INT52084

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Context Info
Confidence 0.71
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.99
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 1
fat 1
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 49 100.00 Very High Very High Very High
Inflammation 24 94.48 High High
alcohol 23 64.88 Quite High
addiction 2 50.88 Quite High
fibrosis 13 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 98 96.76 Very High Very High Very High
INFLAMMATION 23 94.48 High High
Hepatotoxicity 5 93.96 High High
Nash(non-alcoholic Steatohepatitis) 95 86.08 High High
Necrosis 4 83.80 Quite High
Injury 20 79.88 Quite High
Toxicity 11 75.00 Quite High
Fatty Liver 93 72.08 Quite High
Liver Disease 30 63.12 Quite High
Obesity 25 13.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pretreatment regimen resulted in hepatic changes including: centrilobular localization of 3-(cysteine-S-yl)APAP protein adducts, selective down-regulation of cytochrome P4502E1 (CYP2E1) and CYP1A2 that produced the toxic metabolite, N-acetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, and a fourfold increase in hepatocellular proliferation.
Localization (localization) of cytochrome P4502E1 associated with paracetamol and inflammation
1) Confidence 0.71 Published 1999 Journal Hepatology Section Abstract Doc Link 9918922 Disease Relevance 0.26 Pain Relevance 0.93
The pretreatment regimen resulted in hepatic changes including: centrilobular localization of 3-(cysteine-S-yl)APAP protein adducts, selective down-regulation of cytochrome P4502E1 (CYP2E1) and CYP1A2 that produced the toxic metabolite, N-acetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, and a fourfold increase in hepatocellular proliferation.
Localization (localization) of CYP2E1 associated with paracetamol and inflammation
2) Confidence 0.71 Published 1999 Journal Hepatology Section Abstract Doc Link 9918922 Disease Relevance 0.26 Pain Relevance 0.93
In contrast, livers from mice fed a HFD showed an accumulation of macro- and micro-vesicular fat at both the 8 (results not shown) and 16 week time points (Figure 1B), which was associated with increased liver triacylglycerol content (Figure 1D) and CYP2E1 protein (Figure 1E) as compared with controls.
Localization (accumulation) of CYP2E1 protein in fat
3) Confidence 0.67 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.68 Pain Relevance 0.03
One potential target for NO and O2 may be CYP2E1, which was induced by a HFD and known to be localized to the pericentral zone of the liver.
Localization (localized) of CYP2E1 in liver
4) Confidence 0.67 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.18 Pain Relevance 0.03
Furthermore, the substrates that are poorly metabolized by CYP2E1 such as fatty acids lead to uncoupling and futile catalytic cycle with increased ROS production.
Localization (metabolized) of CYP2E1
5) Confidence 0.63 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.23 Pain Relevance 0
Similar tissues from naive mice were used for immunohistochemical localization of cytochrome P4502E1 (using a polyclonal sheep anti-P4502E1 antibody).
Localization (localization) of cytochrome P4502E1
6) Confidence 0.58 Published 1995 Journal Fundam Appl Toxicol Section Abstract Doc Link 7737437 Disease Relevance 0.37 Pain Relevance 0.87

General Comments

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