INT5205

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 43
Total Number 46
Disease Relevance 12.87
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
nucleus 5
endometrium 2
kidney 2
tubes 1
Mouse 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 156 100.00 Very High Very High Very High
sSRI 34 99.48 Very High Very High Very High
fibrosis 9 97.74 Very High Very High Very High
adenocard 214 97.04 Very High Very High Very High
agonist 428 96.88 Very High Very High Very High
Central grey 93 95.92 Very High Very High Very High
antagonist 116 95.52 Very High Very High Very High
Rostral ventromedial medulla 51 95.36 Very High Very High Very High
antidepressant 94 95.28 Very High Very High Very High
Nortriptyline 22 94.60 High High
Disease Link Frequency Relevance Heat
Cancer 285 100.00 Very High Very High Very High
Stress 23 100.00 Very High Very High Very High
Adverse Drug Reaction 12 100.00 Very High Very High Very High
Prostate Cancer 356 99.92 Very High Very High Very High
Obesity 35 99.64 Very High Very High Very High
Shock 3 99.56 Very High Very High Very High
Disease 81 99.52 Very High Very High Very High
Reprotox - General 1 93 98.80 Very High Very High Very High
Cystic Fibrosis 9 97.74 Very High Very High Very High
Endometriosis (extended) 23 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical localization of androgen receptor in the human endometrium, decidua, placenta and pathological conditions of the endometrium.
Localization (localization) of androgen receptor in endometrium
1) Confidence 0.80 Published 1992 Journal Hum. Reprod. Section Title Doc Link 1291578 Disease Relevance 0.38 Pain Relevance 0.08
The immunohistochemical localization of the androgen receptor in the human endometrium at various stages of the menstrual cycle and post-menopausal period, in decidua and placenta of early pregnancy, and in several pathological conditions of the endometrium has been investigated.
Spec (investigated) Localization (localization) of androgen receptor in endometrium associated with endometriosis (extended)
2) Confidence 0.80 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1291578 Disease Relevance 0.15 Pain Relevance 0
Collocation of androgen receptor gene mutations in prostate cancer.
Localization (Collocation) of androgen receptor associated with prostate cancer
3) Confidence 0.74 Published 2001 Journal Clin. Cancer Res. Section Title Doc Link 11350894 Disease Relevance 0.38 Pain Relevance 0.11
The IL-1 stimulation of mitogen-activated protein/ERK kinase kinases (MEKK) results in phosphorylation of TAB2, an AR-interacting protein, which resulted in and release of the TAB2/N-CoR holocorepressor complex from the androgen receptor.
Localization (release) of androgen receptor
4) Confidence 0.68 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.36 Pain Relevance 0.24
C4-2B human PCa cells were stimulated by androgens for 4 hours and ChIP was performed with either AR or IgG control antibodies.
Localization (performed) of AR associated with prostate cancer
5) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.67 Pain Relevance 0
Clinical relevance of novel AR target genes
Localization (relevance) of AR
6) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.69 Pain Relevance 0
AR mRNA was studied in females implanted for 12 h, 2 and 16 days (separate experiments) with control and high dose tubes and in males castrated as above and implanted for 10 days with control tubes and high doses of KA or E2.


Localization (implanted) of AR mRNA in tubes
7) Confidence 0.49 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0 Pain Relevance 0.09
Furthermore, AR was cloned from stickleback kidney RNA and the molecular structures of two splicing variants, AR?
Localization (cloned) of AR in kidney
8) Confidence 0.49 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.11 Pain Relevance 0.08
All data from semi-quantitative analyses of mRNA are shown as AR in relation to 18S expression and presented as mean ± SD.
Localization (relation) of AR
9) Confidence 0.49 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0 Pain Relevance 0.03
The AvaII fragment displayed in the original PAGE (Figure 1A), depicted in Figure 1C as "hit", does not contain repetitive sequences and is located between two canonical Androgen Receptor Elements (AREs) (Figure 1C).
Localization (located) of Androgen Receptor
10) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.06 Pain Relevance 0
Epinephrine and Norepinephrine, typically released during stress bind to nine different adrenoceptors (AR) which classically control the cardiovascular and respiratory systems.
Localization (released) of AR in respiratory systems associated with stress
11) Confidence 0.46 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19442150 Disease Relevance 0.23 Pain Relevance 0.13
They inhibit the androgen-stimulated translocation of the AR from the cytosol to the nucleus, decrease the AR protein level in part through increased proteasomal degradation, and suppress AR transactivation activity [26,27].
Localization (translocation) of AR in nucleus
12) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.53 Pain Relevance 0.13
Because decursin and DA potently inhibit the cytosol to nuclear translocation of AR upon androgen stimulation in prostate cancer cells [26,27], we investigated whether a similar inhibitory effect was exerted on ER?.
Localization (translocation) of AR associated with reprotox - general 1
13) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.16 Pain Relevance 0
CONCLUSION: These results demonstrate RRME is a potent HAT inhibitor, which reduced AR and histone acetylation leading to decreased AR-mediated transcription and reduced LNCaP cell growth.


Localization (decreased) of AR
14) Confidence 0.43 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0 Pain Relevance 0
CONCLUSION: These results demonstrate RRME is a potent HAT inhibitor, which reduced AR and histone acetylation leading to decreased AR-mediated transcription and reduced LNCaP cell growth.


Localization (acetylation) of AR
15) Confidence 0.43 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0 Pain Relevance 0
The amino acid sequence alignments were made using sequences obtained from the GenBank sequence data bank with the following accession numbers: Human, Homo sapiens AR (M34233); Mouse, Mus musculus AR (X53779); Rat, Rattus norvegicus AR (M20133); Zebra finch, Taeniopygia guttata AR (AF532914); African clawed toad, Xenopus leavis AR (U67129); Tilapia AR?
Localization (toad) of AR in Mouse
16) Confidence 0.43 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.16 Pain Relevance 0
Furthermore, AR was cloned from stickleback kidney RNA and the molecular structures of two splicing variants, AR?
Localization (cloned) of AR in kidney
17) Confidence 0.43 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.11 Pain Relevance 0.08
The AR is implicated in ARG1 and ARG2 expression
Localization (implicated) of AR
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0 Pain Relevance 0.03
Binding of DHT to AR promotes cytosolic AR activation and the translocation of activated AR to the nucleus.
Localization (translocation) of AR in nucleus
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.37 Pain Relevance 0.04
The dissociation of AR from Heat Shock Proteins (HSP), components of the Akt signaling axis and MAPK activation were important (top 2% of sensitive interactions) irrespective of androgen status.
Localization (dissociation) of AR associated with shock
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.17 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox