INT5201

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Context Info
Confidence 0.54
First Reported 1992
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.63
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
spinal cord 6
medulla 2
paw 2
superior colliculus 2
Fosl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 8 99.98 Very High Very High Very High
Morphine 7 99.84 Very High Very High Very High
Analgesic 5 99.76 Very High Very High Very High
narcan 3 99.76 Very High Very High Very High
Spinal cord 9 99.52 Very High Very High Very High
Dorsal horn neuron 3 99.36 Very High Very High Very High
intrathecal 5 99.28 Very High Very High Very High
nociceptor 2 99.24 Very High Very High Very High
tetrodotoxin 2 98.84 Very High Very High Very High
medulla 10 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 6 100.00 Very High Very High Very High
Pruritus 4 96.60 Very High Very High Very High
Pain 5 96.24 Very High Very High Very High
Facial Pain 1 95.96 Very High Very High Very High
Neuropathic Pain 5 91.04 High High
Inflammatory Pain 1 87.88 High High
Nervous System Injury 1 80.00 Quite High
INFLAMMATION 1 32.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of the expression of Fos-like immunoreactivity by exogenous morphine speaks in favour of an opioidergic link in the modulation of orofacial pain in the trigeminal nuclei.
Negative_regulation (reduction) of Gene_expression (expression) of Fos-like associated with face pain and morphine
1) Confidence 0.54 Published 1995 Journal Brain Res. Section Abstract Doc Link 7614003 Disease Relevance 0.18 Pain Relevance 0.83
Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat.
Negative_regulation (inhibits) of Gene_expression (expression) of Fos-like in spinal cord associated with nociception, analgesic, gabapentin and spinal cord
2) Confidence 0.43 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10640314 Disease Relevance 0.42 Pain Relevance 1.08
Sevoflurane suppresses noxious stimulus-evoked expression of Fos-like immunoreactivity in the rat spinal cord via activation of endogenous opioid systems.
Negative_regulation (suppresses) of Gene_expression (expression) of Fos-like immunoreactivity in spinal cord associated with analgesic, endogenous opioid and spinal cord
3) Confidence 0.43 Published 2002 Journal Life Sci. Section Title Doc Link 12052441 Disease Relevance 0 Pain Relevance 0.87
We conclude that the peripheral noxious inputs (which ascend via the ventral half of the spinal cord in this study) can activate the supraspinal descending inhibitory systems, which in turn suppress the synthesis of Fos-like protein in the related dorsal horn neurons.
Negative_regulation (suppress) of Gene_expression (synthesis) of Fos-like protein in spinal cord associated with dorsal horn neuron and spinal cord
4) Confidence 0.39 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152541 Disease Relevance 0.06 Pain Relevance 0.21
Basal increase in c-Fos-like expression in superior colliculus of Royal College of Surgeons dystrophic rats can be abolished by intraocular injection of tetrodotoxin.
Negative_regulation (abolished) of Gene_expression (expression) of Fos-like in superior colliculus associated with tetrodotoxin
5) Confidence 0.38 Published 2001 Journal Neuroscience Section Title Doc Link 11744251 Disease Relevance 0 Pain Relevance 0.20
Expression of Fos-like immunoreactivity in these animals was markedly reduced by morphine pretreatment (10 mg/kg, i.p.), suggesting that the transmission of both itch and pain is blocked by morphine.
Negative_regulation (reduced) of Gene_expression (Expression) of Fos-like associated with pain, pruritus and morphine
6) Confidence 0.31 Published 1992 Journal Brain Res. Section Abstract Doc Link 1291036 Disease Relevance 0.49 Pain Relevance 0.55
In six male Wistar-Kyoto rats (WKY), unilateral injection of an antisense oligonucleotide to c-fos mRNA suppressed the expression of Fos-like immunoreactivity in neurons in the RVM in response to inhibition of depressor neurons in the caudal ventrolateral medulla (CVLM).
Negative_regulation (suppressed) of Gene_expression (expression) of Fos-like in medulla associated with medulla
7) Confidence 0.24 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8184987 Disease Relevance 0 Pain Relevance 0.43
Intrathecal and intravenous injection of ZJ-11 suppressed the expression of Fos-like immunoreactivity, induced by paw formalin injection, in laminae I-II in segments L4-L5 of the spinal cord, suggesting an action on sensory spinal transmission.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos-like in paw associated with spinal cord and intrathecal
8) Confidence 0.13 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15233757 Disease Relevance 0.49 Pain Relevance 0.88

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