INT52062

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Context Info
Confidence 0.37
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDK1) small molecule metabolic process (PDK1) carbohydrate metabolic process (PDK1)
Anatomy Link Frequency
liver 1
bile 1
PDK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 8 99.84 Very High Very High Very High
cINOD 6 99.24 Very High Very High Very High
alcohol 2 76.84 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.04 Very High Very High Very High
Apoptosis 13 98.56 Very High Very High Very High
Malignant Neoplastic Disease 1 81.04 Quite High
Cancer 3 67.52 Quite High
Mouth Cancer 1 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have investigated the steady-state kinetics for a cytosolic 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme of human liver and its inhibition by several bile acids and anti-inflammatory drugs such as indomethacin, flufemanic acid and naproxen.
Negative_regulation (inhibition) of dehydrogenase isozyme in bile associated with bile, inflammation and cinod
1) Confidence 0.37 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7735258 Disease Relevance 0.17 Pain Relevance 0.33
Kinetic studies of the inhibition of a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme by bile acids and anti-inflammatory drugs.
Negative_regulation (inhibition) of dehydrogenase isozyme in liver associated with bile, inflammation and cinod
2) Confidence 0.37 Published 1995 Journal Biol. Pharm. Bull. Section Title Doc Link 7735258 Disease Relevance 0.19 Pain Relevance 0.40
Apoptosis and cell cycle arrest appeared to be independent of derivative induced inhibition of PDK1 and phosphorylation of Akt and Erk1/2.
Negative_regulation (inhibition) of PDK1 associated with apoptosis
3) Confidence 0.33 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.23 Pain Relevance 0.12

General Comments

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