INT5200

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 26
Speculated 77
Reported most in Abstract
Documents 3083
Total Number 3161
Disease Relevance 894.43
Pain Relevance 1639.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 306
neurons 239
spinal 230
brain 196
dorsal horn 135
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6330 100.00 Very High Very High Very High
Spinal cord 6239 100.00 Very High Very High Very High
Dorsal horn 4039 100.00 Very High Very High Very High
Morphine 3595 100.00 Very High Very High Very High
amygdala 3247 100.00 Very High Very High Very High
Inflammation 3167 100.00 Very High Very High Very High
qutenza 2694 100.00 Very High Very High Very High
Nucleus accumbens 1378 100.00 Very High Very High Very High
narcan 1376 100.00 Very High Very High Very High
anesthesia 1102 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5653 100.00 Very High Very High Very High
INFLAMMATION 2932 100.00 Very High Very High Very High
Urological Neuroanatomy 1891 100.00 Very High Very High Very High
Generalized Anxiety Disorder 1292 100.00 Very High Very High Very High
Aids-related Complex 635 100.00 Very High Very High Very High
Depression 559 100.00 Very High Very High Very High
Nociception 4275 99.98 Very High Very High Very High
Stress 2364 99.96 Very High Very High Very High
Pancreatitis 625 99.96 Very High Very High Very High
Stupor 28 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regional patterns of cells with nuclei expressing Fos, plotted on a spread-out reconstruction of the mitral cell layer, were strikingly comparable to data from the 2-deoxyglucose method, by which different foci of the most-labelled glomeruli of metabolic activity were demonstrated using different odors.
Gene_expression (expressing) of Fos
1) Confidence 0.78 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1584455 Disease Relevance 0 Pain Relevance 0.10
Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain.
Gene_expression (expression) of Fos in brain associated with narcan
2) Confidence 0.78 Published 2003 Journal Neuropharmacology Section Title Doc Link 12623225 Disease Relevance 0.07 Pain Relevance 0.77
Nor-trimebutine decreased Fos expression in the thoraco-lumbar (peritoneal irritation) and lumbo-sacral (colonic inflammation) spinal cord in laminae I, IIo V, VII and X.
Gene_expression (expression) of Fos in spinal cord associated with inflammation and spinal cord
3) Confidence 0.78 Published 2005 Journal Life Sci. Section Abstract Doc Link 15978629 Disease Relevance 0.68 Pain Relevance 0.66
RESULTS: Acute fluoxetine increased the airjet-induced escape behaviour and Fos expression in the LC of saline-pretreated rats.
Gene_expression (expression) of Fos
4) Confidence 0.78 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 16521035 Disease Relevance 0 Pain Relevance 0
In laminae I-II of the L4-L5 segment, the magnitude of the decrease in Fos expression was comparable for remifentanil (26.5%) and lidocaine (27.3%); the decrease was greater when both remifentanil and lidocaine were administered (50.5%), and even greater when bupivicaine and lidocaine were used (74.2%).
Gene_expression (expression) of Fos associated with ultiva and lidocaine
5) Confidence 0.78 Published 1997 Journal Pain Section Abstract Doc Link 9060019 Disease Relevance 0.39 Pain Relevance 1.91
In addition, in the hypothalamic paraventricular nucleus (PVN), Fos expression was increased after naloxone-but not after naloxone methiodide-administration to morphine-dependent rats.
Gene_expression (expression) of Fos in nucleus associated with narcan and morphine
6) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15033383 Disease Relevance 0.06 Pain Relevance 1.43
The treatments dose dependently decreased both Fos immunoreactivity expression in dorsal horn of rat lumbar spinal cord and all nociceptive measures in the tonic phase of the formalin test. c-Fos correlated well with weighted pain score and/or flinching responses, but not with licking/biting behavior.
Gene_expression (expression) of Fos in dorsal horn associated with nociception, pain score, dorsal horn and spinal cord
7) Confidence 0.78 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9218679 Disease Relevance 0.51 Pain Relevance 0.31
Expression of the transcription factor Fos is known to increase during opiate withdrawal, but its presence during low-dose antagonist-precipitated withdrawal has not previously been established.
Gene_expression (Expression) of Fos associated with antagonist, opiate and withdrawal
8) Confidence 0.78 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11120397 Disease Relevance 0 Pain Relevance 1.19
Just over a decade has past since Hunt et al. reported that the gene c-fos and its protein product Fos are expressed in the spinal cord of rats subjected to peripheral noxious stimulation.
Gene_expression (expressed) of Fos in spinal cord associated with spinal cord
9) Confidence 0.78 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434195 Disease Relevance 0.27 Pain Relevance 0.33
These authors showed that noxious stimulation (application of radiant heat or mustard oil) to the hind paw resulted in a massive increase in the expression of Fos in neurons in the dorsal horn of the lumbar spinal cord.
Gene_expression (expression) of Fos in neurons associated with dorsal horn and spinal cord
10) Confidence 0.78 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434195 Disease Relevance 0.45 Pain Relevance 0.38
CONCLUSIONS: The finding that persistent nociceptive behaviors and Fos expression were suppressed by intrathecal lidocaine pretreatment suggests that nociception in the second phase of the formalin test depends on increases in central hyperexcitability generated during the first phase.
Gene_expression (expression) of Fos
11) Confidence 0.78 Published 1998 Journal Anesthesiology Section Body Doc Link 9447868 Disease Relevance 0.06 Pain Relevance 0
On the other hand, the finding that the intrathecal injection of lidocaine after formalin treatment reduced Fos expression but not nociceptive responses indicates an uncoupling of the behavioral and Fos protein responses to formalin and suggests that changes in Fos expression may not be a good predictor of the ability of agents to produce preemptive analgesia.


