INT52071

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Context Info
Confidence 0.13
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
leukocyte 2
connective 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 93.48 High High
cytokine 52 90.32 High High
cINOD 4 86.96 High High
Bioavailability 1 35.60 Quite Low
corticosteroid 4 25.52 Quite Low
Kinase C 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 1 93.84 High High
INFLAMMATION 18 93.48 High High
Injury 4 92.32 High High
Infection 24 90.08 High High
Apoptosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Communicable Diseases 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, if AEBSF acts directly on the relevant protease, not just indirectly by sparing elastase inhibitor, then the relevant protease is probably a serine protease.
Negative_regulation (sparing) of Negative_regulation (inhibitor) of elastase
1) Confidence 0.13 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0 Pain Relevance 0.12
However, we saw that AEBSF added to monocytes in vitro caused an increase in the abundance of an endogenous protease inhibitor, leukocyte elastase inhibitor.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of elastase in leukocyte
2) Confidence 0.13 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.27 Pain Relevance 0.03
This oxidant is also capable of inactivating the specific inhibitor of neutrophil elastase (alpha 1-antitrypsin), thereby favouring digestion of the connective matrix. 2.
Negative_regulation (inactivating) of Negative_regulation (inhibitor) of neutrophil elastase in connective
3) Confidence 0.05 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 7736703 Disease Relevance 0.52 Pain Relevance 0.21

General Comments

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