INT5206

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 11
Speculated 2
Reported most in Abstract
Documents 316
Total Number 318
Disease Relevance 113.83
Pain Relevance 27.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
EPI 12
testis 8
bladder 6
epithelial cells 5
SH-SY5Y 4
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2219 100.00 Very High Very High Very High
antagonist 1072 100.00 Very High Very High Very High
depression 78 100.00 Very High Very High Very High
positron emission tomography 108 99.86 Very High Very High Very High
Catecholamine 321 99.56 Very High Very High Very High
Rostral ventromedial medulla 102 99.36 Very High Very High Very High
cINOD 63 99.36 Very High Very High Very High
Potency 876 99.28 Very High Very High Very High
Central grey 186 99.20 Very High Very High Very High
Dismenorea 3 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 6053 100.00 Very High Very High Very High
Prostate Cancer 3792 100.00 Very High Very High Very High
Reprotox - General 1 1087 100.00 Very High Very High Very High
Depression 87 100.00 Very High Very High Very High
Graft Vs Host Disease 52 100.00 Very High Very High Very High
Rhinitis 40 100.00 Very High Very High Very High
Bladder Cancer 1456 99.96 Very High Very High Very High
Targeted Disruption 524 99.96 Very High Very High Very High
Carcinosarcoma 87 99.86 Very High Very High Very High
Metastasis 621 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the androgen receptor was also detected in adenomyosis, endometriosis and endometrial carcinoma.
Gene_expression (expression) of androgen receptor associated with endometriosis, dismenorea and endometrial cancer
1) Confidence 0.78 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1291578 Disease Relevance 0.54 Pain Relevance 0.15
In this background is the paradoxical observation that the growth of some AR-expressing "androgen sensitive" human prostate cancer cells can be inhibited by supraphysiologic levels of androgens.
Gene_expression (expressing) of AR associated with reprotox - general 1
2) Confidence 0.78 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.44 Pain Relevance 0.08
This response may be due to effects of high-dose androgen on inhibiting re-licensing of DNA in cells expressing high levels of AR.
Gene_expression (expressing) of AR
3) Confidence 0.78 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.41 Pain Relevance 0.07
New findings demonstrating that androgen receptor (AR) expression continues in androgen ablated patients has resulted in the classification "Castration Resistant Prostate Cancer" (CRPC) and has led to the development of new second-line "anti-ligand" hormonal agents.
Gene_expression (expression) of androgen receptor associated with reprotox - general 1
4) Confidence 0.78 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.44 Pain Relevance 0.10
This "bipolar androgen therapy" will not allow time for prostate cancer cells to adapt their AR expression in response to environmental conditions.
Gene_expression (expression) of AR associated with reprotox - general 1
5) Confidence 0.78 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.29 Pain Relevance 0
New findings demonstrating that androgen receptor (AR) expression continues in androgen ablated patients has resulted in the classification "Castration Resistant Prostate Cancer" (CRPC) and has led to the development of new second-line "anti-ligand" hormonal agents.
Gene_expression (expression) of AR associated with reprotox - general 1
6) Confidence 0.78 Published 2010 Journal Prostate Section Abstract Doc Link 20607766 Disease Relevance 0.44 Pain Relevance 0.10
Western and northern blot analyses demonstrated that FA inhibited the androgen receptor (AR) expression at mRNA and protein levels.
Gene_expression (expression) of androgen receptor
7) Confidence 0.77 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.37 Pain Relevance 0.41
FA and other similar NSAIDs may be potential candidates for chemoprevention of human prostate cancer by modulating the expression of AR.
Gene_expression (expression) of AR associated with cinod and reprotox - general 1
8) Confidence 0.77 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.35 Pain Relevance 0.32
Suppressed AR expression may be the cause of FA-mediated inhibition of the androgen inducible gene expression.
Gene_expression (expression) of AR
9) Confidence 0.77 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.36 Pain Relevance 0.40
A nonsteroidal anti-inflammatory drug, flufenamic acid, inhibits the expression of the androgen receptor in LNCaP cells.
Gene_expression (expression) of androgen receptor associated with inflammation and cinod
10) Confidence 0.77 Published 1999 Journal Endocrinology Section Title Doc Link 10537180 Disease Relevance 0.47 Pain Relevance 0.48
Western and northern blot analyses demonstrated that FA inhibited the androgen receptor (AR) expression at mRNA and protein levels.
Gene_expression (protein) of AR
11) Confidence 0.77 Published 1999 Journal Endocrinology Section Abstract Doc Link 10537180 Disease Relevance 0.37 Pain Relevance 0.41
Another mechanism could be over-expression of androgen receptor.
Gene_expression (over) of androgen receptor
12) Confidence 0.75 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.53 Pain Relevance 0.08
The AR protein can be detected even in the androgen-independent prostate cancer and AR signaling is believed to be important even in so-called "androgen independent disease".
Gene_expression (detected) of AR associated with prostate cancer and disease
13) Confidence 0.75 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.25 Pain Relevance 0.13
This raises the possibility of increasing androgen receptor expression may alter the prostate cancer cells' response to its ligand or even its antagonists.
Gene_expression (expression) of androgen receptor associated with antagonist and prostate cancer
14) Confidence 0.75 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.57 Pain Relevance 0.12
This effect was independent of the AR expression level.


Gene_expression (expression) of AR
15) Confidence 0.75 Published 2008 Journal Anticancer Res. Section Body Doc Link 18383828 Disease Relevance 0 Pain Relevance 0
The results showed that functional alpha(1A-) and alpha(1B-) adrenoceptors(AR) were expressed in human SMG, and might contribute to the regulation of saliva synthesis and secretion.
Gene_expression (expressed) of AR in saliva
16) Confidence 0.65 Published 2007 Journal Beijing Da Xue Xue Bao Section Abstract Doc Link 17304317 Disease Relevance 0 Pain Relevance 0.07
Taplin et al showed that all metastatic androgen-independent tumors examined in her study expressed high levels of androgen receptor gene transcripts, relative to the levels expressed by an androgen dependent prostate cancer cell line, LNCaP [24].
Gene_expression (expressed) of androgen receptor associated with cancer and prostate cancer
17) Confidence 0.65 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.61 Pain Relevance 0.11
The AR protein can be detected even in the androgen-independent prostate cancer and AR signaling is believed to be important even in so-called "androgen independent disease".
Gene_expression (detected) of AR associated with prostate cancer and disease
18) Confidence 0.65 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.26 Pain Relevance 0.13
The wild type androgen receptor is unresponsive or only weakly activated by antiandrogens.
Gene_expression (unresponsive) of wild type androgen receptor
19) Confidence 0.65 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.71 Pain Relevance 0.07
Moreover, there is evidence that in most carcinosarcomas, the carcinomatous and the sarcomatous components are genetically the same, as shown for 21 of 25 carcinosarcomas (84%) using the human androgen receptor (HUMARA) for detection of X-chromosome inactivation.
Gene_expression (using) of HUMARA associated with carcinosarcoma
20) Confidence 0.60 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.90 Pain Relevance 0

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