INT520

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 8.98
Pain Relevance 12.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
nucleus 2
plasma 1
erythrocytes 1
neurons 1
Comt (Rattus norvegicus)
Comt - V158M (2)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 459 100.00 Very High Very High Very High
Catecholamine 145 100.00 Very High Very High Very High
Pain 70 100.00 Very High Very High Very High
neuralgia 4 100.00 Very High Very High Very High
agonist 10 99.96 Very High Very High Very High
Neuropathic pain 16 99.84 Very High Very High Very High
Morphine 91 99.76 Very High Very High Very High
Neurotransmitter 9 99.40 Very High Very High Very High
Fibrositis 7 99.04 Very High Very High Very High
amygdala 1 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 66 100.00 Very High Very High Very High
Neuropathic Pain 16 99.84 Very High Very High Very High
Anxiety Disorder 55 99.76 Very High Very High Very High
Sprains And Strains 2 99.60 Very High Very High Very High
Fibromyalgia 2 99.04 Very High Very High Very High
Apoptosis 2 98.76 Very High Very High Very High
Affective Disorder 5 98.68 Very High Very High Very High
Nicotine Addiction 60 98.12 Very High Very High Very High
Cancer 32 98.08 Very High Very High Very High
Disease 92 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Table 3, however, the results suggest no statistically significant multiplicative nor additive interaction between COMT genotype and serum tHcy (p-values >0.05).
COMT Binding (interaction) of associated with catechol-o-methyltransferase
1) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.18 Pain Relevance 0.44
Ross et al., analysed the COMT gene and its association with the central side effects of morphine in a cancer patient cohort.
COMT Spec (analysed) Binding (association) of associated with catechol-o-methyltransferase, cancer and morphine
2) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2644687 Disease Relevance 0.64 Pain Relevance 0.85
Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters.
Catechol-O-methyltransferase Binding (metabolize) of associated with catechol-o-methyltransferase, neurotransmitter and catecholamine
3) Confidence 0.37 Published 2005 Journal Eur J Pain Section Abstract Doc Link 15862471 Disease Relevance 0.45 Pain Relevance 0.87
Our study concludes that functional Val158Met polymorphism of COMT gene is not associated to increased susceptibility to neuropathic pain.
COMT gene (V158M) Binding (associated) of associated with catechol-o-methyltransferase and neuropathic pain
4) Confidence 0.37 Published 2005 Journal Eur J Pain Section Abstract Doc Link 15862471 Disease Relevance 0.57 Pain Relevance 0.98
Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters.
COMT Binding (metabolize) of associated with catechol-o-methyltransferase, neurotransmitter and catecholamine
5) Confidence 0.37 Published 2005 Journal Eur J Pain Section Abstract Doc Link 15862471 Disease Relevance 0.45 Pain Relevance 0.87
When comparing men with both high plasma tHcy (highest third) and COMT Met158Met genotype with the men with lower serum tHcy and COMT Met158Val or Val158Val genotype, we found age and examination year adjusted HRR of 2.60 of acute coronary event (95% CI 1.35–5.03, p?
COMT Binding (genotype) of in plasma associated with catechol-o-methyltransferase
6) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.30 Pain Relevance 0.33
In order to study the interaction between serum folate levels and COMT genotypes, we conducted similar analyses with serum folate.
COMT Binding (interaction) of associated with catechol-o-methyltransferase
7) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.14 Pain Relevance 0.53
Interactions between serum homocysteine and folate, COMT Met158Met genotype and acute coronary event risk
COMT Binding (Interactions) of associated with catechol-o-methyltransferase
8) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.33 Pain Relevance 0.24
Nevertheless, the interaction between COMT genotype and serum folate was not statistically significant either on the multiplicative or additive scale (p-values >0.05).


