INT52133

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 5.35
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
bowel 4
microglia 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 11 100.00 Very High Very High Very High
dexamethasone 5 100.00 Very High Very High Very High
Inflammatory marker 19 99.84 Very High Very High Very High
Inflammatory response 163 99.80 Very High Very High Very High
Inflammation 335 99.78 Very High Very High Very High
ischemia 2 98.58 Very High Very High Very High
tetrodotoxin 7 97.52 Very High Very High Very High
Analgesic 5 93.20 High High
cytokine 61 86.72 High High
sodium channel 8 84.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 501 100.00 Very High Very High Very High
Cv General 4 Under Development 3 98.58 Very High Very High Very High
Inflammatory Bowel Disease 4 98.20 Very High Very High Very High
Injury 52 96.00 Very High Very High Very High
Pressure And Volume Under Development 1 91.16 High High
Pneumonia 28 88.16 High High
Infection 1 87.48 High High
Fever 2 81.96 Quite High
Fat Embolism 35 77.28 Quite High
Lung Injury 28 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: We have studied modulation of mucosal interleukin-6 (IL-6) secretion by T-cell activation and by anti-inflammatory agents in inflammatory bowel disease.
Regulation (modulation) of Localization (secretion) of interleukin-6 in bowel associated with inflammation
1) Confidence 0.61 Published 1994 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7973432 Disease Relevance 0.35 Pain Relevance 0.17
For the biologic response of the cells we have studied the effect of the particles on the release of IL-6 as inflammatory marker and on the intracellular synthesis of PGE2 as immune-modulating and anti-inflammatory mediator also involved in resolution of inflammation.
Regulation (effect) of Localization (release) of IL-6 associated with inflammation and inflammatory marker
2) Confidence 0.59 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.82 Pain Relevance 0.38
Aggressive fluid resuscitation following intestinal ischemia-reperfusion in immature rats prevents metabolic derangements and down regulates interleukin-6 release.
Regulation (regulates) of Localization (release) of interleukin-6 associated with cv general 4 under development and ischemia
3) Confidence 0.52 Published 1994 Journal Shock Section Title Doc Link 7743342 Disease Relevance 0.64 Pain Relevance 0.20
Inflammatory cells are responsible for the release of IL-6.
Regulation (responsible) of Localization (release) of IL-6 associated with inflammation
4) Confidence 0.45 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.71 Pain Relevance 0.15
BACKGROUND: We have studied modulation of mucosal interleukin-6 (IL-6) secretion by T-cell activation and by anti-inflammatory agents in inflammatory bowel disease.
Regulation (modulation) of Localization (secretion) of IL-6 in bowel associated with inflammation
5) Confidence 0.45 Published 1994 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7973432 Disease Relevance 0.35 Pain Relevance 0.17
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
Regulation (effect) of Localization (release) of IL-6 associated with dexamethasone
6) Confidence 0.44 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
This difference is emphasized when the relative effects of large and small particles for IL-6 release and PGE2 synthesis are opposed (Figure 3).
Regulation (effects) of Localization (release) of IL-6
7) Confidence 0.43 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.50 Pain Relevance 0.31
m Fe2O3 particles: release of IL-6 and synthesis of PGE2
Regulation (particles) of Localization (release) of IL-6
8) Confidence 0.43 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.18 Pain Relevance 0.09
For the simultaneous determination of intracellular PGE2 synthesis and IL-6 release, AM of WKY rats (0.5 × 106 cells/0.5 mL) were incubated with or without 10 ?
Regulation (determination) of Localization (release) of IL-6
9) Confidence 0.43 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0 Pain Relevance 0
Analysis of IL-6 release and intracellular PGE2 synthesis
Regulation (Analysis) of Localization (release) of IL-6
10) Confidence 0.43 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0 Pain Relevance 0
These data reveal that the suppressive effect of the small particles on IL-6 release (Figure 3A) was caused by an enhanced PGE2 synthesis (Figure 3B) compared to the large particles.


Regulation (effect) of Localization (release) of IL-6
11) Confidence 0.38 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.42 Pain Relevance 0.11
In conclusion, increased intracellular soluble iron may modulate Fe2O3 particle-induced IL-6 release and inflammatory response via PGE2 production by AM.
Spec (may) Regulation (modulate) of Localization (release) of IL-6 associated with inflammatory response
12) Confidence 0.26 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.83 Pain Relevance 0.31
Moreover, we examined the effects of paeonol on the release of inflammatory mediators such as NO, PGE(2) and IL-6.
Spec (examined) Regulation (effects) of Localization (release) of IL-6 associated with inflammatory mediators
13) Confidence 0.18 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222121 Disease Relevance 0.44 Pain Relevance 0.47
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of Localization (release) of IL-6 in microglia
14) Confidence 0.08 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.67

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