INT52106

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Context Info
Confidence 0.52
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 57
Total Number 62
Disease Relevance 22.81
Pain Relevance 20.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 25
epithelial cells 12
Caco-2 8
monocyte 4
HCEC 4
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 1648 100.00 Very High Very High Very High
Inflammation 974 100.00 Very High Very High Very High
cytokine 413 100.00 Very High Very High Very High
chemokine 253 100.00 Very High Very High Very High
agonist 81 100.00 Very High Very High Very High
rheumatoid arthritis 37 100.00 Very High Very High Very High
Arthritis 17 100.00 Very High Very High Very High
ischemia 14 100.00 Very High Very High Very High
dexamethasone 66 99.84 Very High Very High Very High
IPN 4 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1111 100.00 Very High Very High Very High
Cancer 205 100.00 Very High Very High Very High
Stress 139 100.00 Very High Very High Very High
Rheumatoid Arthritis 47 100.00 Very High Very High Very High
Arthritis 24 100.00 Very High Very High Very High
Necrosis 22 100.00 Very High Very High Very High
Cv Unclassified Under Development 14 100.00 Very High Very High Very High
Sepsis 424 99.98 Very High Very High Very High
Adhesions 41 99.36 Very High Very High Very High
Cystic Fibrosis 28 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition was concentration-dependant, with maximal suppression of IL-8 release (5.3-fold, p < 0.001 compared to zymosan treated cells) at 8 mg/ml.


Negative_regulation (suppression) of Localization (release) of IL-8
1) Confidence 0.52 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.03
Prolastin inhibited IL-8 release by neutrophils stimulated with opsonized zymosan (Fig 3A).
Negative_regulation (inhibited) of Localization (release) of IL-8 in neutrophils
2) Confidence 0.52 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.03
The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.
Negative_regulation (reduced) of Localization (secretion) of IL-8 in HCEC associated with ischemia
3) Confidence 0.50 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.15 Pain Relevance 0.60
Our results also indicate that low concentrations of morphine (8 nM coresponding to 2.25 ng/ml) consistent with the amount of morphine found in the serum of septic patients, significantly decrease the secretion of IL-8 from human neutrophils and that this inhibition can be reversed by naloxone.
Negative_regulation (decrease) of Localization (secretion) of IL-8 in neutrophils associated with narcan and morphine
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.15 Pain Relevance 0.76
Low concentration of morphine (8 nM) significantly inhibited the release of IL-8 from neutrophils when coincubated with LPS.
Negative_regulation (inhibited) of Localization (release) of IL-8 in neutrophils associated with morphine
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808358 Disease Relevance 0.61 Pain Relevance 1.40
Costimulation of neutrophils with LPS and morphine decreased the release of IL-8 significantly (24±2 ng/106 neutrophils ±SD, n?
Negative_regulation (decreased) of Localization (release) of IL-8 in neutrophils associated with morphine
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0 Pain Relevance 1.07
opioid receptor agonist DAGO in concentrations as low as 10 nM was shown to significantly decrease the secretion of IL-8 from neutrophils after LPS stimulation [38].
Negative_regulation (decrease) of Localization (secretion) of IL-8 in neutrophils associated with agonist and opioid receptor
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.41 Pain Relevance 0.62
The present study was aimed at defining the localization of IL-8 mRNA as well as IL-8 protein at the feto-maternal interface using in situ hybridization and immunohistochemical staining.
Negative_regulation (defining) of Localization (localization) of IL-8
8) Confidence 0.43 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.10
The present study was aimed at defining the localization of IL-8 mRNA as well as IL-8 protein at the feto-maternal interface using in situ hybridization and immunohistochemical staining.
Negative_regulation (defining) of Localization (localization) of IL-8
9) Confidence 0.43 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.10
The global amount of TNF-alpha released did not vary for IPN surfaces of different moduli; however, the amount of the pro-inflammatory cytokine IL-8 released demonstrated a biphasic response, where lower (approx. 1.4 kPa) and very high (approx. 348 kPa) moduli IPN surfaces attenuated IL-8 secretion.
Negative_regulation (attenuated) of Localization (secretion) of IL-8 associated with inflammation, ipn and cytokine
10) Confidence 0.43 Published 2008 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 18854128 Disease Relevance 0.35 Pain Relevance 0.60
Furthermore, Prolastin (2.5 mg per nostril) significantly inhibited nasal IL-8 release in response to pure LPS challenge.


Negative_regulation (inhibited) of Localization (release) of IL-8 in nasal
11) Confidence 0.38 Published 2005 Journal Respir Res Section Abstract Doc Link PMC549028 Disease Relevance 0.09 Pain Relevance 0.08
We cannot determine from these experiments whether Prolastin is directly suppressing IL-8 release or suppressing another inflammatory response that leads to IL-8 release; nonetheless, our finding suggests that effects of Prolastin directed against endotoxin-stimulated inflammatory responses may be beneficial.
Spec (whether) Negative_regulation (suppressing) of Localization (release) of IL-8 associated with inflammatory response
12) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.43 Pain Relevance 0.29
In the presence of Prolastin, the LPS effect on IL-8 release was inhibited (p < 0.05) (Fig. 4).


Negative_regulation (inhibited) of Localization (release) of IL-8
13) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.39 Pain Relevance 0.08
As illustrated in figure 3B, polymeric and native AAT and Prolastin significantly inhibited the release of IL-8 protein by activated neutrophils.
Negative_regulation (inhibited) of Localization (release) of IL-8 protein in neutrophils
14) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.11 Pain Relevance 0
Concentration-dependent effects of Prolastin on neutrophil IL-8 release
Negative_regulation (neutrophil) of Localization (release) of IL-8 in neutrophil
15) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.04
Tissue trafficking of trapped CXCL8 variants
Negative_regulation (trafficking) of Localization (trapped) of CXCL8
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.09 Pain Relevance 0.04
The ischemia-induced expression of ICAM-1 in HCEC, and the expression/release of IL-8 and MCP-1 in HCEC were abolished by the non-steroid anti-inflammatory drug, indomethacin (100-300 microM).
Negative_regulation (abolished) of Localization (expression/release) of IL-8 in HCEC associated with inflammation and ischemia
17) Confidence 0.37 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.13 Pain Relevance 0.57
Inhibition of pyocyanin-potentiated IL-8 release by steroids in bronchial epithelial cells.
Negative_regulation (Inhibition) of Localization (release) of IL-8 in epithelial cells
18) Confidence 0.34 Published 2006 Journal Respir Med Section Title Doc Link 16448811 Disease Relevance 0.18 Pain Relevance 0.19
The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.
Negative_regulation (reduced) of Localization (release) of IL-8 associated with dexamethasone
19) Confidence 0.34 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.25 Pain Relevance 0.28
IL-8 release into cell-free supernatants of primary cultures of human bronchial epithelial cells, exposed to oxidative stress, was significantly inhibited by SB 203580 (Pelaia et al 2004).
Negative_regulation (inhibited) of Localization (release) of IL-8 in epithelial cells associated with stress
20) Confidence 0.33 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.78 Pain Relevance 0.13

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