INT52113

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 25.71
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CETP) transport (CETP) extracellular space (CETP)
small molecule metabolic process (CETP) extracellular region (CETP) lipid metabolic process (CETP)
Anatomy Link Frequency
plasma 5
liver 2
heart 2
blood 1
adipose tissue 1
CETP (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 61 96.44 Very High Very High Very High
Angina 39 90.92 High High
Pain 2 81.08 Quite High
headache 2 63.28 Quite High
backache 1 62.52 Quite High
abdominal pain 1 61.64 Quite High
agonist 177 20.40 Low Low
nud 2 12.12 Low Low
Inflammation 119 5.00 Very Low Very Low Very Low
alcohol 114 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 13 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 3858 99.92 Very High Very High Very High
Hyperlipoproteinemia Type Ii 27 99.90 Very High Very High Very High
Targeted Disruption 195 99.88 Very High Very High Very High
Coronary Artery Disease 162 99.72 Very High Very High Very High
Coronary Heart Disease 400 99.36 Very High Very High Very High
Cardiovascular Disease 148 96.24 Very High Very High Very High
Congenital Anomalies 24 96.12 Very High Very High Very High
Cirrhosis 17 96.04 Very High Very High Very High
Atherosclerosis 561 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, human CETP expressed in the transgenic mice plasma had no effect whatsoever on the PL transfer to mouse plasma lipoproteins or to human HDL.
Gene_expression (expressed) of CETP in plasma associated with targeted disruption and disorder of lipid metabolism
1) Confidence 0.69 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 1.00 Pain Relevance 0
CETP is synthesized in the liver, and transfers cholesteryl esters from HDL-C to LDL-C or TG-rich lipoproteins in exchange for TG.11 After addition of TG to HDL-C, HDL-C is more readily catabolized in the liver.11 Partial inhibition of CETP is associated with an increase in HDL-C of up to 100%, and may also decrease LDL-C levels.
Gene_expression (synthesized) of CETP in liver associated with disorder of lipid metabolism
2) Confidence 0.68 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.66 Pain Relevance 0.30
Two common mutants of the CETP gene produce a CETP deficiency and resultant antiatherogenic lipoprotein pattern (i.e. hyper-HDL-cholesterolemia and hypo-LDL-cholesterolemia), and the frequency of the mutant allele is more than 1 in 10 subjects in Japan.
Gene_expression (produce) of CETP gene associated with disorder of lipid metabolism
3) Confidence 0.65 Published 1995 Journal Rinsho Byori Section Abstract Doc Link 7739114 Disease Relevance 1.36 Pain Relevance 0.07
[Molecular genetics of cholesterol transport and cholesterol reverse transport disorders (familial hypercholesterolemia and CETP deficiency), and coronary heart disease].
Gene_expression (deficiency) of CETP in heart associated with coronary artery disease and hyperlipoproteinemia type ii
4) Confidence 0.57 Published 1995 Journal Rinsho Byori Section Title Doc Link 7739114 Disease Relevance 1.24 Pain Relevance 0
Found predominantly in the liver, spleen, and adipose tissue, expression of CETP is enhanced by hypercholesterolemic diets via activation of a sterol regulatory protein and through binding of oxysterols to the LXR/RXR receptor (De Grooth et al 2004).
Gene_expression (expression) of CETP in adipose tissue associated with obesity
5) Confidence 0.55 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.22 Pain Relevance 0.05
Clee et al. [28] have shown that, in double transgenic mice overexpressing LPL and CETP, HDL cholesterol levels were significantly influenced by the LPL activity while no such correlation was observed in the absence of CETP expression.
Gene_expression (overexpressing) of CETP associated with targeted disruption and disorder of lipid metabolism
6) Confidence 0.53 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 0.99 Pain Relevance 0
Clee et al. [28] have shown that, in double transgenic mice overexpressing LPL and CETP, HDL cholesterol levels were significantly influenced by the LPL activity while no such correlation was observed in the absence of CETP expression.