Gene_expression (expression) of Fos
12) Confidence 0.78 Published 1998 Journal Anesthesiology Section Body Doc Link 9447868 Disease Relevance 0.05 Pain Relevance 0
METHODS: Formalin-induced nociception and Fos expression in the spinal cord, in response to a 50-microl injection of 2.5% formalin into the hind paw, were assessed in rats given an intrathecal injection of 50 microl 2% lidocaine by lumbar puncture between the L5 and L6 vertebrae, either 3 min before (pretreatment) or 5 min after (post-treatment) formalin injection.
Gene_expression (expression) of Fos in spinal cord
13) Confidence 0.78 Published 1998 Journal Anesthesiology Section Body Doc Link 9447868 Disease Relevance 0.10 Pain Relevance 0
The present study examined this hypothesis by comparing the effects of intrathecal lidocaine given before and after hindpaw formalin injection on persistent nociceptive responses and Fos expression in spinal cord dorsal horn of rats.
Gene_expression (expression) of Fos in spinal cord dorsal horn associated with nociception, dorsal horn, lidocaine, spinal cord and intrathecal
14) Confidence 0.78 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9447868 Disease Relevance 0.17 Pain Relevance 0.57
On the other hand, the finding that the intrathecal injection of lidocaine after formalin treatment reduced Fos expression but not nociceptive responses indicates an uncoupling of the behavioral and Fos protein responses to formalin and suggests that changes in Fos expression may not be a good predictor of the ability of agents to produce preemptive analgesia.


Gene_expression (expression) of Fos
15) Confidence 0.78 Published 1998 Journal Anesthesiology Section Body Doc Link 9447868 Disease Relevance 0 Pain Relevance 0
BACKGROUND: It has been proposed that the measure of noxious stimulus-induced Fos (the protein product of the immediate early gene c-fos) expression in the spinal cord dorsal horn of laboratory animals may provide an estimate of the potential of specific treatments to produce preemptive analgesia.
Gene_expression (expression) of Fos in spinal cord dorsal horn associated with dorsal horn, preemptive analgesia and spinal cord
16) Confidence 0.78 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9447868 Disease Relevance 0.07 Pain Relevance 0.53
Comparison of the effects of treatment with intrathecal lidocaine given before and after formalin on both nociception and Fos expression in the spinal cord dorsal horn.
Gene_expression (expression) of Fos in spinal cord dorsal horn associated with nociception, pain, dorsal horn, lidocaine, spinal cord and intrathecal
17) Confidence 0.78 Published 1998 Journal Anesthesiology Section Title Doc Link 9447868 Disease Relevance 0.10 Pain Relevance 0.69
In the saline group, Fos expression was detected predominantly in laminae I-II and V-VI, and the total Fos expression was maximal at 1 h and then decreased gradually.
Gene_expression (expression) of Fos
18) Confidence 0.78 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.08 Pain Relevance 1.09
We investigated the spatial and temporal patterns of c-Fos protein (Fos) expression in the dorsal horn of the spinal cord caused by plantar incision in the rat and the effects of pretreatment with local anesthetics.
Gene_expression (expression) of Fos in spinal cord associated with dorsal horn, local anesthetic and spinal cord
19) Confidence 0.78 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.08 Pain Relevance 0.75
Pretreatment with local anesthetics suppressed Fos expression significantly in all layers, and this suppression continued for several days.
Gene_expression (expression) of Fos associated with local anesthetic
20) Confidence 0.78 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.13 Pain Relevance 1.27

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