INT52132

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.53
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
brain 2
globus pallidus 2
Purkinje cells 2
spinal trigeminal nucleus 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 109 100.00 Very High Very High Very High
antagonist 21 99.52 Very High Very High Very High
Opioid 5 99.44 Very High Very High Very High
anesthesia 7 99.40 Very High Very High Very High
Potency 2 99.16 Very High Very High Very High
Glutamate 105 99.08 Very High Very High Very High
tetrodotoxin 3 99.04 Very High Very High Very High
narcan 5 98.92 Very High Very High Very High
GABAergic 4 98.88 Very High Very High Very High
opioid receptor 3 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 31 90.12 High High
Absence Epilepsy 9 85.88 High High
Nociception 1 83.12 Quite High
Depression 46 81.04 Quite High
Urological Neuroanatomy 1 74.16 Quite High
Convulsion 75 61.60 Quite High
Partial Seizures 35 57.36 Quite High
Viral Meningitis 7 50.00 Quite Low
Dentatorubro-pallidoluysian Atrophy 19 5.00 Very Low Very Low Very Low
Infantile Spasms 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, these results suggest that reduction of the depolarization-evoked GABA release might contribute to thiopental anesthesia, but this seems unlikely for volatile anesthetics.
Spec (might) Positive_regulation (contribute) of Negative_regulation (reduction) of GABA associated with anesthesia and gaba
1) Confidence 0.50 Published 1995 Journal Brain Res. Section Abstract Doc Link 7743195 Disease Relevance 0 Pain Relevance 0.68
The A(2A) receptor-selective antagonist KW-6002 (3mg/kg, p.o.) caused a marked and sustained decrease of extracellular GABA levels in the globus pallidus of the 6-hydroxydopamine-lesioned rats, whereas no changes in GABA levels were observed in the globus pallidus of the non-lesioned rats.
Positive_regulation (caused) of Negative_regulation (decrease) of GABA in globus pallidus associated with gaba and antagonist
2) Confidence 0.41 Published 2000 Journal Neuroscience Section Abstract Doc Link 10996458 Disease Relevance 0 Pain Relevance 0.65
The results suggest that enhancement of GABA inhibition may increase opioid potency by inhibiting the development of acute tolerance.
Positive_regulation (enhancement) of Negative_regulation (inhibition) of GABA associated with gaba, tolerance, opioid and potency
3) Confidence 0.37 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9224789 Disease Relevance 0 Pain Relevance 0.95
At 1-2 MAC, enflurane increased GABA(A)-mediated inhibition of Purkinje cells by 97 +/- 20% to 159 +/- 38%.
Positive_regulation (increased) of Negative_regulation (inhibition) of GABA(A)-mediated in Purkinje cells associated with gaba
4) Confidence 0.34 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163374 Disease Relevance 0 Pain Relevance 0.55
An increased expression of GABA transporters in the carrageenan-injected spinal trigeminal nucleus could therefore result in a faster removal of GABA from the synaptic cleft of GABAergic axon terminals compared to normal rats.
Positive_regulation (result) of Negative_regulation (removal) of GABA in spinal trigeminal nucleus associated with gaba and gabaergic
5) Confidence 0.29 Published 2001 Journal Pain Section Abstract Doc Link 11323124 Disease Relevance 0 Pain Relevance 0.23
Furthermore, the blockade of LTP(GABA) induced by a brief in vitro ethanol treatment is mimicked by DAMGO ([D-Ala(2), N-MePhe(4), Gly-ol]-enkephalin), a MOR agonist.
Positive_regulation (induced) of Negative_regulation (blockade) of GABA associated with gaba, agonist, opioid receptor and enkephalin
6) Confidence 0.20 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20393452 Disease Relevance 0 Pain Relevance 1.28
Anesthetics enhance GABA-mediated inhibition
Positive_regulation (enhance) of Negative_regulation (inhibition) of GABA-mediated associated with gaba
7) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543467 Disease Relevance 0.08 Pain Relevance 0.42
Bumetanide, an inhibitor of the Na(+)-K(+)-2Cl- cotransporter, inhibited isoguvacine-facilitated neurokinin release, but this could be attributed to a direct inhibition of GABA(A) receptors.
Positive_regulation (attributed) of Negative_regulation (inhibition) of GABA associated with gaba
8) Confidence 0.12 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652997 Disease Relevance 0.08 Pain Relevance 0.73
Blockade of GABA-A receptors increases the concentrations of glutamate and infusion of GABA reduces the levels of glutamate after blockade of VGCC
Positive_regulation (increases) of Negative_regulation (Blockade) of GABA associated with glutamate, gaba and calcium channel
9) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0 Pain Relevance 0.70
These results suggest that elevations of GABA levels in the brain and increases in GABA-mediated inhibition may be associated with the antiseizure activity of zonisamide (Kawai et al 1994).
Positive_regulation (increases) of Negative_regulation (inhibition) of GABA-mediated in brain associated with gaba
10) Confidence 0.05 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.37 Pain Relevance 0.85

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