INT5214

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Context Info
Confidence 0.73
First Reported 1982
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 49
Total Number 56
Disease Relevance 13.30
Pain Relevance 44.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
spinal cord 6
salivary gland 3
striatum 2
EM-2 2
Merkel cells 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 393 100.00 Very High Very High Very High
agonist 52 100.00 Very High Very High Very High
cytokine 48 100.00 Very High Very High Very High
Dynorphin 34 100.00 Very High Very High Very High
Glutamate 29 100.00 Very High Very High Very High
gABA 23 99.92 Very High Very High Very High
narcan 72 99.84 Very High Very High Very High
Dorsal horn neuron 24 99.76 Very High Very High Very High
Neuropeptide 16 99.74 Very High Very High Very High
Spinal cord 147 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 100.00 Very High Very High Very High
Stress 20 99.96 Very High Very High Very High
Targeted Disruption 536 99.68 Very High Very High Very High
INFLAMMATION 52 98.92 Very High Very High Very High
Hyperalgesia 37 98.72 Very High Very High Very High
Nociception 318 98.54 Very High Very High Very High
Disease 16 98.48 Very High Very High Very High
Skin Diseases 4 97.76 Very High Very High Very High
Cancer 22 96.96 Very High Very High Very High
Neurodegenerative Disease 2 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are inconsistent with a negative autoregulation of endogenous enkephalin release and could suggest the involvement of the diffuse noxious inhibitory controls (DNIC).
Localization (release) of enkephalin associated with enkephalin
1) Confidence 0.73 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.16 Pain Relevance 1.22
The involvement of a presynaptic autoinhibition of endogenous enkephalin release has been suggested as a possible explanation for the paradoxical analgesia induced by low doses of naloxone.
Localization (release) of enkephalin associated with narcan, enkephalin and analgesia
2) Confidence 0.73 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.06 Pain Relevance 0.70
To the best of our knowledge, this is the first report of the ultrastructural localization of a positive met-enkephalin immunoreactivity in the dense-core granules of Merkel cells in mice.
Localization (localization) of met-enkephalin in Merkel cells associated with enkephalin
3) Confidence 0.69 Published 1991 Journal Cell Tissue Res. Section Abstract Doc Link 1786598 Disease Relevance 0 Pain Relevance 0.35
The involvement of presynaptic autoinhibition of Met-enkephalin release in naloxone-induced analgesia was studied.
Localization (release) of Met-enkephalin associated with narcan, enkephalin and analgesia
4) Confidence 0.67 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3714107 Disease Relevance 0.08 Pain Relevance 0.99
Morphine at 10(-6) to 10(-5)M depressed the high K+-evoked release of Met-enkephalin from slices of the rat brainstem by 12.5-55.9% of control, while naloxone at 10(-6)M significantly enhanced the release by 80.6%.
Localization (release) of Met-enkephalin in brainstem associated with medulla, narcan, enkephalin and morphine
5) Confidence 0.63 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3714107 Disease Relevance 0.09 Pain Relevance 1.18
Prolonged alcohol drinking can perturb aspects of this system, including a loss of control of Met-enkephalin levels at the transcriptional and translational levels, and impaired release of Met-enkephalin from tissue sources.
Localization (release) of Met-enkephalin associated with enkephalin and alcohol
6) Confidence 0.61 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.15 Pain Relevance 0.68
The electron-microscopic immunogold method was applied to Merkel cells of adult mice to demonstrate the subcellular localization of met-enkephalin-like immunoreactivity.
Localization (localization) of met-enkephalin in Merkel cells associated with enkephalin
7) Confidence 0.60 Published 1991 Journal Cell Tissue Res. Section Abstract Doc Link 1786598 Disease Relevance 0 Pain Relevance 0.30
The results appear to indicate a dual effect, analgesic or hyperalgesic, of Substance P in mice, the former probably being mediated by release of met-enkephalin.
Localization (release) of met-enkephalin associated with hyperalgesia, analgesic, enkephalin and substance p
8) Confidence 0.57 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6185874 Disease Relevance 0.45 Pain Relevance 1.50
Upon stimulation of secretion by corticotropin-releasing factor, a beta-adrenergic agonist, or barium ions, secretion of PAM activity, enkephalin convertase activity, and immunoactive hormone rose in parallel.
