INT52170

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.34
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cckbr) nucleus (Cckbr) cytoplasm (Cckbr)
signal transducer activity (Cckbr)
Anatomy Link Frequency
nucleus accumbens 1
sciatic nerves 1
tail 1
Cckbr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 100.00 Very High Very High Very High
Cholecystokinin 15 100.00 Very High Very High Very High
antagonist 9 100.00 Very High Very High Very High
Nucleus accumbens 3 99.98 Very High Very High Very High
agonist 4 99.96 Very High Very High Very High
gABA 7 99.00 Very High Very High Very High
antinociception 7 98.88 Very High Very High Very High
Opioid 2 97.92 Very High Very High Very High
Sciatic nerve 2 97.76 Very High Very High Very High
Pain 1 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 4 99.36 Very High Very High Very High
Gallstones 3 96.44 Very High Very High Very High
Pain 1 95.12 Very High Very High Very High
Depression 5 86.96 High High
Nociception 4 85.68 High High
Gastric Motility Disorder 1 76.36 Quite High
Gastric Fistula 1 70.20 Quite High
Gastrointestinal Disease 1 53.64 Quite High
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for a nucleus accumbens CCK2 receptor regulation of rat ventral pallidal GABA levels: a dual probe microdialysis study.
Regulation (regulation) of CCK2 in nucleus accumbens associated with nucleus accumbens and gaba
1) Confidence 0.58 Published 2000 Journal Life Sci. Section Title Doc Link 11197746 Disease Relevance 0 Pain Relevance 0.60
We have examined and compared the effect of systemic CI988, an antagonist of the cholecystokinin B receptor, and morphine on the flexor reflex in rats with intact sciatic nerves and after unilateral axotomy.
Regulation (effect) of cholecystokinin B receptor in sciatic nerves associated with antagonist, sciatic nerve, cholecystokinin and morphine
2) Confidence 0.45 Published 1994 Journal Neuroreport Section Abstract Doc Link 8199346 Disease Relevance 0.37 Pain Relevance 0.73
Our results indicate that pharmacological doses of melatonin delay gastric emptying via mechanisms that involve CCK2 and 5-HT3 receptors.
Regulation (involve) of CCK2
3) Confidence 0.45 Published 2005 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 16391413 Disease Relevance 0.20 Pain Relevance 0.07
In the present study, the effect of the CCK receptor agonist caerulein and the antagonist proglumide on antinociception induced during acute cholestasis was investigated in rats using the tail-flick test.
Regulation (effect) of CCK receptor in tail associated with antinociception, antagonist, tail-flick, agonist, gallstones and cholecystokinin
4) Confidence 0.44 Published 2002 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 11872326 Disease Relevance 0.42 Pain Relevance 1.08
We studied the effect of subcutaneous morphine and intracerebroventricularly administered cholecystokinin octapeptide sulphate ester and receptor antagonists CCK-A (MK 329) and CCK-B (L 365,260) on seizures provoked by maximal electroshock in male Sprague-Dawley rats.
Regulation (effect) of CCK-B associated with convulsion, antagonist, cholecystokinin and morphine
5) Confidence 0.25 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7746354 Disease Relevance 0.36 Pain Relevance 1.21

General Comments

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