INT52090

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.33
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
brain stem 2
plasma 1
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 4 99.68 Very High Very High Very High
Locus ceruleus 6 99.54 Very High Very High Very High
Clonidine 5 99.00 Very High Very High Very High
agonist 4 88.00 High High
antagonist 1 43.92 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 4 97.12 Very High Very High Very High
Urological Neuroanatomy 1 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Testosterone treatment, that activates copulatory behaviour in castrates, down regulated alpha2A-AR mRNA levels in the brainstem and 3H-clonidine binding sites densities in the cortex, where terminals of the brain stem neurones are situated.
Transcription (levels) of alpha2A-AR in brain stem associated with medulla and clonidine
1) Confidence 0.41 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965356 Disease Relevance 0.09 Pain Relevance 0.40
Indeed, the alpha 2A-AR transcript was present at mid-pregnancy, whereas high levels of alpha 2B-AR mRNA could be detected at term.
Transcription (present) of alpha 2A-AR
2) Confidence 0.32 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7738044 Disease Relevance 0 Pain Relevance 0.18
Taken together, the data indicate that administration of AS-ODN against alpha2A-ARs in the LC significantly reduced expression of alpha2A-AR mRNA in brain stem, moderately increased plasma corticosterone and had anxiolytic-like effect in the elevated plus-maze.
Transcription (expression) of alpha2A-AR in plasma associated with locus ceruleus and anxiety disorder
3) Confidence 0.11 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.15 Pain Relevance 0.19
Treatment with AS-ODN significantly reduced the levels of alpha2A-AR mRNA in the brain stem.
Transcription (levels) of alpha2A-AR in brain stem
4) Confidence 0.11 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

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