INT52061

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.50
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HSD17B6) oxidoreductase activity (HSD17B6) endoplasmic reticulum (HSD17B6)
intracellular (HSD17B6)
Anatomy Link Frequency
bile 3
liver 1
HSD17B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 14 99.52 Very High Very High Very High
cINOD 4 98.92 Very High Very High Very High
anesthesia 2 79.44 Quite High
alcohol 2 75.48 Quite High
endometriosis 1 68.52 Quite High
Dismenorea 1 66.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 98.72 Very High Very High Very High
Van Bogaert's Disease 4 96.52 Very High Very High Very High
Disease 3 94.56 High High
Dementia 2 77.36 Quite High
Inborn Error Of Metabolism 2 75.00 Quite High
Endometriosis (extended) 2 69.44 Quite High
Reprotox - General 1 1 66.68 Quite High
Epilepsy 1 65.32 Quite High
Depressive Disorder 1 64.80 Quite High
Ataxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1.
Negative_regulation (inhibitors) of hydroxysteroid
1) Confidence 0.57 Published 2009 Journal Chem. Biol. Interact. Section Title Doc Link 19007763 Disease Relevance 0.40 Pain Relevance 0.10
We have investigated the steady-state kinetics for a cytosolic 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme of human liver and its inhibition by several bile acids and anti-inflammatory drugs such as indomethacin, flufemanic acid and naproxen.
Negative_regulation (inhibition) of hydroxysteroid in bile associated with bile, inflammation and cinod
2) Confidence 0.42 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7735258 Disease Relevance 0.17 Pain Relevance 0.33
Kinetic studies of the inhibition of a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme by bile acids and anti-inflammatory drugs.
Negative_regulation (inhibition) of hydroxysteroid in liver associated with bile, inflammation and cinod
3) Confidence 0.42 Published 1995 Journal Biol. Pharm. Bull. Section Title Doc Link 7735258 Disease Relevance 0.19 Pain Relevance 0.39
Bile acid therapy is important in most of these disorders and in the case of 3 beta-hydroxysteroid delta 5-oxidoreductase/isomerase deficiency and 3-oxo-delta 4-steroid 5 beta-reductase deficiency such therapy may save the life of the affected cholestatic infant.
Negative_regulation (deficiency) of oxidoreductase in Bile associated with bile
4) Confidence 0.42 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7824882 Disease Relevance 0.42 Pain Relevance 0.21
Five inborn errors with consequences for bile acid biosynthesis have been described: 7-dehydrocholesterol 7-reductase deficiency, 3 beta-hydroxysteroid delta 5-oxidoreductase/isomerase deficiency, 3-oxo-delta 4-steroid 5 beta-reductase deficiency, sterol 27-hydroxylase deficiency (cerebrotendinous xanthomatosis), and peroxisomal disease(s) with absence of peroxisomes.
Negative_regulation (deficiency) of oxidoreductase in bile associated with bile, van bogaert's disease and disease
5) Confidence 0.42 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7824882 Disease Relevance 0.32 Pain Relevance 0.13

General Comments

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