INT52020

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Context Info
Confidence 0.31
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.56
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ICA1) Golgi apparatus (ICA1) nucleolus (ICA1)
nucleus (ICA1) molecular_function (ICA1) cytoplasm (ICA1)
Anatomy Link Frequency
neurons 1
chromaffin cells 1
ICA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 33 99.98 Very High Very High Very High
tetrodotoxin 25 99.96 Very High Very High Very High
Calcium channel 6 99.40 Very High Very High Very High
Trigeminal ganglion neurons 9 99.04 Very High Very High Very High
Pain 3 91.16 High High
Analgesic 6 90.28 High High
Action potential 5 90.00 High High
sodium channel 3 75.00 Quite High
headache 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Syndrome 4 99.56 Very High Very High Very High
Ganglion Cysts 9 98.60 Very High Very High Very High
Small Cell Lung Cancer 8 96.76 Very High Very High Very High
Pain 3 91.16 High High
Lung Cancer 2 75.00 Quite High
Cancer 1 38.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin inhibited ICa in capsaicin-sensitive trigeminal ganglion neurons, but not in capsaicin-insensitive neurons.
Negative_regulation (inhibited) of ICa in neurons associated with ganglion cysts, qutenza and trigeminal ganglion neurons
1) Confidence 0.31 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407761 Disease Relevance 0.29 Pain Relevance 1.11
Capsaicin inhibited ICa in transient receptor potential vanilloid-1-expressing C2D7 cells stably expressing human N-type calcium channels, whereas capsaicin failed to inhibit ICa in naïve C2D7 cells with no endogenous transient receptor potential vanilloid-1 expression.
Negative_regulation (inhibited) of ICa associated with qutenza and calcium channel
2) Confidence 0.31 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407761 Disease Relevance 0.26 Pain Relevance 1.30
Capsaicin inhibited ICa in transient receptor potential vanilloid-1-expressing C2D7 cells stably expressing human N-type calcium channels, whereas capsaicin failed to inhibit ICa in naïve C2D7 cells with no endogenous transient receptor potential vanilloid-1 expression.
Negative_regulation (inhibit) of ICa associated with qutenza and calcium channel
3) Confidence 0.31 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407761 Disease Relevance 0.24 Pain Relevance 1.29
BACKGROUND: Bilateral ICA absence is a rare lesion.
Negative_regulation (absence) of ICA
4) Confidence 0.31 Published 2006 Journal Surg Neurol Section Abstract Doc Link 16720187 Disease Relevance 0 Pain Relevance 0
We found that both time to peak and time-constant of inactivation of ICa,TTX were slower than that of INa.
Negative_regulation (inactivation) of ICa associated with tetrodotoxin
5) Confidence 0.21 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8581402 Disease Relevance 0 Pain Relevance 0.87
ICa,TTX was insensitive to 250 microM Ni2+ and 10 microM La3+, both known to block totally T-type ICa (not evidenced here).
Negative_regulation (block) of ICa associated with tetrodotoxin
6) Confidence 0.21 Published 1995 Journal Recept. Channels Section Abstract Doc Link 8581402 Disease Relevance 0 Pain Relevance 0.87
The autoantibodies implicated in the Lambert-Eaton myasthenic syndrome (LES), which are known to inhibit ICa and INa in bovine adrenal chromaffin cells, also significantly inhibited INa in SCLC cells.
Negative_regulation (inhibit) of ICa in chromaffin cells associated with syndrome and small cell lung cancer
7) Confidence 0.04 Published 1995 Journal J. Membr. Biol. Section Abstract Doc Link 7731034 Disease Relevance 0.77 Pain Relevance 0.27

General Comments

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