INT52021

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Context Info
Confidence 0.39
First Reported 1995
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 22.43
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma 1
juvenile 1
B cells 1
CSF 1
arm 1
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 19 98.68 Very High Very High Very High
Pain 36 98.24 Very High Very High Very High
abdominal pain 3 98.02 Very High Very High Very High
sodium channel 3 97.84 Very High Very High Very High
Morphine 60 97.60 Very High Very High Very High
substance P 3 97.32 Very High Very High Very High
rheumatoid arthritis 20 97.08 Very High Very High Very High
opioid receptor 3 96.04 Very High Very High Very High
Action potential 5 93.84 High High
Demyelination 7 83.64 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 94 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 6 99.84 Very High Very High Very High
Immunization 229 99.60 Very High Very High Very High
Small Cell Lung Cancer 8 99.36 Very High Very High Very High
Infection 269 99.24 Very High Very High Very High
Syndrome 64 99.06 Very High Very High Very High
Demyelinating Disease 34 98.68 Very High Very High Very High
Eosinophilia 4 98.60 Very High Very High Very High
Malaria 232 98.56 Very High Very High Very High
Aging 70 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detailed statistical analyses allowing for sex and age group showed that infection intensity did not have a significant effect on anti-Sh13 IgG3 levels (F = 0.329, df = 1, 147, p = 0.567).
Regulation (effect) of IgG3 associated with infection
1) Confidence 0.39 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523344 Disease Relevance 0.94 Pain Relevance 0
These observations suggest that important relationships exist between local IL-6 and IgA2, IgM, and IgG3 responses in human small intestinal luminal secretions.
Regulation (responses) of IgG3
2) Confidence 0.25 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.21 Pain Relevance 0.10
Twenty sera from patients with suspected enteric infection with A. caninum (manifested as eosinophilic enteritis or unexplained abdominal pain with peripheral eosinophilia) were tested; 16 had total IgG antibodies to Ac68, while IgG1, IgG2, IgG3, and IgG4 responses were found in 11, 10, 9, and 12 of these sera, respectively.
Regulation (responses) of IgG4 associated with rhinitis, abdominal pain, enteritis, eosinophilia and infection
3) Confidence 0.25 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.98 Pain Relevance 0.10
Twenty sera from patients with suspected enteric infection with A. caninum (manifested as eosinophilic enteritis or unexplained abdominal pain with peripheral eosinophilia) were tested; 16 had total IgG antibodies to Ac68, while IgG1, IgG2, IgG3, and IgG4 responses were found in 11, 10, 9, and 12 of these sera, respectively.
Regulation (responses) of IgG3 associated with rhinitis, abdominal pain, enteritis, eosinophilia and infection
4) Confidence 0.25 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.98 Pain Relevance 0.10
For this analysis, IgG1 to IgG4 values were log-transformed or dichotomised as indicated in the ELISA section.
Regulation (values) of IgG4
5) Confidence 0.22 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.33 Pain Relevance 0
No changes in IgG2 and IgG4 responses were evident in the control arm.
Regulation (responses) of IgG4 in arm
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0.08 Pain Relevance 0
The immunogenicity of MSP3-LSP was demonstrated by the higher IgG responses observed in both dose groups compared both to baseline levels and to the levels in the group given the comparator vaccine.
Regulation (responses) of IgG
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0.20 Pain Relevance 0
This study was conducted to shed light on the overall specific IgG antibody response as well as the specific IgG antibody subclass responses in cerebrospinal fluid (CSF) of patients with EOM.
Regulation (responses) of IgG in CSF associated with meningitis
8) Confidence 0.09 Published 2007 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 17539242 Disease Relevance 1.43 Pain Relevance 0.10
Depending on the individual, IgG reactivity was directed against NP, VP40, VP35 VP24 and/or sGP (Figure 4).
Regulation (directed) of IgG
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817732 Disease Relevance 0 Pain Relevance 0
As observed with total IgG responses, the MM group showed higher prevalence of IgG1 responses to eight antigens and IgG3 responses to for five antigens compared to HC.
Regulation (responses) of IgG3 associated with malaria
10) Confidence 0.06 Published 2008 Journal Malar J Section Body Doc Link PMC2491629 Disease Relevance 0.83 Pain Relevance 0
While mixed IgG1/IgG3 responses to all MSP antigens used was detected, the relative proportions of these two subclasses were different for the different MSP antigens, implying that IgG class switching may be greatly influenced by the characteristics of the antigen as previously suggested [40,51,62].
Regulation (responses) of IgG3
11) Confidence 0.06 Published 2008 Journal Malar J Section Body Doc Link PMC2491629 Disease Relevance 0 Pain Relevance 0
HHV-6 A- or B-specific P41 antigens do not reveal virus variant-specific IgG or IgM responses in human serum.
Regulation (responses) of IgG
12) Confidence 0.05 Published 2002 Journal J. Med. Virol. Section Title Doc Link 11793393 Disease Relevance 0.63 Pain Relevance 0.24
There were no changes in IgG or AcRh measurements.
Neg (no) Regulation (changes) of IgG
13) Confidence 0.05 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10430743 Disease Relevance 0.35 Pain Relevance 0.32
BAL IgG and IgA response to injected and inhaled 23-PPV
Regulation (response) of IgG
14) Confidence 0.03 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0 Pain Relevance 0
His serology was negative for IgG anti-GQ1b and anti-GM1 ganglioside and related antibodies.
Regulation (negative) of IgG
15) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923178 Disease Relevance 0.57 Pain Relevance 0.03
However, the sensitivity of elevated serum IgG4 levels is 63%–68% in other reports.15,16,49 Elevation of serum IgG4 levels has been reported in a patient with pancreatic cancer.50

Radiological findings

Regulation (sensitivity) of IgG4 associated with pancreatic cancer
16) Confidence 0.02 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.19 Pain Relevance 0.03
Probably the most important difference was an early IgG response to CHIKV, compared with a clear delay of IgG (appearing after IgM) in most acute cases of primary dengue virus infection.
Regulation (response) of IgG associated with dengue and infection
17) Confidence 0.02 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2570846 Disease Relevance 0.86 Pain Relevance 0
The concentrations of the serum immunoglobulins, IgG, IgA, and IgM, were previously determined in 200 patients with juvenile rheumatoid arthritis, which showed abnormality in the distribution of these immunoglobulins in JIA10).
Regulation (concentrations) of IgG in juvenile associated with rheumatoid arthritis
18) Confidence 0.01 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012272 Disease Relevance 1.80 Pain Relevance 0.34
These results indicate that (i) action potentials in human SCLC cells result from the regenerative increase in voltage-gated Na+ channel conductance; (ii) fundamental characteristics of SCLC Na+ channels are the same as the classical sodium channels found in a variety of excitable cells; and (iii) in some LES patients, SCLC Na+ channels are an additional target of the pathological IgG present in the patients' sera.
Regulation (target) of IgG associated with action potential, syndrome, sodium channel and small cell lung cancer
19) Confidence 0.01 Published 1995 Journal J. Membr. Biol. Section Abstract Doc Link 7731034 Disease Relevance 0.91 Pain Relevance 0.17
Immunologic analysis showed rapid decrease in peripheral B cells but no change in IgG levels.
Neg (no) Regulation (change) of IgG in B cells
20) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779377 Disease Relevance 1.03 Pain Relevance 0.04

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