INT52020

Context Info Confidence 0.31 First Reported 1995 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.56 Pain Relevance 5.71

cytosol (ICA1) Golgi apparatus (ICA1) nucleolus (ICA1) nucleus (ICA1) molecular_function (ICA1) cytoplasm (ICA1)

Anatomy Link Frequency neurons 1 chromaffin cells 1 ICA1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 33 99.98 tetrodotoxin 25 99.96 Calcium channel 6 99.40 Trigeminal ganglion neurons 9 99.04 Pain 3 91.16 Analgesic 6 90.28 Action potential 5 90.00 sodium channel 3 75.00 headache 1 25.00

Disease Link Frequency Relevance Heat Syndrome 4 99.56 Ganglion Cysts 9 98.60 Small Cell Lung Cancer 8 96.76 Pain 3 91.16 Lung Cancer 2 75.00 Cancer 1 38.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Capsaicin inhibited ICa in capsaicin-sensitive trigeminal ganglion neurons, but not in capsaicin-insensitive neurons.

Negative_regulation (inhibited) of ICa in neurons associated with ganglion cysts, qutenza and trigeminal ganglion neurons

1) Confidence 0.31 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407761 Disease Relevance 0.29 Pain Relevance 1.11

Capsaicin inhibited ICa in transient receptor potential vanilloid-1-expressing C2D7 cells stably expressing human N-type calcium channels, whereas capsaicin failed to inhibit ICa in naïve C2D7 cells with no endogenous transient receptor potential vanilloid-1 expression.

Negative_regulation (inhibited) of ICa associated with qutenza and calcium channel

2) Confidence 0.31 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407761 Disease Relevance 0.26 Pain Relevance 1.30

Capsaicin inhibited ICa in transient receptor potential vanilloid-1-expressing C2D7 cells stably expressing human N-type calcium channels, whereas capsaicin failed to inhibit ICa in naïve C2D7 cells with no endogenous transient receptor potential vanilloid-1 expression.

Negative_regulation (inhibit) of ICa associated with qutenza and calcium channel

3) Confidence 0.31 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407761 Disease Relevance 0.24 Pain Relevance 1.29

BACKGROUND: Bilateral ICA absence is a rare lesion.

Negative_regulation (absence) of ICA

4) Confidence 0.31 Published 2006 Journal Surg Neurol Section Abstract Doc Link 16720187 Disease Relevance 0 Pain Relevance 0

We found that both time to peak and time-constant of inactivation of ICa,TTX were slower than that of INa.

Negative_regulation (inactivation) of ICa associated with tetrodotoxin

5) Confidence 0.21 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8581402 Disease Relevance 0 Pain Relevance 0.87

ICa,TTX was insensitive to 250 microM Ni2+ and 10 microM La3+, both known to block totally T-type ICa (not evidenced here).

Negative_regulation (block) of ICa associated with tetrodotoxin

6) Confidence 0.21 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8581402 Disease Relevance 0 Pain Relevance 0.87

The autoantibodies implicated in the Lambert-Eaton myasthenic syndrome (LES), which are known to inhibit ICa and INa in bovine adrenal chromaffin cells, also significantly inhibited INa in SCLC cells.

Negative_regulation (inhibit) of ICa in chromaffin cells associated with syndrome and small cell lung cancer

7) Confidence 0.04 Published 1995 Journal J. Membr. Biol. Section Abstract Doc Link 7731034 Disease Relevance 0.77 Pain Relevance 0.27

General Comments

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