INT5211

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.75
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
CD86 1
immune cells 1
microglia 1
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 98 99.56 Very High Very High Very High
Enkephalin 3 92.80 High High
Inflammation 106 72.32 Quite High
narcan 1 69.52 Quite High
cINOD 4 58.00 Quite High
fibrosis 29 56.04 Quite High
Arthritis 33 55.84 Quite High
tolerance 8 50.00 Quite Low
chemokine 19 47.40 Quite Low
Central nervous system 37 35.44 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 64 99.96 Very High Very High Very High
Cancer 5 98.88 Very High Very High Very High
Necrosis 5 98.64 Very High Very High Very High
Stress 3 76.00 Quite High
INFLAMMATION 102 72.32 Quite High
Targeted Disruption 17 71.40 Quite High
Amyloid Plaque 14 66.32 Quite High
Gliosis 2 59.76 Quite High
Pressure And Volume Under Development 9 58.32 Quite High
Fibrosis 11 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that the peptide did not influence secretion of IgM-antibody to T-independent antigen-trinitrobenzensulfoacidic group, but suppressed secretion of IgG-antibody to T-dependent antigens both during primary and secondary response.
Localization (secretion) of IgM
1) Confidence 0.78 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1292695 Disease Relevance 0 Pain Relevance 0.27
siRNA sequence (TGTTCCACTGGGCTGAGAA), specifically targeting the CD40 gene, was designed and synthesized by Dhmarcon (Dharmacon, Inc., Chicago, IL, USA).
Localization (targeting) of CD40
2) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.22 Pain Relevance 0.03
Together with Ruslan Mezhitov, he originated the concept that these phagocytic innate immune cells recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors, the most notable examples being a set of phylogenetically conserved, germ-line encoded Toll-like receptors (TLRs, currently 11–12 members, [7-10]), resulting in expression of cell-surface activation molecules [for example, major histocompatibility complex (MHC) class I and II, B7.1, B7.2, and CD40] and secretion of innate cytokines [i.e., tumor necrosis factor ?
Localization (secretion) of CD40 in immune cells associated with necrosis, cancer and cytokine
3) Confidence 0.64 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.20 Pain Relevance 0.05
secretion versus CD40L-sufficient AD mouse microglia [42].
Localization (secretion) of CD40L-sufficient in microglia associated with alzheimer's dementia
4) Confidence 0.64 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.03 Pain Relevance 0.14
They were then stained for anti-CD40, anti-CD80, anti-CD86, anti-H-2kd (all 1?
Localization (anti) of CD40 in CD86
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.07 Pain Relevance 0.08
TNF pathway group (19 transcripts): TNF, TNFSF10, TNFSF14, TNFRSF1A, TNFRSF1B, TNFRSF10B, CD27, CD40, LTBR, TNFAIP3, TRAF2, TRAF3, TRADD, TBK1, FADD, CFLAR, RIPK1, RIPK2, and MAP3K1, B.
Localization (group) of CD40
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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