INT5202

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2010
Negated 60
Speculated 42
Reported most in Abstract
Documents 1163
Total Number 1205
Disease Relevance 319.28
Pain Relevance 684.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 203
brain 182
neurons 163
spinal 145
nucleus 140
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2542 100.00 Very High Very High Very High
Pain 1934 100.00 Very High Very High Very High
Morphine 1738 100.00 Very High Very High Very High
antagonist 1339 100.00 Very High Very High Very High
Dorsal horn 1314 100.00 Very High Very High Very High
amygdala 1310 100.00 Very High Very High Very High
qutenza 1247 100.00 Very High Very High Very High
Inflammation 1204 100.00 Very High Very High Very High
withdrawal 998 100.00 Very High Very High Very High
agonist 778 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1694 100.00 Very High Very High Very High
Nociception 1237 100.00 Very High Very High Very High
INFLAMMATION 1095 100.00 Very High Very High Very High
Stress 832 100.00 Very High Very High Very High
Urological Neuroanatomy 795 100.00 Very High Very High Very High
Overactive Bladder 715 100.00 Very High Very High Very High
Hyperalgesia 575 100.00 Very High Very High Very High
Anxiety Disorder 406 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

128 100.00 Very High Very High Very High
Generalized Anxiety Disorder 86 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regional differences in naloxone modulation of Delta(9)-THC induced Fos expression in rat brain.
Positive_regulation (induced) of Gene_expression (expression) of Fos in brain associated with narcan
1) Confidence 0.70 Published 2003 Journal Neuropharmacology Section Title Doc Link 12623225 Disease Relevance 0.07 Pain Relevance 0.77
RESULTS: Acute fluoxetine increased the airjet-induced escape behaviour and Fos expression in the LC of saline-pretreated rats.
Positive_regulation (increased) of Gene_expression (expression) of Fos
2) Confidence 0.70 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 16521035 Disease Relevance 0 Pain Relevance 0
In addition, in the hypothalamic paraventricular nucleus (PVN), Fos expression was increased after naloxone-but not after naloxone methiodide-administration to morphine-dependent rats.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Fos in nucleus associated with narcan and morphine
3) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15033383 Disease Relevance 0.06 Pain Relevance 1.43
Expression of the transcription factor Fos is known to increase during opiate withdrawal, but its presence during low-dose antagonist-precipitated withdrawal has not previously been established.
Positive_regulation (increase) of Gene_expression (Expression) of Fos associated with antagonist, opiate and withdrawal
4) Confidence 0.70 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11120397 Disease Relevance 0 Pain Relevance 1.20
These authors showed that noxious stimulation (application of radiant heat or mustard oil) to the hind paw resulted in a massive increase in the expression of Fos in neurons in the dorsal horn of the lumbar spinal cord.
Positive_regulation (increase) of Gene_expression (expression) of Fos in neurons associated with dorsal horn and spinal cord
5) Confidence 0.70 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434195 Disease Relevance 0.45 Pain Relevance 0.38
BACKGROUND: It has been proposed that the measure of noxious stimulus-induced Fos (the protein product of the immediate early gene c-fos) expression in the spinal cord dorsal horn of laboratory animals may provide an estimate of the potential of specific treatments to produce preemptive analgesia.
Positive_regulation (induced) of Gene_expression (expression) of Fos in spinal cord dorsal horn associated with dorsal horn, preemptive analgesia and spinal cord
6) Confidence 0.70 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9447868 Disease Relevance 0.07 Pain Relevance 0.53
This study provides evidence of spatial and temporal changes in Fos expression induced by plantar incision.
Positive_regulation (induced) of Gene_expression (expression) of Fos
7) Confidence 0.70 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.14 Pain Relevance 1.34
A selective increase in Fos expression in spinal dorsal horn neurons following graded thermal stimulation in rats with experimental mononeuropathy.
Positive_regulation (increase) of Gene_expression (expression) of Fos in spinal associated with dorsal horn neuron and diabetic nephropathy
8) Confidence 0.70 Published 2001 Journal Pain Section Title Doc Link 11207401 Disease Relevance 0.66 Pain Relevance 0.37
Capsaicin- or formalin-induced Fos expression was reduced in both cases by pretreatment of capsazepine, but to a much lesser extent for formalin.
Positive_regulation (induced) of Gene_expression (expression) of Fos associated with qutenza
