INT52107

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Context Info
Confidence 0.72
First Reported 1994
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 63
Total Number 72
Disease Relevance 41.66
Pain Relevance 16.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
Caco-2 3
neutrophil 3
liver 3
leukocyte 3
joints 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1159 100.00 Very High Very High Very High
cytokine 733 100.00 Very High Very High Very High
chemokine 503 100.00 Very High Very High Very High
Osteoarthritis 121 99.84 Very High Very High Very High
Versed 7 99.00 Very High Very High Very High
ischemia 19 98.74 Very High Very High Very High
Inflammatory mediators 71 98.12 Very High Very High Very High
Arthritis 87 98.04 Very High Very High Very High
substance P 8 97.74 Very High Very High Very High
imagery 21 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1330 100.00 Very High Very High Very High
Osteoarthritis 124 99.84 Very High Very High Very High
Sprains And Strains 429 99.50 Very High Very High Very High
Neutrophil Disorders 1 99.50 Very High Very High Very High
Coronary Artery Disease 39 99.44 Very High Very High Very High
Hepatitis C Virus Infection 213 99.32 Very High Very High Very High
Otitis Media With Effusion 184 99.32 Very High Very High Very High
Chronic Hepatitis 36 99.16 Very High Very High Very High
Adenocarcinoma 101 99.04 Very High Very High Very High
Hypoxia 36 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also measured IL-8 mRNA levels in experiments performed with A549 cells, as shown in Figure 6A and B.
Transcription (levels) of IL-8 in A549
1) Confidence 0.72 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Similar to IL-8 protein levels released into the basolateral supernatants, IL-8 mRNA levels were enhanced by both ISO and BD photochemical products, although the levels did not reach statistical significance.


Transcription (levels) of IL-8
2) Confidence 0.72 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In particular, interleukin-8 (IL-8/CXCL8), which was originally described as a leukocyte chemoattractant [9], was subsequently found to possess mitogenic and angiogenic properties [10,11].
Transcription (described) of CXCL8 in leukocyte
3) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.63 Pain Relevance 0.31
In particular, interleukin-8 (IL-8/CXCL8), which was originally described as a leukocyte chemoattractant [9], was subsequently found to possess mitogenic and angiogenic properties [10,11].
Transcription (described) of interleukin-8 in leukocyte
4) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.63 Pain Relevance 0.31
In our measurements of IL8 mRNA levels in ten control participants, normalized versus EARs and versus NF, the IL8 mRNA levels with the two different approaches were similar in single human samples; also, again, the similar median value obtained (Figure 4b) confirmed the result.
Transcription (levels) of IL8
5) Confidence 0.66 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.36 Pain Relevance 0.26
In our measurements of IL8 mRNA levels in ten control participants, normalized versus EARs and versus NF, the IL8 mRNA levels with the two different approaches were similar in single human samples; also, again, the similar median value obtained (Figure 4b) confirmed the result.
Transcription (levels) of IL8
6) Confidence 0.66 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.37 Pain Relevance 0.26
The debate on the true carcinogenetic role of variant c.-352T>A probably comes from its controversial impact on IL8 transcription, sometimes described as an enhancement [51], sometimes as a downregulation [52].
Transcription (transcription) of IL8
7) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.61 Pain Relevance 0.12
It is interesting to note that in this example, group A seems to be the more appropriate control, because an increase in IL8 mRNA levels from mild (A1F1) to advanced disease (A2F3) is observed, suggesting a model with IL8 activation during fibrogenesis.


Transcription (levels) of IL8 associated with fibrosis and disease
8) Confidence 0.65 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.97 Pain Relevance 0.04
The enhancement of IL-8 and MCP-1 gene transcription and protein production was shown to be pertussis toxin sensitive attesting that this phenomenon was a Gi protein-coupled receptor-mediated process as expected for cannabinoid receptors.
Transcription (transcription) of IL-8 associated with bordatella infection and cannabinoid receptor
9) Confidence 0.64 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.10 Pain Relevance 0.67
Moreover, H. pylori induced the activation of NF-kappaB as well as AP-1, leading to IL-8 gene transcription.
Transcription (transcription) of IL-8
10) Confidence 0.63 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753246 Disease Relevance 0.78 Pain Relevance 0.09
B and activation of the transcription of various proinflammatory cytokines [13] (IL1A, IL1B, TNFA, IL6, IL8,...etc).
Transcription (transcription) of IL8 associated with cytokine
11) Confidence 0.54 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.41 Pain Relevance 0.25
Northern blot analysis also revealed increased IL-8 mRNA levels in the presence of both midazolam and propofol, which was confirmed by molecular imaging.
Transcription (levels) of IL-8 associated with versed and imagery
12) Confidence 0.53 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.14 Pain Relevance 0.32
Total RNA was isolated using Trizol (Invitrogen) following the manufacturer’s instructions and analyzed for IL-8 mRNA levels by real-time reverse transcription polymerase chain reaction (RT-PCR) as described previously (Jaspers et al. 2001).
Spec (analyzed) Transcription (levels) of IL-8
13) Confidence 0.53 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In addition, we confirmed IL-8 mRNA expression and secretion of IL-8 by an endometrial cancer cell line (Ishikawa) using the reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) methods, respectively.
Transcription (expression) of IL-8 associated with endometriosis (extended)
14) Confidence 0.53 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.08
CXCL8 mRNA expression in all seven CI joints (IOD 17,109 ± 6944) was specifically increased compared with the eight CU joints (IOD 2774 ± 1415) (P < 0.05) and the five control subjects (IOD 180 ± 66) (Figs 3 and 4).
Transcription (expression) of CXCL8 in joints
15) Confidence 0.53 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0 Pain Relevance 0.07
This notion is supported by the observation that CXCL8 mRNA expression is decreased after treatment of antigen-induced arthritis [41].
Transcription (expression) of CXCL8 associated with arthritis
16) Confidence 0.53 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.96 Pain Relevance 0.55
The increased expression of CXCL8 in CI joints compared with CU joints was confirmed by in situ hybridization to quantify CXCL8 mRNA expression.
Transcription (expression) of CXCL8 in joints
17) Confidence 0.53 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0 Pain Relevance 0.06
Our present study reveals that expression of IL-8 mRNA, a potent neutrophil chemotactic and activating peptide, is correlated with the endoscopic grade of esophagitis or with inflammatory cell infiltration.
Transcription (expression) of IL-8 in neutrophil associated with esophageal disease and inflammation
18) Confidence 0.49 Published 2007 Journal Nippon Rinsho Section Abstract Doc Link 17511218 Disease Relevance 1.24 Pain Relevance 0.43
IL8 mRNA expression increases from mild chronic hepatitis C (A1F1) to severe liver lesions (A2F3).
Transcription (expression) of IL8 in liver associated with chronic hepatitis and disease
19) Confidence 0.48 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.62 Pain Relevance 0.12
IL8 was investigated because it has been shown in culture cells that the HCV nonstructural 5A protein induces IL8.17 IL8 mRNA expression increases from mild chronic hepatitis C (A1F1) to severe liver lesions (A2F3) (Fig. 4).
Transcription (expression) of IL8 in liver associated with chronic hepatitis and hepatitis c virus infection
20) Confidence 0.48 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.97 Pain Relevance 0.05

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