord
13) Confidence 0.60 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10640314 Disease Relevance 0.42 Pain Relevance 1.08
Sevoflurane suppresses noxious stimulus-evoked expression of Fos-like immunoreactivity in the rat spinal cord via activation of endogenous opioid systems.
Gene_expression (expression) of Fos-like immunoreactivity in spinal cord associated with analgesic, endogenous opioid and spinal cord
14) Confidence 0.60 Published 2002 Journal Life Sci. Section Title Doc Link 12052441 Disease Relevance 0 Pain Relevance 0.86
Noxious heating of the hindpaw significantly increased the mean number of neurons expressing Fos-like immunoreactivity in the contralateral ventrolateral medulla.
Gene_expression (expressing) of Fos-like in medulla associated with medulla
15) Confidence 0.60 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7608329 Disease Relevance 0.18 Pain Relevance 0.34
In contrast, in the paramedian reticular nucleus, noxious heating of the hindpaw resulted in a significant decrease in the mean number of neurons expressing Fos-like immunoreactivity.
Gene_expression (expressing) of Fos-like in neurons
16) Confidence 0.60 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7608329 Disease Relevance 0.13 Pain Relevance 0.37
No significant differences in the mean numbers of neurons expressing Fos-like immunoreactivity were noted in the A2, C1, or C2/C3 medullary catecholamine cell groups.
Gene_expression (expressing) of Fos-like in cell groups associated with catecholamine
17) Confidence 0.60 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7608329 Disease Relevance 0.13 Pain Relevance 0.37
Similarly, in the contralateral medullary dorsal reticular fields, noxious heating of the hindpaw significantly increased the mean number of neurons expressing Fos-like immunoreactivity.
Gene_expression (expressing) of Fos-like in neurons
18) Confidence 0.60 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7608329 Disease Relevance 0.15 Pain Relevance 0.38
The objectives of the present study were 1) to utilize Fos immunohistochemistry as a marker for neuronal activity in order to examine the population of neurons in the medulla that is engaged by activation of nociceptive peripheral afferents and 2) to determine whether catecholamine-containing neurons in the medulla also express noxious heat-evoked Fos-like immunoreactivity.
Gene_expression (express) of Fos-like in neurons associated with nociception, medulla and catecholamine
19) Confidence 0.60 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7608329 Disease Relevance 0.19 Pain Relevance 0.33
The direct compression of L5 nerve root produced an obvious expression of fos-like immunoreactivity neurons in the dorsal horn of the spinal cord, which was significantly decreased by pretreatment with capsaicin.
Gene_expression (expression) of fos-like in dorsal horn
20) Confidence 0.59 Published 2009 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 19781278 Disease Relevance 0 Pain Relevance 0

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