COMT Binding (interaction) of associated with catechol-o-methyltransferase
9) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.22 Pain Relevance 0.46
RESULTS: We found that the COMT val158met polymorphism was not associated with 4-week fluoxetine therapeutic response; however, association analysis showed that patients with the COMT(Val/Val) genotype had poorer responses in the eighth week (CLUMP T1 P=0.020) and consistently showed significantly smaller reductions in HAM-D(21) scores in the eighth week (P=0.027).
COMT Binding (associated) of
10) Confidence 0.36 Published 2009 Journal J Affect Disord Section Body Doc Link 18533273 Disease Relevance 0 Pain Relevance 0
The COMT Met158 allele leads to lower COMT activity and has also been associated with anxiety, and the effect of this gene is apparently additive with HTTLPR.
COMT Binding (associated) of associated with catechol-o-methyltransferase and anxiety disorder
11) Confidence 0.36 Published 2006 Journal Neuroinformatics Section Abstract Doc Link 16595858 Disease Relevance 1.02 Pain Relevance 0.69
However, because of lack of financial and personnel resources we did not evaluated other single nucleotide polymorphisms within the COMT gene or in other genes, and as a consequence, we did not have the opportunity to evaluate haplotypes of the COMT gene or possible interaction with other genes.
COMT gene Binding (interaction) of associated with catechol-o-methyltransferase
12) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1906749 Disease Relevance 0.52 Pain Relevance 0.37
However, a number of functional polymorphisms in- or close to the COMT gene have been described, and some recent studies have looked at multiple single nucleotide polymorphisms (SNPs) and different COMT haplotypes in relation to psychiatric phenotypes [38,39], and interaction between the COMT gene and other genes [26,33].
COMT gene Binding (interaction) of associated with catechol-o-methyltransferase
13) Confidence 0.34 Published 2008 Journal BMC Psychiatry Section Body Doc Link PMC2453123 Disease Relevance 0.61 Pain Relevance 0.40
COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population.
COMT (V158M) Binding (associated) of associated with neuralgia and neuropathic pain
14) Confidence 0.32 Published 2005 Journal Eur J Pain Section Title Doc Link 15862471 Disease Relevance 0.48 Pain Relevance 1.09
OBJECTIVES: The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts.
COMT Binding (association) of associated with pain, catechol-o-methyltransferase and fibrositis
15) Confidence 0.32 Published 2010 Journal Ann. Rheum. Dis. Section Abstract Doc Link 20570835 Disease Relevance 0.35 Pain Relevance 0.35
Of the remaining 1038 men, data on serum folate and tHcy concentration and COMT genotype were available for 1012 men.
COMT Binding (genotype) of associated with catechol-o-methyltransferase
16) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.62 Pain Relevance 0.14
Another COMT inhibitor, 3,5-dihydroxy-4-methoxybenzoic acid, interacted with morphine in S-D rats to an equal degree as did tropolone.
COMT Binding (interacted) of associated with morphine
17) Confidence 0.30 Published 1979 Journal Toxicology Section Abstract Doc Link 44389 Disease Relevance 0.34 Pain Relevance 0.99
RESULTS: Analyses revealed a significant gene x experience interaction for COMT, such that individuals with met/met genotype experienced a greater decline in positive affect on days when pain was elevated than did either val/met or val/val individuals.
COMT Binding (interaction) of
18) Confidence 0.30 Published 2010 Journal Health Psychol Section Body Doc Link 20230086 Disease Relevance 0.17 Pain Relevance 0
The effect of ethanol (2 g/kg) on brain catecholamine neurons in the rat as well as its interaction with catecholamine receptor agonists was studied utilizing single unit recording techniques.
catecholamine receptor Binding (interaction) of in neurons associated with catecholamine and agonist
19) Confidence 0.28 Published 1980 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 6773308 Disease Relevance 0 Pain Relevance 0.69
Since mitochondria-associated MAO and the cytosolic COMT do not enter the nucleus, it remains to be determined how and by which mechanism intranuclear actions of catecholamines are terminated.
COMT Binding (associated) of in nucleus associated with catechol-o-methyltransferase and catecholamine
20) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.10 Pain Relevance 0.67

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