INT52052

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 14.07
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHB) mitochondrion (SDHB) small molecule metabolic process (SDHB)
oxidoreductase activity (SDHB)
Anatomy Link Frequency
CSF 1
punctures 1
SDHB (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 33 99.84 Very High Very High Very High
Migraine 1 99.76 Very High Very High Very High
Cervicogenic headache 1 99.14 Very High Very High Very High
Catecholamine 17 93.64 High High
intrathecal 4 81.56 Quite High
alcohol 1 65.84 Quite High
cva 3 56.96 Quite High
imagery 5 50.40 Quite High
Analgesic 2 38.88 Quite Low
epidural 3 37.44 Quite Low
Disease Link Frequency Relevance Heat
Head Trauma 64 100.00 Very High Very High Very High
Hematoma 7 100.00 Very High Very High Very High
Headache 29 99.84 Very High Very High Very High
Lumbar Puncture Related Headaches 12 99.78 Very High Very High Very High
Intracranial Hypotension 7 99.66 Very High Very High Very High
Cancer 55 99.54 Very High Very High Very High
Post-traumatic Headache 1 99.14 Very High Very High Very High
Leukemia 6 98.60 Very High Very High Very High
Malignant Neoplastic Disease 17 98.04 Very High Very High Very High
Paraganglioma 118 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four required surgical drainage, with two developing re-accumulation of SDH.
Positive_regulation (accumulation) of SDH associated with head trauma
1) Confidence 0.68 Published 2000 Journal Bone Marrow Transplant. Section Abstract Doc Link 10713634 Disease Relevance 0.97 Pain Relevance 0.21
The first patient is an 11-year-old girl who developed a shunt-induced SDH.
Positive_regulation (induced) of SDH associated with head trauma
2) Confidence 0.67 Published 2000 Journal Pediatr Neurosurg Section Abstract Doc Link 11025421 Disease Relevance 0.46 Pain Relevance 0
The second patient, a 7-year-old boy with shunt-induced SDH, had recurrent SDH, even after shunt revision with placement of a higher-pressure valve, which resulted in prolonged lethargy.
Positive_regulation (induced) of SDH associated with head trauma
3) Confidence 0.67 Published 2000 Journal Pediatr Neurosurg Section Abstract Doc Link 11025421 Disease Relevance 0.56 Pain Relevance 0.07
It is reported silent extra-adrenal PGL of retroperitoneum is probably due to mutations of the gene for succinate dehydrogenase-B (SDHB).[5]
Positive_regulation (mutations) of SDHB
4) Confidence 0.49 Published 2010 Journal Urology Annals Section Body Doc Link PMC2934586 Disease Relevance 1.94 Pain Relevance 0.11
Several studies have shown that patients with succinate dehydrogenase subunit B (SDHB) mutations have a very high risk for developing malignant paragangliomas.
Positive_regulation (succinate) of SDHB associated with malignant neoplastic disease and paraganglioma
5) Confidence 0.49 Published 2009 Journal Pediatr. Nephrol. Section Abstract Doc Link 19189136 Disease Relevance 0.92 Pain Relevance 0.13
The authors report a case of a recurrent subdural hematoma (SDH) that was caused by a persistent cerebrospinal fluid (CSF) leak from an L1-2 fistula.
Positive_regulation (caused) of SDH in CSF associated with fistula and head trauma
6) Confidence 0.44 Published 2006 Journal Journal of neurosurgery. Spine Section Abstract Doc Link 16506488 Disease Relevance 0.79 Pain Relevance 0.09
Two of the 3 patients with paraparesis recovered after evacuation of the SDH and subdural cement; however, 1 patient with paraparesis did not recover after epidural cement leakage, despite cement evacuation.
Positive_regulation (evacuation) of SDH
7) Confidence 0.43 Published 2009 Journal J Neurosurg Spine Section Body Doc Link 19929366 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The authors present a case of a routine microdiscectomy complicated by delayed cerebrospinal leak causing a chronic SDH.
Positive_regulation (causing) of SDH
8) Confidence 0.40 Published 2009 Journal Spine J Section Body Doc Link 19643678 Disease Relevance 0.07 Pain Relevance 0
Spontaneous intracranial hypotension (SIH) is reported to cause chronic subdurai hematoma (SDH), however diagnosis of SIH in patients with SDH is not always easy.
Positive_regulation (cause) of SDH associated with intracranial hypotension and hematoma
9) Confidence 0.38 Published 2007 Journal No Shinkei Geka Section Abstract Doc Link 17695779 Disease Relevance 1.47 Pain Relevance 0.08
The tumor from this patient was negative for SDH activity.
Positive_regulation (negative) of SDH associated with cancer
10) Confidence 0.25 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1343542 Disease Relevance 0.97 Pain Relevance 0.04
Besides posttraumatic cervicogenic headache or symptomatic, secondary headache due to SDH, SAB, ICB or increased ICP, migraine- or cluster-like headache can be observed in rare cases.
Positive_regulation (increased) of SDH associated with migraine, headache and cervicogenic headache
11) Confidence 0.12 Published 1997 Journal Nervenarzt Section Abstract Doc Link 9441248 Disease Relevance 2.07 Pain Relevance 1.34
We report a high incidence of subacute, chronic and sometimes occult intracranial subdural haematoma (SDH) occurring during intensive chemotherapy for acute myeloid leukaemia (AML) with a monoblastic component.
Positive_regulation (incidence) of SDH associated with leukemia, myeloid leukemia and head trauma
12) Confidence 0.06 Published 1995 Journal Br. J. Haematol. Section Abstract Doc Link 7734350 Disease Relevance 1.11 Pain Relevance 0.03
We report a high incidence of subacute, chronic and sometimes occult intracranial subdural haematoma (SDH) occurring during intensive chemotherapy for acute myeloid leukaemia (AML) with a monoblastic component.
Positive_regulation (occurring) of SDH associated with leukemia, myeloid leukemia and head trauma
13) Confidence 0.06 Published 1995 Journal Br. J. Haematol. Section Abstract Doc Link 7734350 Disease Relevance 1.17 Pain Relevance 0.03
Lumbar punctures, known to cause exceptional SDH in nonleukaemic patients, might trigger these haemorrhagic events, eventually in combination with other predisposing factors such a haemostasis disorders or leukaemic CNS infiltration.
Neg (exceptional) Positive_regulation (cause) of SDH in punctures associated with head trauma and lumbar puncture related headaches
14) Confidence 0.05 Published 1995 Journal Br. J. Haematol. Section Abstract Doc Link 7734350 Disease Relevance 1.57 Pain Relevance 0.13

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