Gene_expression (expression) of CETP associated with targeted disruption and disorder of lipid metabolism
7) Confidence 0.53 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 0.84 Pain Relevance 0
Two common mutants of the CETP gene produce a CETP deficiency and resultant antiatherogenic lipoprotein pattern (i.e. hyper-HDL-cholesterolemia and hypo-LDL-cholesterolemia), and the frequency of the mutant allele is more than 1 in 10 subjects in Japan.
Gene_expression (produce) of CETP associated with disorder of lipid metabolism
8) Confidence 0.51 Published 1995 Journal Rinsho Byori Section Abstract Doc Link 7739114 Disease Relevance 1.36 Pain Relevance 0.07
Phase three: cholesterol ester transfer protein (CETP) mediates exchange of cholesterol esters between HDL-C and Apo B lipoproteins
Gene_expression (exchange) of CETP associated with disorder of lipid metabolism
9) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.45 Pain Relevance 0.04
The adverse outcomes of the ILLUMINATE study may have been related to off-target effects of torcetrapib, such as an increase in systolic blood pressure (limited to 1–2 mmHg) or low levels of CETP inhibition and reduced RCT (Honey 2007).
Neg (inhibition) Gene_expression (inhibition) of CETP in blood
10) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.65 Pain Relevance 0.09
Heterozygotes with a 40% decrease in CETP levels had a mean increase in HDL-C of 30% and no significant change in LDL-C levels, while homozygotes with complete loss of CETP levels had a greater than 100% increase in HDL-C and 40% decrease in LDL-C and Apo B levels (Inazu et al 1990; Koizumi et al 1991).
Gene_expression (levels) of CETP associated with disorder of lipid metabolism
11) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.09 Pain Relevance 0.04
In this study, treatment with pravastatin significantly improved lipid and angiographic parameters in patients with high baseline CETP independent of baseline lipids, suggesting plasma CETP levels may be a marker of response to statin therapy.
Gene_expression (levels) of CETP in plasma
12) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.96 Pain Relevance 0
The enzyme cholesteryl ester transfer protein (CETP) exchanges CE from HDL-C for TG in LDL-C and VLDL.
Gene_expression (exchanges) of CETP associated with disorder of lipid metabolism
13) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.35 Pain Relevance 0.04
The enzyme cholesteryl ester transfer protein (CETP) exchanges CE from HDL-C for TG in LDL-C and VLDL.
Gene_expression (exchanges) of cholesteryl ester transfer protein associated with disorder of lipid metabolism
14) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.42 Pain Relevance 0.04
Phase three: cholesterol ester transfer protein (CETP) mediates exchange of cholesterol esters between HDL-C and Apo B lipoproteins
Gene_expression (exchange) of cholesterol ester transfer protein associated with disorder of lipid metabolism
15) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.47 Pain Relevance 0.04
To check this possibility an exogenous assay was performed using human HDL (240 ug cholesterol) as PL acceptor and minimal amounts of CETP transgenic and non-transgenic mice plasma (50 ul) as sources of CETP and of PLTP.
Gene_expression (sources) of CETP in plasma associated with targeted disruption and disorder of lipid metabolism
16) Confidence 0.46 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 1.13 Pain Relevance 0
The human CETP expressed in these mice might not efficiently interact with the endogenous mice HDL.
Gene_expression (expressed) of CETP associated with disorder of lipid metabolism
17) Confidence 0.46 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 1.06 Pain Relevance 0
The plasma levels of apoB, apo CIII, Ox-LDL, CETP, hs-CRP and homocysteine were equally increased in both the VSA and CAD groups.
Gene_expression (levels) of CETP in plasma
18) Confidence 0.37 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.23 Pain Relevance 0
One-way analysis of variance (ANOVA) (SSPS for Windows version 12) was used to evaluate significant differences among groups in regards to plasma and hepatic lipids, LDL composition, hepatic enzyme activities and LCAT and CETP activities.
Gene_expression (activities) of CETP in plasma
19) Confidence 0.27 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.13 Pain Relevance 0
ACAT: acyl CoA cholesteryl acyl transferase; AT: atorvastatin; CETP: cholesterol ester transfer protein; CHD: coronary heart disease; CYP7: cholesterol 7?
Gene_expression (transfer) of CETP in heart associated with coronary artery disease
20) Confidence 0.24 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.50 Pain Relevance 0

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