Localization (secretion) of enkephalin convertase associated with agonist and enkephalin
9) Confidence 0.49 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092033 Disease Relevance 0.17 Pain Relevance 0.40
Secretion of peptidyl-glycine alpha-amidating monooxygenase (PAM) activity and enkephalin convertase (a carboxypeptidase B-like enzyme) activity from AtT-20 mouse corticotrope tumor cells was compared with secretion of pro-ACTH/endorphin-derived peptides.
Localization (Secretion) of enkephalin convertase in corticotrope associated with cancer and enkephalin
10) Confidence 0.49 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092033 Disease Relevance 0.17 Pain Relevance 0.28
No measurable secretion of cytosolic, mitochondrial, or lysosomal marker enzymes was detected, indicating that the secretion of PAM activity and enkephalin convertase activity was specific and not a result of cell damage or lysis.
Localization (secretion) of enkephalin convertase associated with enkephalin
11) Confidence 0.49 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092033 Disease Relevance 0.15 Pain Relevance 0.45
During inhibition of stimulated secretion with glucocorticoids or cobalt ions, secretion of PAM activity, enkephalin convertase activity, and immunoactive hormone fell in parallel.
Localization (secretion) of enkephalin convertase associated with enkephalin
12) Confidence 0.49 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092033 Disease Relevance 0.16 Pain Relevance 0.41
Upon stimulation of secretion by corticotropin-releasing factor, a beta-adrenergic agonist, or barium ions, secretion of PAM activity, enkephalin convertase activity, and immunoactive hormone rose in parallel.
Localization (secretion) of enkephalin convertase associated with agonist and enkephalin
13) Confidence 0.43 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092033 Disease Relevance 0.17 Pain Relevance 0.40
CPE-induced contact irritation and sensitization
Localization (sensitization) of CPE
14) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1913569 Disease Relevance 0.25 Pain Relevance 0.08
CPE-induced alterations in cytokine secretion
Localization (secretion) of CPE associated with cytokine
15) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1913569 Disease Relevance 0.29 Pain Relevance 0.19
Kyotorphin is a dipeptidic neuropeptide (tyrosine-arginine) that has specific receptor coupled to G(i) and phospholipase C and elicits Met-enkephalin release.
Localization (release) of Met-enkephalin associated with neuropeptide and enkephalin
16) Confidence 0.38 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10617685 Disease Relevance 0.30 Pain Relevance 0.25
Using double labeling, in situ hybridization combined with immunocytochemistry, we demonstrated that prohormone convertase 2 (PC2) mRNA is colocalized with pro-enkephalin in the same Neuro-2a cells, suggesting that this enzyme may be responsible for processing this precursor. we also showed the presence of vasopressin mRNA and arginine-vasopressin peptide in these cells using in situ hybridization and immunocytochemistry, respectively.
Localization (colocalized) of pro-enkephalin in Neuro-2a associated with enkephalin
17) Confidence 0.35 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8674823 Disease Relevance 0.14 Pain Relevance 0.69
We have recently shown that in addition to beta-endorphin the opioid peptides Met- and Leu-enkephalin and their apparent precursors are localized in islet endocrine cells of the rat pancreas.
Localization (localized) of Leu-enkephalin in pancreas associated with enkephalin and opioid
18) Confidence 0.30 Published 1986 Journal Diabetes Section Abstract Doc Link 2944783 Disease Relevance 0.64 Pain Relevance 0.52
Our results support the existence of a turnover of delta-opioid receptors in the mouse spinal cord caused by the release of Met-enkephalin.
Localization (release) of Met-enkephalin in spinal cord associated with enkephalin, delta opioid receptors and spinal cord
19) Confidence 0.27 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9372533 Disease Relevance 0 Pain Relevance 1.01
In order to assess changes in enkephalin release and biosynthesis, the levels of the tripeptide Tyr-Gly-Gly (YGG), a characteristic extracellular metabolite of enkephalins, and of the proenkephalin mRNA in mouse striatum were evaluated after a single administration of GABAergic agents.
Localization (release) of enkephalin in striatum associated with gabaergic and enkephalin
20) Confidence 0.27 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.45

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