INT51994

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Context Info
Confidence 0.03
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.13
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
cornea 2
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 21 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Endogenous opioid 2 97.80 Very High Very High Very High
opiate 2 93.80 High High
antagonist 18 92.92 High High
agonist 24 76.56 Quite High
chemokine 17 50.00 Quite Low
Inflammation 31 5.00 Very Low Very Low Very Low
MU agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomatitis 1 71.48 Quite High
Cytomegalovirus Infection 7 53.84 Quite High
INFLAMMATION 37 5.00 Very Low Very Low Very Low
Bordatella Infection 8 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conserved expression of the opioid growth factor, [Met5]enkephalin, and the zeta (zeta) opioid receptor in vertebrate cornea.
Positive_regulation (Conserved) of Gene_expression (expression) of receptor in cornea associated with opioid receptor, enkephalin and opioid
1) Confidence 0.03 Published 1995 Journal Brain Res. Section Title Doc Link 7728521 Disease Relevance 0 Pain Relevance 0.73
Resistant clones were screened for receptor expression by immunocytochemical analysis.
Positive_regulation (screened) of Gene_expression (expression) of receptor
2) Confidence 0.01 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.07 Pain Relevance 0
In COS-7 cells transfected with the rat AT1 receptor a prototype of these compounds, L-162,313 stimulated phosphoinositide hydrolysis with an EC50 of 33 +/- 11 nM.
Positive_regulation (transfected) of Gene_expression (transfected) of receptor
3) Confidence 0.01 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7829475 Disease Relevance 0 Pain Relevance 0.25
Also, a fourth group was included, consisting of HEK293 cells transfected with empty vector, which served as control to study the changes produced by the transfection of the receptor in these cells.
Positive_regulation (transfection) of Gene_expression (transfection) of receptor
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

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