INT52072

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Context Info
Confidence 0.31
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.37
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ces1c) endoplasmic reticulum (Ces1c)
Anatomy Link Frequency
spermatozoa 1
Ces1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 29 99.00 Very High Very High Very High
Serotonin 2 88.88 High High
agonist 2 87.36 High High
antagonist 4 84.24 Quite High
Dopamine 6 83.80 Quite High
Morphine 4 45.36 Quite Low
Spinal cord 6 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 2 98.40 Very High Very High Very High
Nephrotoxicity 7 91.48 High High
Urological Neuroanatomy 6 81.96 Quite High
Sperm Disorder 4 80.88 Quite High
Impotence 26 67.52 Quite High
Hypospadias 4 67.12 Quite High
Targeted Disruption 8 65.84 Quite High
Toxicity 10 31.04 Quite Low
Body Weight 16 5.00 Very Low Very Low Very Low
Breast Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male and female rats received APAP (1100 mg kg(-1) i.p.) alone or following pretreatment with 1-aminobenzotriazole (ABT), a suicide inhibitor of cytochromes P450, or tri-o-tolylphosphate (TOTP), an irreversible carboxyesterase inhibitor.
Negative_regulation (inhibitor) of carboxyesterase associated with paracetamol and suicidal behaviour
1) Confidence 0.31 Published 1997 Journal Toxicol. Lett. Section Abstract Doc Link 9381478 Disease Relevance 0.44 Pain Relevance 0.94
In this regard, the exposed offspring resemble males castrated as adults, which also show an early reduction of E1 erections (Leipheimer and Sachs 1993).
Negative_regulation (reduction) of E1
2) Confidence 0.21 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257594 Disease Relevance 0.26 Pain Relevance 0.19
APAP bioactivation by oxidation and deacetylation was assessed by examining the effects of 1-aminobenzotriazole (ABT), a suicide substrate inhibitor of cytochrome P450, and bis-(para-nitrophenyl) phosphate (BNPP), a reversible carboxyesterase inhibitor, on covalent binding of APAP-derived radiolabel.
Negative_regulation (inhibitor) of carboxyesterase associated with paracetamol and suicidal behaviour
3) Confidence 0.18 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 7736927 Disease Relevance 0.26 Pain Relevance 0.83
The Vz-exposed males showed a selective reduction of low-intensity (E1) erections.
Negative_regulation (reduction) of E1
4) Confidence 0.18 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257594 Disease Relevance 0.21 Pain Relevance 0.16
As expected, estrogen concentrations (E1, E2, and E1S) were significantly reduced compared with the placebo group at 12 and 24 weeks in the evaluable subjects treated with all three AIs (P < 0.001 for all comparisons; Table 4).
Negative_regulation (reduced) of E1
5) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206728 Disease Relevance 0 Pain Relevance 0
These results indicate that inhibition of HongrES1 action lead spermatozoa to become more responsive in vitro capacitation and the acrosome reaction system suggesting a possible role for this protein.
Negative_regulation (inhibition) of HongrES1 in spermatozoa
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.21 Pain Relevance 0

General Comments

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