INT52116

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Context Info
Confidence 0.53
First Reported 1993
Last Reported 2010
Negated 2
Speculated 8
Reported most in Abstract
Documents 20
Total Number 28
Disease Relevance 6.10
Pain Relevance 8.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 9
sensory neurons 1
muscle 1
meningeal artery 1
bladder 1
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 246 100.00 Very High Very High Very High
Neuropeptide 63 100.00 Very High Very High Very High
qutenza 24 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
Enkephalin 7 99.84 Very High Very High Very High
neuropeptide release 6 99.52 Very High Very High Very High
Peripheral nerve injury 2 98.80 Very High Very High Very High
agonist 4 98.52 Very High Very High Very High
Dorsal horn 10 98.24 Very High Very High Very High
Inflammation 40 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cystitis 15 99.96 Very High Very High Very High
Shock 162 98.88 Very High Very High Very High
Neurogenic Inflammation 6 98.52 Very High Very High Very High
Anxiety Disorder 117 98.40 Very High Very High Very High
Nervous System Injury 3 98.36 Very High Very High Very High
Natriuresis 14 97.76 Very High Very High Very High
Pressure And Volume Under Development 7 97.32 Very High Very High Very High
Pain 5 97.20 Very High Very High Very High
Heart Rate Under Development 3 96.76 Very High Very High Very High
INFLAMMATION 31 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes in PACAP immunoreactivity were observed in the L4-L5 segments.
Regulation (immunoreactivity) of PACAP
1) Confidence 0.53 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.56 Pain Relevance 0.08
This work aimed to study the effects of pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) on the mechanical and electrical activity of the circular muscle of the rat colon and the mechanisms involved in such effects.
Regulation (effects) of pituitary adenylate cyclase-activating peptide in muscle
2) Confidence 0.48 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688987 Disease Relevance 0 Pain Relevance 0.07
We examined the effect of intrathecally administered PACAP27 and PACAP38 on the rat formalin test which is considered to be a model of animal pain induced by inflammation.
Spec (examined) Regulation (effect) of PACAP38 associated with pain and inflammation
3) Confidence 0.45 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7739801 Disease Relevance 0.19 Pain Relevance 0.35
We examined the effect of intrathecally administered PACAP27 and PACAP38 on the rat formalin test which is considered to be a model of animal pain induced by inflammation.
Spec (examined) Regulation (effect) of PACAP27 associated with pain and inflammation
4) Confidence 0.45 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7739801 Disease Relevance 0.19 Pain Relevance 0.35
Effects of pituitary adenylate cyclase polypeptide (PACAP) on extinction of active avoidance learning in rats: involvement of neurotransmitters.
Regulation (Effects) of adenylate cyclase polypeptide in pituitary associated with neurotransmitter and narcan
5) Confidence 0.45 Published 2005 Journal Regul. Pept. Section Title Doc Link 15680470 Disease Relevance 0 Pain Relevance 0.36
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Regulation (Effects) of PACAP in pituitary associated with neuropeptide and hippocampus
6) Confidence 0.44 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.31
In vivo and in vitro experiments were undertaken to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on rat sympathetic preganglionic neurons (SPNs).
Regulation (effects) of pituitary adenylate cyclase activating polypeptide-38 in pituitary
7) Confidence 0.44 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067461 Disease Relevance 0 Pain Relevance 0.17
In vivo and in vitro experiments were undertaken to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on rat sympathetic preganglionic neurons (SPNs).
Regulation (effects) of pituitary adenylate cyclase activating polypeptide-38 in pituitary
8) Confidence 0.44 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067461 Disease Relevance 0 Pain Relevance 0.17
In vivo and in vitro experiments were undertaken to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on rat sympathetic preganglionic neurons (SPNs).
Regulation (effects) of PACAP-38 in pituitary
9) Confidence 0.44 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067461 Disease Relevance 0 Pain Relevance 0.17
Collectively, these data highlight the importance of the CeA in the reorganization of coping strategy in CeA-PACAP-injected animals using the shock-probe fear test to elicit fear and anxiety related responses.
Regulation (importance) of PACAP associated with anxiety disorder, shock and amygdala
10) Confidence 0.44 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.17 Pain Relevance 0.47
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Regulation (Effects) of activating polypeptide in pituitary associated with neuropeptide and hippocampus
11) Confidence 0.39 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.31
No intra-CeA PACAP injection effects were found in animals tested with the
Regulation (effects) of PACAP associated with amygdala
12) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.46 Pain Relevance 0.35
It is therefore possible that the observed pharmacologic effect of PACAP on the behaviors we have described here reflect a role for the endogenous PACAP nerve fibers in the CeA

(Koves et al. [17];

Regulation (role) of PACAP in nerve associated with amygdala
13) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.64 Pain Relevance 0.58
This study examined the effect of intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) on duodenal motility in sheep and the mechanism of the action of PACAP.
Spec (examined) Regulation (effect) of PACAP in pituitary
14) Confidence 0.38 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9809798 Disease Relevance 0 Pain Relevance 0.09
This study examined the effect of intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) on duodenal motility in sheep and the mechanism of the action of PACAP.
Spec (examined) Regulation (effect) of pituitary adenylate cyclase-activating polypeptide in pituitary
15) Confidence 0.38 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9809798 Disease Relevance 0 Pain Relevance 0.09
We examined the mechanisms of effects of vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) 27 and PACAP38 on spontaneously occurring pressure waves in ex vivo perfused rat duodenum.
Spec (examined) Regulation (effects) of pituitary adenylate cyclase activating polypeptide in duodenum
16) Confidence 0.38 Published 1999 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10354348 Disease Relevance 0 Pain Relevance 0.23
Extrinsic denervation decreased the PACAP-38 concentration in the stomach, while no change was observed in the small intestine.
Neg (no) Regulation (change) of PACAP in small intestine
17) Confidence 0.27 Published 1998 Journal Cell Tissue Res. Section Abstract Doc Link 9394044 Disease Relevance 0 Pain Relevance 0.21
No PACAP immunoreactivity was observed in the islet cells.
Neg (No) Regulation (immunoreactivity) of PACAP
18) Confidence 0.27 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 10654070 Disease Relevance 0.09 Pain Relevance 0.12
In this study the aim was to investigate the effects of isatin on thermoregulatory actions of PACAP-38, in rats.


Spec (investigate) Regulation (effects) of PACAP
19) Confidence 0.27 Published 2002 Journal BMC Neurosci Section Abstract Doc Link PMC88996 Disease Relevance 0.32 Pain Relevance 0.05
In control Wistar rats, PACAP immunoreactivity was expressed in fibers in the superficial dorsal horn at all segmental levels examined (L1, L2, and L4-S1).
Regulation (immunoreactivity) of PACAP in dorsal horn associated with dorsal horn
20) Confidence 0.27 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.41 Pain Relevance 0.05

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