INT521

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Context Info
Confidence 0.55
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.83
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Lrtomt)
Lrtomt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 10 100.00 Very High Very High Very High
monoamine 9 100.00 Very High Very High Very High
noradrenaline 21 99.96 Very High Very High Very High
Analgesic 2 99.90 Very High Very High Very High
Morphine 14 99.62 Very High Very High Very High
Dopamine 19 99.24 Very High Very High Very High
agonist 1 98.54 Very High Very High Very High
Dorsal horn neuron 2 97.64 Very High Very High Very High
Pain 4 95.12 Very High Very High Very High
Codeine 2 84.40 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 99.84 Very High Very High Very High
Neuropathic Pain 1 96.60 Very High Very High Very High
Disease 85 96.00 Very High Very High Very High
Pain 3 95.12 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 1 93.52 High High
Sprains And Strains 4 90.24 High High
Genetic Predisposition To Disease 1 89.96 High High
Hypersensitivity 2 88.64 High High
Toxicity 4 87.36 High High
Parkinson's Disease 5 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A lethal synergism between morphine and tropolone, an inhibitor of catechol-O-methyltransferase, was previously noted in adult male Holtzman rats.
Negative_regulation (inhibitor) of catechol-O-methyltransferase associated with catechol-o-methyltransferase and morphine
1) Confidence 0.55 Published 1979 Journal Toxicology Section Abstract Doc Link 44389 Disease Relevance 0.24 Pain Relevance 0.57
The results suggest that R-Sal acts to stimulate a release of monoamines, 5-HT preferentially, with inhibition of monoamine oxidase and catechol-O-methyltransferase activities.
Negative_regulation (inhibition) of catechol-O-methyltransferase associated with catechol-o-methyltransferase and monoamine
2) Confidence 0.49 Published 1994 Journal Brain Res. Section Abstract Doc Link 8050034 Disease Relevance 0 Pain Relevance 0.55
Monoamine oxidase was inhibited and, in experiments with noradrenaline, catechol-O-methyltransferase was also inhibited.
Negative_regulation (inhibited) of catechol-O-methyltransferase associated with catechol-o-methyltransferase, noradrenaline and monoamine
3) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8935709 Disease Relevance 0 Pain Relevance 0.54
Toxic interaction between narcotic analgesics and inhibitors of catechol-O-methyltransferase.
Negative_regulation (inhibitors) of catechol-O-methyltransferase associated with catechol-o-methyltransferase and analgesic
4) Confidence 0.41 Published 1979 Journal Toxicology Section Title Doc Link 44389 Disease Relevance 0.31 Pain Relevance 0.99
In all experiments, monoamine oxidase and catechol-O-methyltransferase were inhibited by treatment with pargyline and 3',4'-dihydroxy-2-methyl-propiophenone, respectively.
Negative_regulation (inhibited) of catechol-O-methyltransferase associated with catechol-o-methyltransferase and monoamine
5) Confidence 0.34 Published 1991 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1762989 Disease Relevance 0 Pain Relevance 0.17
In all experiments, monoamine oxidase and catechol-O-methyltransferase were inhibited by treatment with pargyline and 3',4'-dihydroxy-2-methyl-propiophenone (U-0521), respectively.
Negative_regulation (inhibited) of catechol-O-methyltransferase associated with catechol-o-methyltransferase and monoamine
6) Confidence 0.34 Published 1985 Journal Blood Vessels Section Abstract Doc Link 3967097 Disease Relevance 0 Pain Relevance 0.13
A catechol-O-methyltransferase inhibitor with potent antioxidant properties, nitecapone, was used in an attempt to attenuate neuropathic symptoms.
Negative_regulation (inhibitor) of catechol-O-methyltransferase associated with catechol-o-methyltransferase and neuropathic pain
7) Confidence 0.34 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161631 Disease Relevance 0.90 Pain Relevance 0.70
Current treatment of PD is symptomatic and the primary pharmacologic therapies include dopamine replacement with levodopa, synthetic dopamine agonists, and drugs which increase dopamine supply by inhibiting its metabolism (catechol-O-methyltransferase inhibitors and monoamine oxidase B [MAO-B] inhibitors).
Negative_regulation (inhibitors) of catechol-O-methyltransferase associated with catechol-o-methyltransferase, dopamine, agonist, disease and monoamine
8) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 1.37 Pain Relevance 0.30

General Comments

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