9) Confidence 0.70 Published 1998 Journal Neuroscience Section Abstract Doc Link 9881874 Disease Relevance 0.80 Pain Relevance 1.32
We showed recently that conditioned fear to context induces Fos expression in the ventrolateral periaqueductal gray [Neuroscience (1997) 78, 165-177].
Positive_regulation (induces) of Gene_expression (expression) of Fos associated with anxiety disorder and central grey
10) Confidence 0.70 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682714 Disease Relevance 0.54 Pain Relevance 0.37
The results show that, when lidocaine was microinjected in the medial part of the central nucleus of the amygdala or along the ventral amygdalofugal pathway of conditioned rats, fear-induced Fos expression in the ventrolateral periaqueductal gray was reduced on the side ipsilateral to the injection (up to 37% reduction in comparison to the contralateral side).
Positive_regulation (-) of Gene_expression (expression) of Fos in nucleus associated with anxiety disorder, central grey, amygdala and lidocaine
11) Confidence 0.70 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682714 Disease Relevance 0.77 Pain Relevance 0.87
The aims of this study were: to map, in conscious rats, central pathways activated by AA using Fos as a marker of neuronal activation; to characterize primary afferent fibres involved in this activation; and to investigate the effect of fedotozine on AA-induced Fos expression.
Positive_regulation (induced) of Gene_expression (expression) of Fos in neuronal associated with primary afferent fibers
12) Confidence 0.70 Published 2000 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10771495 Disease Relevance 0.15 Pain Relevance 0.57
Fedotozine, a kappa-opioid agonist, prevents spinal and supra-spinal Fos expression induced by a noxious visceral stimulus in the rat.
Positive_regulation (induced) of Gene_expression (expression) of Fos in spinal associated with mu agonist and qutenza
13) Confidence 0.70 Published 2000 Journal Neurogastroenterol. Motil. Section Title Doc Link 10771495 Disease Relevance 0.16 Pain Relevance 0.83
Trigeminal nociception-induced cerebral Fos expression in the conscious rat.
Positive_regulation (induced) of Gene_expression (expression) of Fos associated with nociception and qutenza
14) Confidence 0.70 Published 2001 Journal Cephalalgia Section Title Doc Link 11843868 Disease Relevance 0.61 Pain Relevance 0.96
Many of these areas participate in (anti)-nociception, although we cannot exclude the possibility that in conscious animals the pain-associated physiological and behavioural responses that are an intrinsic and necessary part of coping with pain have generated the increased Fos expression.
Positive_regulation (increased) of Gene_expression (expression) of Fos associated with nociception and pain
15) Confidence 0.70 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11843868 Disease Relevance 0.56 Pain Relevance 1.06
In addition, the ventrolateral periaqueductal grey, the intralaminar thalamic and various hypothalamic areas, showed an enhanced Fos expression after the intracisternal administration of capsaicin.
Positive_regulation (enhanced) of Gene_expression (expression) of Fos associated with qutenza and periaqueductal grey
16) Confidence 0.70 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11843868 Disease Relevance 0.73 Pain Relevance 1.08
The 2G hypergravity remarkably induced Fos expression in the paraventricular and arcuate nuclei of the hypothalamus.
Positive_regulation (induced) of Gene_expression (expression) of Fos in hypothalamus
17) Confidence 0.70 Published 2002 Journal Adv Space Res Section Abstract Doc Link 12530366 Disease Relevance 0.39 Pain Relevance 0.42
Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray.
Positive_regulation (increased) of Gene_expression (expression) of Fos in midbrain associated with anxiety disorder, midbrain and central grey
18) Confidence 0.70 Published 1997 Journal Neuroscience Section Title Doc Link 9135098 Disease Relevance 0.73 Pain Relevance 0.21
It was associated with an overall increase in Fos expression in the entire periaqueductal gray that was significantly greater than in the two other groups.
Positive_regulation (increase) of Gene_expression (expression) of Fos associated with central grey
19) Confidence 0.70 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135098 Disease Relevance 0.82 Pain Relevance 0.23
Increases in neural activation after drug-paired environmental exposure were dependent on exposure to the specifically paired environment; exposure to an alternative environment in morphine-treated rats did not elicit similar increases in Fos expression.
Neg (not) Positive_regulation (increases) of Gene_expression (expression) of Fos in neural associated with morphine
20) Confidence 0.70 Published 2002 Journal Behav. Neurosci. Section Abstract Doc Link 12148940 Disease Relevance 0.07 Pain Relevance 0.26

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