INT52047

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 34.75
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
macrophages 3
astrocytes 3
plasma 2
epithelium 2
liver 1
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 261 99.90 Very High Very High Very High
Bioavailability 5 98.36 Very High Very High Very High
Multiple sclerosis 69 97.84 Very High Very High Very High
Calcium channel 6 93.24 High High
Inflammatory response 79 92.80 High High
chemokine 25 92.08 High High
tetrodotoxin 2 90.52 High High
Action potential 3 89.80 High High
imagery 126 88.04 High High
cytokine 179 84.32 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 283 100.00 Very High Very High Very High
Stroke 138 100.00 Very High Very High Very High
Dementia 268 99.92 Very High Very High Very High
Heart Disease 42 99.92 Very High Very High Very High
Depression 329 99.90 Very High Very High Very High
Obesity 345 99.84 Very High Very High Very High
Cardiovascular Disease 187 99.80 Very High Very High Very High
Sprains And Strains 14 99.74 Very High Very High Very High
Cognitive Disorder 444 99.30 Very High Very High Very High
Atherosclerosis 204 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of ApoE in astrocytes is controlled by several receptor/effector systems such as adrenoceptors and cAMP.
Gene_expression (production) of ApoE in astrocytes
1) Confidence 0.78 Published 2001 Journal Biochem. Soc. Symp. Section Abstract Doc Link 11447828 Disease Relevance 0.36 Pain Relevance 0.22
In the presence of beta A4-peptide fragments, astrocytes stop their synthesis of ApoE resulting in a massive reduction in the bioavailability of ApoE.
Gene_expression (synthesis) of ApoE in astrocytes associated with bioavailability
2) Confidence 0.78 Published 2001 Journal Biochem. Soc. Symp. Section Abstract Doc Link 11447828 Disease Relevance 0.34 Pain Relevance 0.22
than apoE3-expressing, apoE4-expressing, or apoE-deficient macrophages (Zhao et al., 2009).
Gene_expression (expressing) of apoE in macrophages
3) Confidence 0.75 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.29 Pain Relevance 0.21
When a region of NCoA6(NRC) containing LxxLL-AD2 was expressed in mammalian cells, it was found to be only moderately active when expressed alone.
Gene_expression (expressed) of AD2
4) Confidence 0.75 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
ApoA-I increases apoE secretion with minimal effect upon apoE gene expression
Gene_expression (expression) of apoE gene
5) Confidence 0.74 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.37 Pain Relevance 0
In addition, Bernier et al, in collaboration with our laboratory, has demonstrated that overexpression of apoE in adipocytes reduces differentiation as well as the accumulation of cholesterol and triglycerides in these cells [7].
Gene_expression (overexpression) of apoE in adipocytes associated with obesity
6) Confidence 0.74 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.60 Pain Relevance 0
Finally, our subjects were phenotypically well characterized, enabling us to discount history of CVD and risk factors for CVD as possible explanations for the relation between APOE genotype and hsCRP.
Gene_expression (genotype) of APOE associated with cardiovascular disease
7) Confidence 0.68 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.72 Pain Relevance 0
Clarification of the association between APOE genotype and CRP is important for at least two reasons.
Gene_expression (genotype) of APOE
8) Confidence 0.68 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.73 Pain Relevance 0.09
First, the biologic mechanisms responsible for the association between APOE genotype and CVD remain unclear; examining whether associations between APOE and potential cardiovascular risk factors (such as CRP) mirror the association of APOE with CVD is, therefore, helpful in elucidating the causal pathway.
Gene_expression (genotype) of APOE associated with cardiovascular disease
9) Confidence 0.68 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.70 Pain Relevance 0.09
Subgroup analysis, stratifying by gender and by APOE4 status, revealed various other associations before correction: HLA-B27 in APOE4 negatives (odds ratio = 2.95, 95% confidence interval = 1.1–7.9, p = 0.035); HLA-Cw1 in APOE4 negatives (3.4, 1.2–9.6, 0.03) and in men (11.3, 1.4–89, 0.004); HLA-Cw15 in APOE4 positives (0.11, 0.01–0.99, 0.03) and in men (0.11, 0.01–0.9, 0.02).
Neg (negatives) Gene_expression (negatives) of APOE4
10) Confidence 0.66 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.08 Pain Relevance 0
Although the odds ratios were higher in APOE4 negatives than in positives and were only significant in the former, the differences were not significant.
Neg (negatives) Gene_expression (negatives) of APOE4
11) Confidence 0.66 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.24 Pain Relevance 0
Next, oligonucleotides containing the sequence for the ApoE ligand (LRKLRKRLLRDWLKAFYDKVAEKLKEAF) (synthesized by Integrated DNA Technologies; Coralville, Iowa, USA), flanked by AscI and PacI sites, were annealed, cut with AscI and PacI, and inserted into the corresponding sites of pAAVRCKI to make pAAV2apoE.
Gene_expression (synthesized) of ApoE
12) Confidence 0.65 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0 Pain Relevance 0
LexA-NRC (NRC containing AD1 and AD2 activation domains) when expressed in yeast was not found to be constitutively active, however, 100 fold activation was detected when RXR without any heterologous activation domain was co-expressed in the presence of its ligand.
Gene_expression (containing) of AD2
13) Confidence 0.65 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
In animal models and in humans it has been observed that diets rich in these substances or containing a supplement of them (omega-3 fatty acids, docosahexaenoic acid) reduce AD risk, especially in individuals who do not carry the Apo E ?
Neg (not) Gene_expression (carry) of Apo E associated with disease
14) Confidence 0.65 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.43 Pain Relevance 0.11
There are virtually no loci, with the possible exception of APOE (Burwick et al., 2006), where published studies have been adequately powered to confidently exclude the possibility of a meaningful effect.
Neg (exception) Spec (possible) Gene_expression (exception) of APOE
15) Confidence 0.65 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.16 Pain Relevance 0.05
Four risk factors for AD are firmly established: increasing age, the presence of the apolipoproteinE-epsilon4 allele, familial aggregation of cases, and Down's syndrome.
Gene_expression (presence) of apolipoproteinE associated with syndrome and disease
16) Confidence 0.65 Published 2001 Journal Aging (Milano) Section Abstract Doc Link 11442298 Disease Relevance 1.04 Pain Relevance 0.04
All these Paco(2)-corrected effects were reversed in the presence of the ApoE4 polymorphism.
Gene_expression (presence) of ApoE
17) Confidence 0.65 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17578972 Disease Relevance 0 Pain Relevance 0
Recent data suggest a genetic predisposition for cognitive decline after cardiac surgery in patients possessing the apolipoprotein E epsilon-4 allele, known to be associated with late-onset and sporadic forms of Alzheimer's disease.
Gene_expression (possessing) of apolipoprotein E associated with cognitive disorder, genetic predisposition to disease, disease and disorder of lipid metabolism
18) Confidence 0.65 Published 1995 Journal Ann. Thorac. Surg. Section Abstract Doc Link 7733762 Disease Relevance 0.82 Pain Relevance 0.12
than apoE3-expressing, apoE4-expressing, or apoE-deficient macrophages (Zhao et al., 2009).
Gene_expression (expressing) of apoE in macrophages
19) Confidence 0.65 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.29 Pain Relevance 0.21
However, other studies did not observe an association between level of depression and presence of the ApoE ?
Gene_expression (presence) of ApoE associated with depression
20) Confidence 0.65 Published 2003 Journal Ann Gen Hosp Psychiatry Section Body Doc Link PMC317342 Disease Relevance 1.27 Pain Relevance 0.39

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