INT51993

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.59
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMA5) nucleoplasm (PSMA5) peptidase activity (PSMA5)
small molecule metabolic process (PSMA5) nucleolus (PSMA5) nucleus (PSMA5)
Anatomy Link Frequency
cornea 2
macrophages 1
monocytes 1
stem 1
PSMA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 15 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
Endogenous opioid 5 97.12 Very High Very High Very High
cytokine 2 96.42 Very High Very High Very High
Dynorphin 2 86.56 High High
Analgesic 4 55.40 Quite High
Inflammation 2 54.32 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 5 99.60 Very High Very High Very High
Cancer 28 98.08 Very High Very High Very High
Apoptosis 2 86.72 High High
INFLAMMATION 2 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that GTR1 embryonic stem (ES) cells expressed cell surface kappa opioid receptors, as well as protein kinase C (PKC)-alpha, -beta1, -beta2, -delta, -epsilon, and -zeta.
Gene_expression (expressed) of zeta in stem associated with kinase c and kappa opioid receptor
1) Confidence 0.75 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623877 Disease Relevance 0 Pain Relevance 0.48
OGF and the zeta (zeta) opioid receptor were detected in human pancreatic tumor cells by immuno-cytochemistry.
Gene_expression (detected) of zeta associated with pancreatic cancer and opioid receptor
2) Confidence 0.65 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9066724 Disease Relevance 0.78 Pain Relevance 0.72
Conserved expression of the opioid growth factor, [Met5]enkephalin, and the zeta (zeta) opioid receptor in vertebrate cornea.
Gene_expression (expression) of zeta in cornea associated with opioid receptor, enkephalin and opioid
3) Confidence 0.58 Published 1995 Journal Brain Res. Section Title Doc Link 7728521 Disease Relevance 0 Pain Relevance 0.73
Conserved expression of the opioid growth factor, [Met5]enkephalin, and the zeta (zeta) opioid receptor in vertebrate cornea.
Gene_expression (expression) of zeta in cornea associated with opioid receptor, enkephalin and opioid
4) Confidence 0.58 Published 1995 Journal Brain Res. Section Title Doc Link 7728521 Disease Relevance 0 Pain Relevance 0.73
Studies showed that LF elevates the number and increases the activity of T and B lymphocytes and NK cells, stimulates the release of a number of cytokines (IL-1, -6, -8, -18, IFN-gamma, TNF alpha), increases phagocytic activity and cytotoxicity of monocytes/macrophages, accelerates the maturation of T and B cells, and elevates the expression of several types of cellular receptors, such as CD4, zeta chain of the CD3 complex, LFA-1, CD11, ICAM-1, and selectin P.
Gene_expression (expression) of zeta in macrophages associated with cytokine
5) Confidence 0.58 Published 2006 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 16885906 Disease Relevance 0.90 Pain Relevance 0.13
Studies showed that LF elevates the number and increases the activity of T and B lymphocytes and NK cells, stimulates the release of a number of cytokines (IL-1, -6, -8, -18, IFN-gamma, TNF alpha), increases phagocytic activity and cytotoxicity of monocytes/macrophages, accelerates the maturation of T and B cells, and elevates the expression of several types of cellular receptors, such as CD4, zeta chain of the CD3 complex, LFA-1, CD11, ICAM-1, and selectin P.
Gene_expression (expression) of zeta in monocytes associated with cytokine
6) Confidence 0.20 Published 2006 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 16885906 Disease Relevance 0.90 Pain Relevance 0.13

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