INT52088

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.50
Pain Relevance 4.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 1
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 64 99.84 Very High Very High Very High
alcohol 15 98.92 Very High Very High Very High
Analgesic 5 86.24 High High
withdrawal 1 79.96 Quite High
Inflammation 32 5.00 Very Low Very Low Very Low
fibrosis 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 18 99.64 Very High Very High Very High
Injury 18 99.60 Very High Very High Very High
Necrosis 6 96.84 Very High Very High Very High
Toxicity 17 96.08 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 59 91.88 High High
Fatty Liver 126 91.80 High High
Targeted Disruption 14 76.60 Quite High
Overdose 1 72.24 Quite High
Dyslipidemia /

Combined Dyslipidemia

12 39.28 Quite Low
Hypolipidemia 2 13.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Covalent binding has recently been detected by Western blot to a 50-kDa microsomal protein that comigrated with CYP2E1 and was accompanied by a loss of the CYP2E1 activity.
CYP2E1 Binding (comigrated) of
1) Confidence 0.48 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9492391 Disease Relevance 0.18 Pain Relevance 0.51
These data are consistent with centrilobular binding of 3'-hydroxyacetanilide, mediated in part by CYP2E1, and panlobular binding, mediated by other P450 enzymes.
CYP2E1 Binding (binding) of
2) Confidence 0.37 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9492391 Disease Relevance 0.08 Pain Relevance 0.22
A significant 24-h rhythmicity was demonstrated for CYP2E1 activity, protein levels and mRNA levels.
CYP2E1 Binding (activity) of
3) Confidence 0.37 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.28 Pain Relevance 0.50
In conclusion, these findings suggest that both CYP3A and CYP2E1 contribute to APAP hepatotoxicity in alcohol-treated mice.
CYP2E1 Binding (contribute) of associated with paracetamol, hepatotoxicity and alcohol
4) Confidence 0.37 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17392391 Disease Relevance 0.38 Pain Relevance 0.76
In acetone-pretreated mice, the 150 and 400 mg/kg APAP doses caused similar depletion of CYP2E1 activity and similar levels of covalent binding of APAP to liver proteins.
CYP2E1 Binding (binding) of in liver associated with paracetamol
5) Confidence 0.37 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.17 Pain Relevance 0.94
This study was undertaken to compare the cellular distribution of bound APAP in all four major target tissues with that of cytochrome P4502E1 (a P450 isoenzyme commonly associated with APAP bioactivation), with emphasis on the cell types which later undergo necrosis.
cytochrome P4502E1 Binding (associated) of associated with necrosis and paracetamol
6) Confidence 0.35 Published 1995 Journal Fundam Appl Toxicol Section Abstract Doc Link 7737437 Disease Relevance 0.35 Pain Relevance 0.73
Microsomal oxidation of fatty acids, catalyzed by cytochrome CYP2E1, CYP4A10, CYP4A12, and CYP4A14, which are induced in mouse models of steatosis and steatohepatitis, is a potent source of ROS through uncoupling of their catalytic cycles.
CYP2E1 Binding (cytochrome) of
7) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.17 Pain Relevance 0
CYP2E1 is unique among P450s since it is loosely bound to ER membrane and naturally present in the high spin Fe+3 state.
CYP2E1 Binding (bound) of
8) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.29 Pain Relevance 0
On the 32nd day, a marginally toxic dose of APAP (360 mg/kg, ip) yielded 70% mortality in steatohepatitic mice, while all non steatohepatitic mice receiving the same dose survived. (14)C-APAP covalent binding, CYP2E1 protein, and enzyme activity did not differ from the controls, obviating increased APAP bioactivation as the cause of amplified APAP hepatotoxicity.
CYP2E1 protein Binding (binding) of associated with paracetamol and hepatotoxicity
9) Confidence 0.11 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.61 Pain Relevance 0.77

General Comments

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