INT5204

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 60
Total Number 60
Disease Relevance 23.54
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
EPI 8
SH-SY5Y 2
22RV1 2
testes 2
lens 2
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 1 99.84 Very High Very High Very High
endometriosis 4 99.32 Very High Very High Very High
Central grey 93 98.72 Very High Very High Very High
Rostral ventromedial medulla 51 98.40 Very High Very High Very High
diabetic neuropathy 7 98.20 Very High Very High Very High
antagonist 175 97.60 Very High Very High Very High
Catecholamine 51 95.56 Very High Very High Very High
fibrosis 5 95.44 Very High Very High Very High
Kinase C 7 91.92 High High
withdrawal 123 90.56 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 190 100.00 Very High Very High Very High
Dysmenorrhea 1 99.84 Very High Very High Very High
Cancer 1201 99.78 Very High Very High Very High
Prostate Cancer 735 99.76 Very High Very High Very High
Targeted Disruption 56 99.60 Very High Very High Very High
Endometriosis (extended) 15 99.32 Very High Very High Very High
Disease 146 99.00 Very High Very High Very High
Urological Neuroanatomy 95 98.72 Very High Very High Very High
Endometrial Cancer 1 98.60 Very High Very High Very High
Cataract 95 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This raises the possibility of increasing androgen receptor expression may alter the prostate cancer cells' response to its ligand or even its antagonists.
Positive_regulation (increasing) of Gene_expression (expression) of androgen receptor associated with antagonist and prostate cancer
1) Confidence 0.67 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.57 Pain Relevance 0.12
Rescue experiments are inadequate here, because even a modest increase in AR expression modifies the phenotype of the prostate tumor cells [6].
Positive_regulation (increase) of Gene_expression (expression) of AR associated with prostate cancer
2) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.84 Pain Relevance 0.03
We then transfected AR-siRNA into C4-2 and 22RV1 cells and compared the kinetics of the AR protein level, the cells' proliferation, quantified by the MTT activity, and apoptosis, measured with a caspases assay were affected.
Positive_regulation (transfected) of Gene_expression (transfected) of AR-siRNA in 22RV1 associated with apoptosis
3) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.56 Pain Relevance 0
In patients, AR overexpression can result from gene amplification, increased transcription, or stabilization of the AR protein [7], recently linked to the phosphorylation of some AR residues [8], [9].
Positive_regulation (overexpression) of Gene_expression (overexpression) of AR
4) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.75 Pain Relevance 0.15
In experimental tumors, a moderate overexpression of AR in androgen-dependent tumors allows experimental tumors bypassing hormone ablation [6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of AR associated with cancer
5) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.78 Pain Relevance 0.14
Consistent with the presence of this “promiscuous” AR, the growth of PC346Flu2, as well as expression of AR target genes, are stimulated by both the synthetic androgen R1881 and the antiandrogen hydroxyflutamide (unpublished data) [20].
Positive_regulation (stimulated) of Gene_expression (expression) of AR
6) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0.04
Moreover, the AR gene is amplified and/or overexpressed in about 30% of the hormone-therapy refractory tumors, and it has been proposed this could sensitize the receptor for the residual androgen concentrations and antiandrogens present under hormonal therapies [6], [7], [8].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of AR associated with cancer
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.99 Pain Relevance 0.06
Increased AR expression was necessary and sufficient to convert androgen-sensitive PCa to an ablation-resistant state [9].
Positive_regulation (Increased) of Gene_expression (expression) of AR associated with prostate cancer
8) Confidence 0.51 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 1.49 Pain Relevance 0
The expression of the androgen receptor was also detected in adenomyosis, endometriosis and endometrial carcinoma.
Positive_regulation (detected) of Gene_expression (expression) of androgen receptor associated with endometriosis, dismenorea and endometrial cancer
9) Confidence 0.50 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1291578 Disease Relevance 0.54 Pain Relevance 0.15
This "bipolar androgen therapy" will not allow time for prostate cancer cells to adapt their AR expression in response to environmental conditions.
Positive_regulation (response) of Gene_expression (expression) of AR associated with reprotox - general 1
10) Confidence 0.50 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.29 Pain Relevance 0
The wild type androgen receptor is unresponsive or only weakly activated by antiandrogens.
Positive_regulation (activated) of Gene_expression (unresponsive) of wild type androgen receptor
11) Confidence 0.49 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.72 Pain Relevance 0.07
Our results demonstrate that androgen dependent, but also and more importantly, exponentially growing and vascularized castration-resistant prostate tumors, are still dependent on the expression of a functional AR for their growth and angiogenesis.
Positive_regulation (dependent) of Gene_expression (expression) of AR associated with prostate cancer
12) Confidence 0.47 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.52 Pain Relevance 0.05
This response may be due to effects of high-dose androgen on inhibiting re-licensing of DNA in cells expressing high levels of AR.
Positive_regulation (levels) of Gene_expression (expressing) of AR
13) Confidence 0.47 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.41 Pain Relevance 0.07
Another mechanism could be over-expression of androgen receptor.
Positive_regulation (over) of Gene_expression (over) of androgen receptor
14) Confidence 0.45 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.53 Pain Relevance 0.08
Another mechanism could be over-expression of androgen receptor.
Positive_regulation (over) of Gene_expression (expression) of androgen receptor
15) Confidence 0.45 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.53 Pain Relevance 0.08
Interestingly, the sequence specificity of siRNA allowed here discriminating in vivo the closely related mouse and human AR mRNAs: treatment with hAR-siRNA silenced AR in tumor cells and inhibited the tumor growth while preserving AR expression in mouse prostate and testes.
Positive_regulation (preserving) of Gene_expression (expression) of AR in testes associated with cancer
16) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.90 Pain Relevance 0.05
Transfection of AR-siRNA in LNCaP cells strongly inhibits the androgen-induced transcription of Prostate Specific Antigen (PSA), a prototypic AR-target gene (Figure 1B).
Positive_regulation (Transfection) of Gene_expression (Transfection) of AR-siRNA
17) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.67 Pain Relevance 0.04
In conclusion, the present study shows that AR overexpression (in PC346Flu1) and mutation (in PC346Flu2) may allow for the maintenance of the AR activity under androgen ablation and antiandrogen treatment.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AR
18) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.14 Pain Relevance 0.05
In addition to being potential mitogens, mounting evidence indicates that these growth hormones are also able to cross-talk with the AR signaling pathway, leading to expression of AR target genes in the absence of androgens [17].
Positive_regulation (leading) of Gene_expression (expression) of AR
19) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.96 Pain Relevance 0
Increased AR expression was necessary and sufficient to convert androgen-sensitive PCa to an ablation-resistant state [9].
Positive_regulation (necessary) of Gene_expression (expression) of AR associated with prostate cancer
20) Confidence 0.34 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 1.49 Pain Relevance 0

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