INT51990

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.01
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
brain 1
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 94.16 High High
ischemia 3 50.00 Quite Low
Pain 1 47.92 Quite Low
headache 2 47.24 Quite Low
Bioavailability 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anti-phospholipid Antibody Syndrome 8 98.84 Very High Very High Very High
Metabolic Syndrome 4 96.40 Very High Very High Very High
Diabetes Mellitus 68 95.48 Very High Very High Very High
INFLAMMATION 3 93.92 High High
Systemic Lupus Erythematosus 4 83.76 Quite High
Cardiovascular Disease 2 83.28 Quite High
Cv General 3 Under Development 1 76.60 Quite High
Cv Unclassified Under Development 3 75.28 Quite High
Thrombosis 2 68.60 Quite High
Hypoglycemia 3 63.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Ischemia led to strong upregulation of mRNA transcripts for heat shock proteins 70, 27, 105, 86 and 40 kDa, vascular endothelial growth factor, brain-derived neurotrophic factor, plasminogen activator inhibitor-1, activating transcription factor 3, B-cell translocation gene 2, and growth arrest and DNA damage inducible 45 alpha protein compared to the NI tissue.
Transcription (transcripts) of plasminogen activator inhibitor-1 in brain
1) Confidence 0.45 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12909328 Disease Relevance 0.15 Pain Relevance 0
Between the APS and the control patients no significant differences were detected in t-PA, PAI-1, vWF or AECA levels.
Transcription (detected) of PAI-1 associated with anti-phospholipid antibody syndrome
2) Confidence 0.11 Published 1995 Journal Br. J. Rheumatol. Section Abstract Doc Link 7728392 Disease Relevance 1.18 Pain Relevance 0.09
When compared with rosiglitazone/metformin, reduction in PAI-1 levels is similar after 1 year of combination treatment.
Transcription (levels) of PAI-1
3) Confidence 0.03 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012436 Disease Relevance 0.68 Pain Relevance 0

General Comments

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