INT52166

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 100.00 Very High Very High Very High
addiction 8 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
butorphanol 3 99.68 Very High Very High Very High
agonist 10 96.20 Very High Very High Very High
opioid receptor 5 93.20 High High
withdrawal 3 91.44 High High
Analgesic 1 89.20 High High
Opioid 5 88.76 High High
Locus ceruleus 3 85.44 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 98.16 Very High Very High Very High
Opiate Addiction 5 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Emphasis will be placed on demonstration of a rodent model in which butorphanol administration induces dependence through a unique (in comparison with morphine) activation of the kappa-opioid receptor.
Positive_regulation (induces) of Positive_regulation (activation) of kappa-opioid receptor associated with addiction, kappa opioid receptor, butorphanol and morphine
1) Confidence 0.57 Published 1997 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 9365966 Disease Relevance 0.29 Pain Relevance 1.77
We therefore conclude that specific stimulation of the kappa-opioid receptor can activate the inwardly rectifying K+ channel through a pertussis toxin-sensitive G protein.
Positive_regulation (activate) of Positive_regulation (stimulation) of kappa-opioid receptor associated with bordatella infection and kappa opioid receptor
2) Confidence 0.19 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7746270 Disease Relevance 0.19 Pain Relevance 0.97

General Comments

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